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Differential effect of CLK SR Kinases on HIV-1 gene expression: potential novel targets for therapy

RNA processing plays a critical role in the replication of HIV-1, regulated in part through the action of host SR proteins. To explore the impact of modulating SR protein activity on virus replication, the eff...

Authors: Raymond Wong, Ahalya Balachandran, Annie YQ Mao, Wendy Dobson, Scott Gray-Owen and Alan Cochrane

Citation: Retrovirology 2011 8:47

Content type: Research Published on: 17 June 2011
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Blocking premature reverse transcription fails to rescue the HIV-1 nucleocapsid-mutant replication defect

The nucleocapsid (NC) protein of HIV-1 is critical for viral replication. Mutational analyses have demonstrated its involvement in viral assembly, genome packaging, budding, maturation, reverse transcription, ...

Authors: James A Thomas, Teresa L Shatzer and Robert J Gorelick

Citation: Retrovirology 2011 8:46

Content type: Research Published on: 17 June 2011
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Human defensins 5 and 6 enhance HIV-1 infectivity through promoting HIV attachment

Concurrent sexually transmitted infections (STIs) increase the likelihood of HIV transmission. The levels of defensins are frequently elevated in genital fluids from individuals with STIs. We have previously s...

Authors: Aprille Rapista, Jian Ding, Bernadette Benito, Yung-Tai Lo, Matthew B Neiditch, Wuyuan Lu and Theresa L Chang

Citation: Retrovirology 2011 8:45

Content type: Research Published on: 14 June 2011
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Citation: Retrovirology 2011 8(Suppl 1):A243

Content type: Meeting abstract Published on: 6 June 2011

This article is part of a Supplement: Volume 8 Supplement 1
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Murine leukemia viruses (MuLV) and Xenotropic MuLV-related viruses exhibit inter-tropic complex recombination patterns

Authors: Mattia C F Prosperi, William M Switzer, Walid Heneine and Marco Salemi

Citation: Retrovirology 2011 8(Suppl 1):A235

Content type: Meeting abstract Published on: 6 June 2011

This article is part of a Supplement: Volume 8 Supplement 1
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Multi-laboratory evaluations of XMRV nucleic acid detection assays

Authors: Graham Simmons, John M Coffin, Indira K Hewlett, Shyh-Ching Lo, Judy A Mikovits, William M Switzer, Jeffrey M Linnen, Francis Ruscetti, Simone A Glynn and Michael P Busch

Citation: Retrovirology 2011 8(Suppl 1):A231

Content type: Meeting abstract Published on: 6 June 2011

This article is part of a Supplement: Volume 8 Supplement 1
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High level of inter-species transmission of simian foamy virus from non-human primates to humans in Gabon, central Africa

Authors: Augustin Mouinga-Ondémé, Mélanie Caron, Antoine Gessain and Mirdad Kazanji

Citation: Retrovirology 2011 8(Suppl 1):A229

Content type: Meeting abstract Published on: 6 June 2011

This article is part of a Supplement: Volume 8 Supplement 1
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Structure of the xenotropic murine leukaemia virus-related virus matrix protein

Authors: Michal Doležal, Iva Pichová, Tomáš Ruml, Richard Hrabal and Michaela Rumlová

Citation: Retrovirology 2011 8(Suppl 1):A227

Content type: Meeting abstract Published on: 6 June 2011

This article is part of a Supplement: Volume 8 Supplement 1
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Cell line tropism and replication of XMRV

Authors: Krishnakumar Devadas, Mohan K H G Setty, Ragupathy Viswanath, Durga S Gaddam, Owen Wood, Shixing Tang, Jiangqin Zhao, Xue Wang, Veeraswamy Ravichandran, Sherwin Lee and Indira K Hewlett

Citation: Retrovirology 2011 8(Suppl 1):A225

Content type: Meeting abstract Published on: 6 June 2011

This article is part of a Supplement: Volume 8 Supplement 1
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The effects of XMRV gene expression on the mouse prostate

Authors: Daniel Rauch, Sirosh Bokhari, John Harding and Lee Ratner

Citation: Retrovirology 2011 8(Suppl 1):A223

Content type: Meeting abstract Published on: 6 June 2011

This article is part of a Supplement: Volume 8 Supplement 1
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XMRV replicates preferentially in mucosal sites in vivo: Relevance to XMRV transmission?

