Articles

Humanized Mice for Infectious and Neurodegenerative disorders

Humanized mice model human disease and as such are used commonly for research studies of infectious, degenerative and cancer disorders. Recent models also reflect hematopoiesis, natural immunity, neurobiology,...

Authors: Prasanta K. Dash, Santhi Gorantla, Larisa Poluektova, Mahmudul Hasan, Emiko Waight, Chen Zhang, Milica Markovic, Benson Edagwa, Jatin Machhi, Katherine E. Olson, Xinglong Wang, R. Lee Mosley, Bhavesh Kevadiya and Howard E. Gendelman

Neutralization diversity of HIV-1 Indian subtype C envelopes obtained from cross sectional and followed up individuals against broadly neutralizing monoclonal antibodies having distinct gp120 specificities

The potential use of the broadly neutralizing monoclonal antibodies (bnAbs) towards prophylaxis and treatment to HIV-1 is currently being explored. While a number of promising bnAbs have been discovered and a ...

Authors: Ranajoy Mullick, Jyoti Sutar, Nitin Hingankar, Suprit Deshpande, Madhuri Thakar, Seema Sahay, Rajesh P. Ringe, Sampurna Mukhopadhyay, Ajit Patil, Shubhangi Bichare, Kailapuri G. Murugavel, Aylur K. Srikrishnan, Rajat Goyal, Devin Sok and Jayanta Bhattacharya

Subtype-specific differences in Gag-protease replication capacity of HIV-1 isolates from East and West Africa

The HIV-1 epidemic in sub-Saharan Africa is heterogeneous with diverse unevenly distributed subtypes and regional differences in prevalence. Subtype-specific differences in disease progression rate and transmi...

Authors: Omotayo Farinre, Kamini Gounder, Tarylee Reddy, Marcel Tongo, Jonathan Hare, Beth Chaplin, Jill Gilmour, Phyllis Kanki, Jaclyn K. Mann and Thumbi Ndung’u

Falling fowl of the chicken reference genome: pitfalls of studying polymorphic endogenous retroviruses

High quality reference genomes have facilitated the study of endogenous retroviruses (ERVs). However, there are an increasing number of published works which assume the ERVs in reference genomes are universal;...

Authors: Andrew S. Mason

A single G10T polymorphism in HIV-1 subtype C Gag-SP1 regulates sensitivity to maturation inhibitors

Maturation inhibitors (MIs) potently block HIV-1 maturation by inhibiting the cleavage of the capsid protein and spacer peptide 1 (CA-SP1). Bevirimat (BVM), a highly efficacious first-in-class MI against HIV-1...

Authors: Dibya Ghimire, Yuvraj KC, Uddhav Timilsina, Kriti Goel, T. J. Nitz, Carl T. Wild and Ritu Gaur

Elevated levels of inflammatory plasma biomarkers are associated with risk of HIV infection

To determine if individuals, from HIV-1 serodiscordant couple cohorts from Rwanda and Zambia, who become HIV-positive have a distinct inflammatory biomarker profile compared to individuals who remain HIV-negat...

Authors: Samantha McInally, Kristin Wall, Tianwei Yu, Rabindra Tirouvanziam, William Kilembe, Jill Gilmour, Susan A. Allen and Eric Hunter

Memoriam for Renaud Mahieux

Authors: Fatah Kashanchi, Ali Bazarbachi and Antoine Gessain

Extracellular vesicles from HTLV-1 infected cells modulate target cells and viral spread

The Human T-cell Lymphotropic Virus Type-1 (HTLV-1) is a blood-borne pathogen and etiological agent of Adult T-cell Leukemia/Lymphoma (ATLL) and HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis (HAM/T...

Authors: Daniel O. Pinto, Sarah Al Sharif, Gifty Mensah, Maria Cowen, Pooja Khatkar, James Erickson, Heather Branscome, Thomas Lattanze, Catherine DeMarino, Farhang Alem, Ruben Magni, Weidong Zhou, Sandrine Alais, Hélène Dutartre, Nazira El-Hage, Renaud Mahieux…

Correction to: Human T-cell leukaemia virus type 1 associated pulmonary disease: clinical and pathological features of an under-recognised complication of HTLV-1 infection

An amendment to this paper has been published and can be accessed via the original article.

