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  • Meeting abstract
  • Open Access

Maternal proviral load and vertical transmission of Human T cell Lymphotropic Virus type 1 in Guinea-Bissau

  • 1, 2Email author,
  • 1,
  • 1, 3,
  • 1,
  • 1,
  • 1,
  • 1, 4,
  • 1, 4,
  • 1,
  • 1,
  • 1,
  • 5,
  • 1 and
  • 1, 6
Retrovirology20118 (Suppl 1) :A72

https://doi.org/10.1186/1742-4690-8-S1-A72

  • Published:

Keywords

  • Infectious Disease
  • Rural Community
  • Long Terminal Repeat
  • Identify Risk Factor
  • Vertical Transmission

Background

The relative importance of routes of transmission of Human T cell Lymphotropic Virus type 1 (HTLV-1) in Guinea-Bissau is largely unknown; vertical transmission is thought to be important, but there are very few existing data. We aimed to examine factors associated with transmission in mothers and children in Guinea-Bissau, where HTLV-1 is endemic (prevalence of 5%).

Methods

A cross-sectional survey was performed among mothers and their children (aged <15 years) in a rural community in Guinea-Bissau. A questionnaire to identify risk factors for infection and a blood sample were obtained. HTLV-1 proviral load in peripheral blood was determined and PCR was performed to compare Long Terminal Repeat (LTR) sequences in mother-child pairs.

Results

Fourteen out of 55 children (25%) of 31 HTLV-1 infected mothers were infected versus none of 70 children of 30 uninfected mothers. The only factor significantly associated with HTLV-1 infection in the child was the proviral load of the mother; the risk of infection increased significantly with the log10 proviral load in the mother's peripheral blood (OR 5.5, 95% CI 2.1-14.6, per quartile), adjusted for weaning age and maternal income. HTLV-1 sequences of the LTR region obtained from mother-child pairs were identical within pairs but differed between the pairs.

Conclusions

Vertical transmission plays an important role in HTLV-1 transmission in this community in Guinea-Bissau. The risk of transmission increases with the mother’s proviral load in the peripheral blood. Identical sequences in mother-child pairs give additional support to the maternal source of the children's infection.

Authors’ Affiliations

(1)
Viral diseases program, Medical Research Council, Fajara, Gambia
(2)
Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Centre, Rotterdam, Netherlands
(3)
Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, London, UK
(4)
Projecto de Saúde de Bandim, Bissau, Guinea-Bissau
(5)
Projecto de Saúde de Bandim/Indepth Network, Bissau, Guinea-Bissau
(6)
Municipal Health Services, Amsterdam, Netherlands

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