Authors: Francois Villinger, Jaydip Das Gupta, Nattawat Onlamoon, Ross Molinaro, Suganthi Suppiah, Prachi Sharma, Kenneth Rogers, Christina Gaughan, Eric Klein, Xiaoxing Qiu, Gerald Schochetman, John Hackett Jr and Robert H Silverman

Citation: Retrovirology 2011 8(Suppl 1):A219

Content type: Meeting abstract Published on: 6 June 2011

This article is part of a Supplement: Volume 8 Supplement 1
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NF-κB hyper-activation by HTLV-1 Tax induces cellular senescence, but can be alleviated by the viral anti-sense protein HBZ

Authors: Huijun Zhi, Liangpeng Yang, Yu-Liang Kuo, Yik-Khuan Ho, Hsiu-Ming Shih and Chou-Zen Giam

Citation: Retrovirology 2011 8(Suppl 1):A200

Content type: Meeting abstract Published on: 6 June 2011

This article is part of a Supplement: Volume 8 Supplement 1
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Exclusion of actin microfilaments from the cell-cell contact zone in HTLV-1 infected T-lymphocyte during the establishment of a functional virological synapse

Authors: Mohamed Nejmeddine, Isabelle Clerc, Graham P Taylor and Charles R M Bangham

Citation: Retrovirology 2011 8(Suppl 1):A199

Content type: Meeting abstract Published on: 6 June 2011

This article is part of a Supplement: Volume 8 Supplement 1
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Gene expression and glycan profiling of CD4+T cells in HAM/TSP

Authors: Daisuke Kodama, Ryuji Kubota and Shuji Izumo

Citation: Retrovirology 2011 8(Suppl 1):A197

Content type: Meeting abstract Published on: 6 June 2011

This article is part of a Supplement: Volume 8 Supplement 1
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Cumulative kinetics of epigenetic abnormalities during initiation and progression of Adult T-cell Leukemia/Lymphoma (ATLL)

Authors: Takashi Oka, Hiaki Sato, Lamia A Al-Kader, Yoko Shinnou, Kana Washio, Katsuyoshi Takata, Ichiro Murakami, Atae Utsunomiya, Mamoru Ouchida, Kiyoshi Takahashi and Tadashi Yoshino

Citation: Retrovirology 2011 8(Suppl 1):A195

Content type: Meeting abstract Published on: 6 June 2011

This article is part of a Supplement: Volume 8 Supplement 1
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The reverse genetics of HTLV-1 infected patients

Authors: Luiz C Alcantara Jr, Izabela Bialuk, Maria F de Castro-Amarante, Cody Buchmann, Sebastien Chevalier, Risaku Fukumoto, Vibeke Andresen, Cynthia Pise-Masison, Steven Jacobson, Bernardo Galvao-Castro, Antoine Gessain and Genoveffa Franchini

Citation: Retrovirology 2011 8(Suppl 1):A193

Content type: Meeting abstract Published on: 6 June 2011

This article is part of a Supplement: Volume 8 Supplement 1
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HTLV-I Tax inhibits innate antiviral signaling via NF-κB-dependent induction of SOCS1

Authors: Soratree Charoenthongtrakul, Qinjie Zhou, Noula Shembade, Nicole S Harhaj, Glen N Barber and Edward W Harhaj

Citation: Retrovirology 2011 8(Suppl 1):A191

Content type: Meeting abstract Published on: 6 June 2011

This article is part of a Supplement: Volume 8 Supplement 1
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Tax-induced rapid senescence is mediated by both classical and alternative NF-κB pathways