Authors: Lloyd Einsiedel, Fabian Chiong, Hubertus Jersmann and Graham P. Taylor

Vpx enhances innate immune responses independently of SAMHD1 during HIV-1 infection

The genomes of HIV-2 and some SIV strains contain the accessory gene vpx, which carries out several functions during infection, including the downregulation of SAMHD1. Vpx is also commonly used in experiments to ...

Authors: Oya Cingöz, Nicolas D. Arnow, Mireia Puig Torrents and Norbert Bannert

Modulation of BRD4 in HIV epigenetic regulation: implications for finding an HIV cure

Following reverse transcription, HIV viral DNA is integrated into host cell genomes and establishes a stable latent infection, which has posed a major obstacle for obtaining a cure for HIV. HIV proviral transc...

Authors: Edrous Alamer, Chaojie Zhong, Renee Hajnik, Lynn Soong and Haitao Hu

Seroprevalence of human T-lymphotropic virus infection among blood donors in China: a first nationwide survey

So far, the prevalence of human T-lymphotropic virus (HTLV) type 1 and 2 in some highly populated countries such as China is still unknown. In this study, a multi-center nationwide serological survey was desig...

Authors: Le Chang, Shanhai Ou, Zhengang Shan, Faming Zhu, Huimin Ji, Xia Rong, Fei Guo, Xinyi Jiang, Huizhen Sun, Ying Yan and Lunan Wang

Human T-cell leukaemia virus type 1 associated pulmonary disease: clinical and pathological features of an under-recognised complication of HTLV-1 infection

The lung is one of several organs that can be affected by HTLV-1 mediated inflammation. Pulmonary inflammation associated with HTLV-1 infection involves the interstitium, airways and alveoli, resulting in seve...

Authors: Lloyd Einsiedel, Fabian Chiong, Hubertus Jersmann and Graham P. Taylor

Inconsistent reversal of HIV-1 latency ex vivo by antigens of HIV-1, CMV, and other infectious agents

A reservoir of replication-competent but latent virus is the main obstacle to a cure for HIV-1 infection. Much of this reservoir resides in memory CD4 T cells. We hypothesized that these cells can be reactivat...

Authors: Thomas Vollbrecht, Aaron O. Angerstein, Bryson Menke, Nikesh M. Kumar, Michelli Faria de Oliveira, Douglas D. Richman and John C. Guatelli

Comparative analysis of human microglial models for studies of HIV replication and pathogenesis

HIV associated neurocognitive disorders cause significant morbidity and mortality despite the advent of highly active antiretroviral therapy. A deeper understanding of fundamental mechanisms underlying HIV inf...

Authors: Mohammad A. Rai, Jason Hammonds, Mario Pujato, Christopher Mayhew, Krishna Roskin and Paul Spearman

Koala retrovirus diversity, transmissibility, and disease associations

Koalas are infected with the koala retrovirus (KoRV) that exists as exogenous or endogenous viruses. KoRV is genetically diverse with co-infection with up to ten envelope subtypes (A-J) possible; KoRV-A is the...

Authors: HaoQiang Zheng, Yi Pan, Shaohua Tang, Geoffrey W. Pye, Cynthia K. Stadler, Larry Vogelnest, Kimberly Vinette Herrin, Bruce A. Rideout and William M. Switzer

Increased HIV-1 pretreatment drug resistance with consistent clade homogeneity among ART-naive HIV-1 infected individuals in Ethiopia

The development of pretreatment drug resistance (PDR) is becoming an obstacle to the success of antiretroviral therapy (ART). Besides, data from developing settings including Ethiopia is still limited. Therefo...

Authors: Mulugeta Kiros, Dawit Hailu Alemayehu, Eleni Geberekidan, Adane Mihret, Melanie Maier, Woldaregay Erku Abegaz and Andargachew Mulu

HIV and the tuberculosis “set point”: how HIV impairs alveolar macrophage responses to tuberculosis and sets the stage for progressive disease

As HIV has fueled a global resurgence of tuberculosis over the last several decades, there is a growing awareness that HIV-mediated impairments in both innate and adaptive immunity contribute to the heightened...

Authors: Sara C. Auld and Bashar S. Staitieh

Alpha-enolase in viral target cells suppresses the human immunodeficiency virus type 1 integration

A protein exhibiting more than one biochemical function is termed a moonlighting protein. Glycolytic enzymes are typical moonlighting proteins, and these enzymes control the infection of various viruses. Previ...

Authors: Naoki Kishimoto, Kengo Yamamoto, Nozomi Iga, Chie Kirihara, Towa Abe, Nobutoki Takamune and Shogo Misumi

A novel positive feedback-loop between the HTLV-1 oncoprotein Tax and NF-κB activity in T-cells

Human T-cell leukemia virus type 1 (HTLV-1) infects primarily CD4⁺ T-lymphocytes and evoques severe diseases, predominantly Adult T-Cell Leukemia/ Lymphoma (ATL/L) and HTLV-1-associated Myelopathy/ Tropical Spast...

Authors: Sebastian Millen, Lina Meretuk, Tim Göttlicher, Sarah Schmitt, Bernhard Fleckenstein and Andrea K. Thoma-Kress

HLA-B*35 as a new marker for susceptibility to human T-cell lymphotropic virus type 1 (HTLV-1) Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) in patients living in Argentina

Human T-cell lymphotropic virus type 1 (HTLV-1) is the etiological agent of HTLV associated myelopathy/ Tropical Spastic Paraparesis (HAM/TSP) and Adult T cell leukemia/lymphoma (ATLL), in around 2–5% of the i...

Authors: Paula Benencio, Sindy A. Fraile Gonzalez, Nicolás Ducasa, Kimberly Page, Carolina A. Berini and Mirna M. Biglione

Influence of the amino-terminal sequence on the structure and function of HIV integrase

Antiretroviral therapy (ART) can mitigate the morbidity and mortality caused by the human immunodeficiency virus (HIV). Successful development of ART can be accelerated by accurate structural and biochemical d...

Authors: Grant Eilers, Kushol Gupta, Audrey Allen, Jeffrey Zhou, Young Hwang, Michael B. Cory, Frederic D. Bushman and Gregory Van Duyne

Interferon regulatory factor 4 as a therapeutic target in adult T-cell leukemia lymphoma

Adult T-cell leukemia lymphoma (ATLL) is a chemotherapy-resistant malignancy with a median survival of less than one year that will afflict between one hundred thousand and one million individuals worldwide wh...

Authors: Daniel A. Rauch, Sydney L. Olson, John C. Harding, Hemalatha Sundaramoorthi, Youngsoo Kim, Tianyuan Zhou, A. Robert MacLeod, Grant Challen and Lee Ratner

Establishment of a novel diagnostic test algorithm for human T-cell leukemia virus type 1 infection with line immunoassay replacement of western blotting: a collaborative study for performance evaluation of diagnostic assays in Japan

The reliable diagnosis of human T-cell leukemia virus type 1 (HTLV-1) infection is important, particularly as it can be vertically transmitted by breast feeding mothers to their infants. However, current diagn...

Authors: Kazu Okuma, Madoka Kuramitsu, Toshihiro Niwa, Tomokuni Taniguchi, Yumiko Masaki, Gohzoh Ueda, Chieko Matsumoto, Rieko Sobata, Yasuko Sagara, Hitomi Nakamura, Masahiro Satake, Kiyonori Miura, Naoki Fuchi, Hideaki Masuzaki, Akihiko Okayama, Kazumi Umeki…

Dynamic nanopore long-read sequencing analysis of HIV-1 splicing events during the early steps of infection

Alternative splicing is a key step in Human Immunodeficiency Virus type 1 (HIV-1) replication that is tightly regulated both temporally and spatially. More than 50 different transcripts can be generated from a...