Authors: Yik-Khuan Ho, Huijun Zhi, Dominic DeBiaso, Hsiu-Ming Shih and Chou-Zen Giam

Citation: Retrovirology 2011 8(Suppl 1):A189

Content type: Meeting abstract Published on: 6 June 2011

This article is part of a Supplement: Volume 8 Supplement 1
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Dynamics of dendritic cells and T cells in HTLV-1-associated neuroinflammatory disease: implications in immunomodulatory therapies and diagnostic tools

Authors: Sharrón L Manuel, George Makedonas, Michael R Betts, Jay Gardner, James J Goedert, Zafar K Khan and Pooja Jain

Citation: Retrovirology 2011 8(Suppl 1):A187

Content type: Meeting abstract Published on: 6 June 2011

This article is part of a Supplement: Volume 8 Supplement 1
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Transformation of human embryonic stem cells by HTLV-1 Tax

Authors: Linda Zane, Junichiro Yasunaga, Takao Kinjo, Gustavo Brito de Melo and Kuan-Teh Jeang

Citation: Retrovirology 2011 8(Suppl 1):A164

Content type: Meeting abstract Published on: 6 June 2011

This article is part of a Supplement: Volume 8 Supplement 1
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A specificity map for HTLV-1 Tax/PDZ interactions

Authors: Karim Blibek and Jean-Claude Twizere

Citation: Retrovirology 2011 8(Suppl 1):A162

Content type: Meeting abstract Published on: 6 June 2011

This article is part of a Supplement: Volume 8 Supplement 1
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Physical and functional interaction between the HTLV-1 Tax oncoprotein and the cellular LIM domain protein FHL3

Authors: Áine McCabe, William W Hall and Noreen Sheehy

Citation: Retrovirology 2011 8(Suppl 1):A160

Content type: Meeting abstract Published on: 6 June 2011

This article is part of a Supplement: Volume 8 Supplement 1
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The human T-cell leukemia virus type I (HTLV-I) oncoprotein Tax promotes persistent NF-κB activation by blocking the phosphorylation of the adaptor molecule TAX1BP

Authors: Noula Shembade and Edward W Harhaj

Citation: Retrovirology 2011 8(Suppl 1):A158

Content type: Meeting abstract Published on: 6 June 2011

This article is part of a Supplement: Volume 8 Supplement 1
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MicroRNA expression in HTLV-1 infection and pathogenesis

Authors: Donna M D'Agostino, Katia Ruggero, Marta Biasiolo, Stefania Bortoluzzi, Cynthia A Pise-Masison, Alberto Corradin, Katia Basso, Alessandro Guffanti, Gianluca De Bellis, Giorgio Corti, Paola Zanovello, Vincenzo Bronte and Vincenzo Ciminale

Citation: Retrovirology 2011 8(Suppl 1):A156

Content type: Meeting abstract Published on: 6 June 2011

This article is part of a Supplement: Volume 8 Supplement 1
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Control of ROS production and T-cell turnover by HTLV-p13

Authors: Micol Silic-Benussi, Ilaria Cavallari, Luigi Chieco-Bianchi, Fabio di Lisa, Donna M D’Agostino, Paolo Bernardi and Vincenzo Ciminale

Citation: Retrovirology 2011 8(Suppl 1):A154

Content type: Meeting abstract Published on: 6 June 2011

This article is part of a Supplement: Volume 8 Supplement 1
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HTLV-1 Tax1 represses the proapoptotic protein Bim, which is crucial for T-cell transformation

Authors: Masaya Higuchi and Masahiro Fujii

Citation: Retrovirology 2011 8(Suppl 1):A152

Content type: Meeting abstract Published on: 6 June 2011

This article is part of a Supplement: Volume 8 Supplement 1
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Microsatellite instability in the smoldering form of adult T-cell leukemia/lymphoma (ATL) in Brazil

Authors: Marcelo Magalhães, Lourdes Farre and Achilea Bittencourt

Citation: Retrovirology 2011 8(Suppl 1):A148

Content type: Meeting abstract Published on: 6 June 2011

This article is part of a Supplement: Volume 8 Supplement 1
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Tax-mediated re-routing of the HTLV-1 p13 protein to nuclear speckles

Authors: Vibeke Andresen, Cynthia A Pise-Masison, Uma Sinha-Datta, Robyn Washington Parks, Valentina Cecchinato, Risaku Fukumoto, Christophe Nicot and Genoveffa Franchini

Citation: Retrovirology 2011 8(Suppl 1):A125

Content type: Meeting abstract Published on: 6 June 2011

This article is part of a Supplement: Volume 8 Supplement 1
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Transcriptome analysis of HTLV-1-infected cells in comparison to the normal and Tax-expressing T cells

Authors: Shruti Singh, Kevin Quann, Jordana Coelho-dos-Reis, Zafar K Khan and Pooja Jain

Citation: Retrovirology 2011 8(Suppl 1):A123

Content type: Meeting abstract Published on: 6 June 2011

This article is part of a Supplement: Volume 8 Supplement 1
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Human leukocyte antigen (HLA) class I frequencies in human T-cell lymphotropic virus type 1 (HTLV-1)-infected patients from Salvador-Brazil

Authors: Viviana N Olavarria, Maria F Grassi, Ramon Kruschewsky, Xiao-Jiang Gao, Alline Nascimento, David Watkins, Mary Carrigton and Bernardo Galvao-Castro

Citation: Retrovirology 2011 8(Suppl 1):A121

Content type: Meeting abstract Published on: 6 June 2011

This article is part of a Supplement: Volume 8 Supplement 1
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Influence of INF-gamma gene polymorphism in HTLV-1 proviral load

Authors: Rodrigo Haddad, Maurício C Rocha–Junior, Daiani C Cilião-Alves, Virgínia M D Wagatsuma, Oswaldo M Takayanagui, Eduardo A Donadi, Dimas T Covas and Simone Kashima

Citation: Retrovirology 2011 8(Suppl 1):A119

Content type: Meeting abstract Published on: 6 June 2011

This article is part of a Supplement: Volume 8 Supplement 1
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NFkB activation promotes immune activation in HTLV-I-associated myelopathy / tropical spastic paraparesis

Authors: Matthew McCormick, Unsong Oh, Dibyadeep Datta, Richard Turner, Kathryn Bobb, Dileep Monie, Drago R Sliskovic, Jie Zhang, Jeffrey Meshulam and Steven Jacobson

Citation: Retrovirology 2011 8(Suppl 1):A117

Content type: Meeting abstract Published on: 6 June 2011

This article is part of a Supplement: Volume 8 Supplement 1
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HTLV-1 affects the adipogenic differentiation of human mesenchymal stem cells

Authors: Evandra Strazza Rodrigues, Maurício C Rocha Jr, Maristela Delgado Orellana, Osvaldo Massaiti Takayanagui, Dimas Tadeu Covas and Simone Kashima

Citation: Retrovirology 2011 8(Suppl 1):A115

Content type: Meeting abstract Published on: 6 June 2011

This article is part of a Supplement: Volume 8 Supplement 1
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HTLV-2 in Central Africa: HTLV-2 subtype B strains similar to those found in Amerindian tribes are endemic in Bakola Pygmies from south Cameroon but not in surrounding Bantus and Baka Pygmies

Authors: Philippe Mauclère, Laurent Meertens, Philippe Afonso, Sabine Plancoulaine, Claudia Filippone, Edouard Betsem, Sara Calattini, Alain Froment, Monique Van Beveren, Guy de Thé, Luis Quintana-Murci, Renaud Mahieux and Antoine Gessain