Authors: Nam Nguyen Quang, Sophie Goudey, Emmanuel Ségéral, Ammara Mohammad, Sophie Lemoine, Corinne Blugeon, Margaux Versapuech, Jean-Christophe Paillart, Clarisse Berlioz-Torrent, Stéphane Emiliani and Sarah Gallois-Montbrun

Longitudinal analysis of subtype C envelope tropism for memory CD4⁺ T cell subsets over the first 3 years of untreated HIV-1 infection

HIV-1 infects a wide range of CD4⁺ T cells with different phenotypic properties and differing expression levels of entry coreceptors. We sought to determine the viral tropism of subtype C (C-HIV) Envelope (Env) c...

Authors: Matthew J. Gartner, Paul R. Gorry, Carolin Tumpach, Jingling Zhou, Ashanti Dantanarayana, J. Judy Chang, Thomas A. Angelovich, Paula Ellenberg, Annemarie E. Laumaea, Molati Nonyane, Penny L. Moore, Sharon R. Lewin, Melissa J. Churchill, Jacqueline K. Flynn and Michael Roche

Correction to: HIV-1 IN/Pol recruits LEDGF/p75 into viral particles

An amendment to this paper has been published and can be accessed via the original article.

Authors: Belete Ayele Desimmie, Caroline Weydert, Rik Schrijvers, Sofie Vets, Jonas Demeulemeester, Paul Proost, Igor Paron, Jan De Rijck, Jan Mast, Norbert Bannert, Rik Gijsbers, Frauke Christ and Zeger Debyser

Correction to: LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions

An amendment to this paper has been published and can be accessed via the original article.

Authors: Belete Ayele Desimmie, Rik Schrijvers, Jonas Demeulemeester, Doortje Borrenberghs, Caroline Weydert, Wannes Thys, Sofie Vets, Barbara Van Remoortel, Johan Hofkens, Jan De Rijck, Jelle Hendrix, Norbert Bannert, Rik Gijsbers, Frauke Christ and Zeger Debyser

The KT Jeang Retrovirology prize 2020: Tatyana Golovkina

Authors:

M-Sec facilitates intercellular transmission of HIV-1 through multiple mechanisms

HIV-1 promotes the formation of tunneling nanotubes (TNTs) that connect distant cells, aiding cell-to-cell viral transmission between macrophages. Our recent study suggests that the cellular protein M-Sec play...

Authors: Sameh Lotfi, Hesham Nasser, Osamu Noyori, Masateru Hiyoshi, Hiroaki Takeuchi, Yoshio Koyanagi and Shinya Suzu

Variations in Trim5α and Cyclophilin A genes among HIV-1 elite controllers and non controllers in Uganda: a laboratory-based cross-sectional study

Tripartite Motif Containing 5 alpha (TRIM5α), a restriction factor produced ubiquitously in cells and tissues of the body plays an important role in the immune response against HIV. TRIM5α targets the HIV caps...

Authors: Sharon Bright Amanya, Brian Nyiro, Francis Waswa, Bonniface Obura, Rebecca Nakaziba, Eva Nabulime, Ashaba Fred Katabazi, Rose Nabatanzi, Alice Bayiyana, Gerald Mboowa, Alex Kayongo, Misaki Wayengera and Obondo J. Sande

Increased expression of CDKN1A/p21 in HIV-1 controllers is correlated with upregulation of ZC3H12A/MCPIP1

Some multifunctional cellular proteins, as the monocyte chemotactic protein-induced protein 1 (ZC3H12A/MCPIP1) and the cyclin-dependent kinase inhibitor CDKN1A/p21, are able to modulate the cellular susceptibi...

Authors: Suwellen S. D. de Azevedo, Marcelo Ribeiro-Alves, Fernanda H. Côrtes, Edson Delatorre, Lucia Spangenberg, Hugo Naya, Leonardo N. Seito, Brenda Hoagland, Beatriz Grinsztejn, Valdilea G. Veloso, Mariza G. Morgado, Thiago Moreno L. Souza and Gonzalo Bello

HIV-1 subtype C transmitted founders modulate dendritic cell inflammatory responses

Heterosexual transmission remains the main route of HIV-1 transmission and female genital tract (FGT) inflammation increases the risk of infection. However, the mechanism(s) by which inflammation facilitates i...