Citation: Retrovirology 2011 8(Suppl 1):A82

Content type: Meeting abstract Published on: 6 June 2011

This article is part of a Supplement: Volume 8 Supplement 1
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Association between Human T-Cell Lymphotropic Virus Type 1 and 2 (HTLV 1/2) infection and tuberculosis: systematic review and meta-analysis

Authors: Sérgio Arruda, Camila Loureiro, Marcos Almeida, Dayana Mendes, Maria F R Grassi, José R Lapa, Afrânio Kritski, Kristien Verdonck, Eduardo Gotuzzo and Bernardo Galvão-Castro

Citation: Retrovirology 2011 8(Suppl 1):A80

Content type: Meeting abstract Published on: 6 June 2011

This article is part of a Supplement: Volume 8 Supplement 1
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Neurological manifestations in HTLV-1 patients with overactive bladder syndrome. A precursor of HAM/TSP?

Authors: Davi Costa, André Muniz dos Santos, Néviton Castro, Isadora Siqueira, Edgar Carvalho and Marshall Glesby

Citation: Retrovirology 2011 8(Suppl 1):A78

Content type: Meeting abstract Published on: 6 June 2011

This article is part of a Supplement: Volume 8 Supplement 1
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Genetic diversity in HTLV-1 envelope (gp46), HBZ And LTR region from assymptomatic And TSP/HAM individuals

Authors: Aline C A Mota-Miranda, Fernanda Khouri Barreto, Bernardo Galvao-Castro and Luiz C Alcantara Jr

Citation: Retrovirology 2011 8(Suppl 1):A76

Content type: Meeting abstract Published on: 6 June 2011

This article is part of a Supplement: Volume 8 Supplement 1
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HTLV-I and –II seroprevalence among United States blood donors, 2000-2009

Authors: Zhanna Kaidarova and Edward L Murphy

Citation: Retrovirology 2011 8(Suppl 1):A74

Content type: Meeting abstract Published on: 6 June 2011

This article is part of a Supplement: Volume 8 Supplement 1
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Maternal proviral load and vertical transmission of Human T cell Lymphotropic Virus type 1 in Guinea-Bissau

Authors: Carla van Tienen, Samuel J McConkey, Thushan I de Silva, Matthew Cotten, Steve Kaye, Ramu Sarge-Njie, Carlos da Costa, Nato Gonçalves, Julia Parker, Tim Vincent, Assan Jaye, Peter Aaby, Hilton Whittle and Maarten Schim van der Loeff

Citation: Retrovirology 2011 8(Suppl 1):A72

Content type: Meeting abstract Published on: 6 June 2011

This article is part of a Supplement: Volume 8 Supplement 1
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Major depression and generalized anxiety disorder among HTLV-I/II infected former blood donors

Authors: Anne M Guiltinan, Zhanna Kaidarova, Dee Behan, Cheryl Marosi, Sheila Hutching, Mandi Kaiser, Elane Moore, Deborah DeVita and Edward L Murphy

Citation: Retrovirology 2011 8(Suppl 1):A70

Content type: Meeting abstract Published on: 6 June 2011

This article is part of a Supplement: Volume 8 Supplement 1
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Phylogenetic and similarity analysis of HTLV-1 isolates from HIV-coinfected patients from the South and Southeast regions of Brazil

Authors: Mariana C Magri, Helena K Morimoto, João L P Ferreira, Rosangela Rodrigues, Luis F M Brigido and Adele Caterino-de-Araujo

Citation: Retrovirology 2011 8(Suppl 1):A68

Content type: Meeting abstract Published on: 6 June 2011

This article is part of a Supplement: Volume 8 Supplement 1
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Molecular analysis of human T-cell lymphotropic virus type 1 and 2 (HTLV-1/2) seroindeterminate blood donors from Northeast of Iran; evidence of proviral tax, env, and gag sequences

Authors: Delaram S Zanjani and Majid Shahabi

Citation: Retrovirology 2011 8(Suppl 1):A66

Content type: Meeting abstract Published on: 6 June 2011

This article is part of a Supplement: Volume 8 Supplement 1
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Influence of HTLV-1 in the clinic, microbiologic and immunologic features of tuberculosis

Authors: Maria de Lourdes S Bastos, Brooke Finkmoore, Silvane Santos, Ohana Bispo, Tasso Barreto, Ingrid Cardoso, Iana Bispo, Flávia Bastos, Lee Riley and Edgar M Carvalho

Citation: Retrovirology 2011 8(Suppl 1):A45

Content type: Meeting abstract Published on: 6 June 2011

This article is part of a Supplement: Volume 8 Supplement 1
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Three plasma biomarkers of HTLV-1-associated myelopathy/tropical spastic paraparesis

Authors: Paul Kirk, Aviva Witkover, Alan Courtney, Alexandra M Lewin, Robin Wait, Michael P Stumpf, Sylvia Richardson, Graham P Taylor and Charles R Bangham

Citation: Retrovirology 2011 8(Suppl 1):A43

Content type: Meeting abstract Published on: 6 June 2011

This article is part of a Supplement: Volume 8 Supplement 1
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Histopathologic differences between human T-lymphotropic virus type 1 (HTLV-1)-positive and HTLV-1-negative polymyositis

Authors: Hazem M Abdullah, Itsuro Higuchi, Ryuji Kubota, Eiji Matsuura, Akihiro Hashiguchi, Nashwa H Abdelbary, Yukie Inamori, Hiroshi Takashima and Shuji Izumo

Citation: Retrovirology 2011 8(Suppl 1):A39

Content type: Meeting abstract Published on: 6 June 2011

This article is part of a Supplement: Volume 8 Supplement 1
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Can we cure HTLV-I associated Adult T cell Leukemia Lymphoma?

Authors: Ali Bazarbachi, Felipe Suarez and Olivier Hermine

Citation: Retrovirology 2011 8(Suppl 1):A37

Content type: Meeting abstract Published on: 6 June 2011

This article is part of a Supplement: Volume 8 Supplement 1
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Presence of cutaneous lesion is a poor prognostic factor in patients with smoldering-type adult T-cell leukemia-lymphoma

Authors: Kentaro Yonekura, Atae Utsunomiya, Kazuhiro Kawai, Yoshifusa Takatsuka, Shogo Takeuchi, Masahito Tokunaga, Ayumu Kubota, Tamotsu Kanzaki, Youhei Uchida and Takuro Kanekura

Citation: Retrovirology 2011 8(Suppl 1):A35

Content type: Meeting abstract Published on: 6 June 2011

This article is part of a Supplement: Volume 8 Supplement 1
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Role of glycosylation in bovine leukemia virus infection

Authors: Amel-Baya Bouzar, Alix de Brogniez, Arnaud Florins, Carole François, Mathieu Boxus and Luc Willems

Citation: Retrovirology 2011 8(Suppl 1):A29

Content type: Meeting abstract Published on: 6 June 2011

This article is part of a Supplement: Volume 8 Supplement 1
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HTLV-1 propels thymic human T cell development in “human immune system” Rag2-/- IL-2R γc-/- Mice

Authors: Julien Villaudy, Melanie Wencker, Nicolas Gadot, Jean-Yves Scoazec, Louis Gazzolo, Markus G Manz and Madeleine Duc Dodon

Citation: Retrovirology 2011 8(Suppl 1):A10

Content type: Meeting abstract Published on: 6 June 2011

This article is part of a Supplement: Volume 8 Supplement 1
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Altered CD4+/CD8+ T-cell ratio in splenocytes of human T-cell leukemia virus type I Tax transgenic mice with inflammatory arthropathy

Authors: Takeo Ohsugi and Toshio Kumasaka

Citation: Retrovirology 2011 8(Suppl 1):A2

Content type: Meeting abstract Published on: 6 June 2011

This article is part of a Supplement: Volume 8 Supplement 1
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