Authors: Evelyn Ngwa Lumngwena, Simon Metenou, Lindi Masson, Claudia Cicala, James Arthos and Zenda Woodman

MxB impedes the NUP358-mediated HIV-1 pre-integration complex nuclear import and viral replication cooperatively with CPSF6

The human myxovirus resistance 2 (Mx2/MxB) protein was originally found to regulate cytoplasmic-nuclear transport but was recently reported to restrict HIV-1 replication by binding to HIV-1 capsid (CA), preven...

Authors: Linlin Xie, Lang Chen, Chaojie Zhong, Ting Yu, Zhao Ju, Meirong Wang, Hairong Xiong, Yan Zeng, Jianhua Wang, Haitao Hu, Wei Hou and Yong Feng

Frequent horizontal and mother-to-child transmission may contribute to high prevalence of STLV-1 infection in Japanese macaques

Simian T-cell leukemia virus type 1 (STLV-1) is disseminated among various non-human primate species and is closely related to human T-cell leukemia virus type 1 (HTLV-1), the causative agent of adult T-cell l...

Authors: Megumi Murata, Jun-ichirou Yasunaga, Ayaka Washizaki, Yohei Seki, Madoka Kuramitsu, Wei Keat Tan, Anna Hu, Kazu Okuma, Isao Hamaguchi, Takuo Mizukami, Masao Matsuoka and Hirofumi Akari

Comparison of pathological clotting using haematological, functional and morphological investigations in HIV-positive and HIV-negative patients with deep vein thrombosis

Patients infected with the human immunodeficiency virus (HIV) are more prone to systemic inflammation and pathological clotting, and many may develop deep vein thrombosis (DVT) as a result of this dysregulated...

Authors: Brandon S. Jackson, Julien Nunes Goncalves and Etheresia Pretorius

Non-active site mutants of HIV-1 protease influence resistance and sensitisation towards protease inhibitors

HIV-1 can develop resistance to antiretroviral drugs, mainly through mutations within the target regions of the drugs. In HIV-1 protease, a majority of resistance-associated mutations that develop in response ...

Authors: Tomas Bastys, Vytautas Gapsys, Hauke Walter, Eva Heger, Nadezhda T. Doncheva, Rolf Kaiser, Bert L. de Groot and Olga V. Kalinina

Generation and validation of a highly sensitive bioluminescent HIV-1 reporter vector that simplifies measurement of virus release

The continued persistence of HIV-1 as a public health concern due to the lack of a cure calls for the development of new tools for studying replication of the virus. Here, we used NanoLuc, a small and extremel...

Authors: James Kirui and Eric O. Freed

Functional properties and sequence variation of HTLV-1 p13

Human T cell leukemia virus type-1 (HTLV-1) was the first retrovirus found to cause cancer in humans, but the mechanisms that drive the development of leukemia and other diseases associated with HTLV-1 infecti...

Authors: Maria Omsland, Micol Silic-Benussi, Ramona Moles, Sarkis Sarkis, Damian F. J. Purcell, David Yurick, Georges Khoury, Donna M. D’Agostino, Vincenzo Ciminale and Genoveffa Franchini

Identification of the distribution of human endogenous retroviruses K (HML-2) by PCR-based target enrichment sequencing

Human endogenous retroviruses (HERVs), suspected to be transposition-defective, may reshape the transcriptional network of the human genome by regulatory elements distributed in their long terminal repeats (LT...

Authors: Bei Xue, Tiansheng Zeng, Lisha Jia, Dongsheng Yang, Stanley L. Lin, Leonardo A. Sechi and David J. Kelvin

The three lives of Pierre Boulanger

Authors: Nathalie Chazal, Hugues de Rocquigny, Philippe Roussel, Serge Bouaziz, Françoise Barré-Sinoussi, Jean-François Delfraissy and Jean-Luc Darlix

Moving beyond the mousetrap: current and emerging humanized mouse and rat models for investigating prevention and cure strategies against HIV infection and associated pathologies

The development of safe and effective combination antiretroviral therapies for human immunodeficiency virus (HIV) infection over the past several decades has significantly reduced HIV-associated morbidity and ...

Authors: Yash Agarwal, Cole Beatty, Shivkumar Biradar, Isabella Castronova, Sara Ho, Kevin Melody and Moses Turkle Bility

Benefits and limitations of humanized mice in HIV persistence studies

Significant advances in the treatment of HIV infection have been made in the last three decades. Antiretroviral therapy (ART) is now potent enough to prevent virus replication and stop disease progression. How...

Authors: Matthew D. Marsden

DDX5 potentiates HIV-1 transcription as a co-factor of Tat

HIV-1 does not encode a helicase and hijacks those of the cell for efficient replication. We and others previously showed that the DEAD box helicase, DDX5, is an essential HIV dependency factor. DDX5 was recen...

Authors: Nyaradzai Sithole, Claire A. Williams, Truus E. M. Abbink and Andrew M. L. Lever

Arsenic trioxide (As₂O₃) as a maintenance therapy for adult T cell leukemia/lymphoma

Adult T-cell leukemia-lymphoma (ATL) is an aggressive mature lymphoid proliferation associated with poor prognosis. Standard of care includes chemotherapy and/or the combination of zidovudine and interferon-al...

Authors: Ambroise Marçais, Lucy Cook, Aviva Witkover, Vahid Asnafi, Véronique Avettand-Fenoel, Richard Delarue, Morgane Cheminant, David Sibon, Laurent Frenzel, Hugues de Thé, Charles R. M. Bangham, Ali Bazarbachi, Olivier Hermine and Felipe Suarez

The challenge of describing the epidemiology of HTLV in the Amazon region of Brazil

HTLV-1 was the first described human retrovirus and was soon found to be associated with severe clinical diseases, including a devastating lymphoma/leukemia and other inflammatory diseases. Although HTLV-2 is ...

Authors: Ricardo Ishak, Marluísa de Oliveira Guimarães Ishak and Antonio Carlos R. Vallinoto

The KT Jeang Retrovirology Prize 2020: call for nominations

Authors: Susan R. Ross, Johnson Mak and Ariberto Fassati

Longitudinal within-host evolution of HIV Nef-mediated CD4, HLA and SERINC5 downregulation activity: a case study

The HIV accessory protein Nef downregulates the viral entry receptor CD4, the Human Leukocyte Antigen (HLA)-A and -B molecules, the Serine incorporator 5 (SERINC5) protein and other molecules from the infected...

Authors: Hanwei Sudderuddin, Natalie N. Kinloch, Steven W. Jin, Rachel L. Miller, Bradley R. Jones, Chanson J. Brumme, Jeffrey B. Joy, Mark A. Brockman and Zabrina L. Brumme

HTLV-1 bZIP factor: the key viral gene for pathogenesis

Human T cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia-lymphoma (ATL) and inflammatory diseases. The HTLV-1 bZIP factor (HBZ) gene is constantly expressed in HTLV-1 infected cells and ATL cel...

Authors: Masao Matsuoka and Jean-Michel Mesnard

An insight to HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) pathogenesis; evidence from high-throughput data integration and meta-analysis

Human T-lymphotropic virus 1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a progressive disease of the central nervous system that significantly affected spinal cord, nevertheless, the patho...

Authors: Sayed-Hamidreza Mozhgani, Mehran Piran, Mohadeseh Zarei-Ghobadi, Mohieddin Jafari, Seyed-Mohammad Jazayeri, Talat Mokhtari-Azad, Majid Teymoori-Rad, Narges Valizadeh, Hamid Farajifard, Mehdi Mirzaie, Azam Khamseh, Houshang Rafatpanah, Seyed-Abdolrahim Rezaee and Mehdi Norouzi