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Research
Insertion of retroviral genome DNA occurs in the chromatin of the host cell. This step is modulated by chromatin structure as nucleosomes compaction was shown to prevent HIV-1 integration and chromatin remodel...
Retrovirology 2017 14:39
Published on: 28 July 2017
Obituary
Retrovirology 2017 14:38
Published on: 28 June 2017
Editorial
Retrovirology 2017 14:37
Published on: 21 June 2017
Review
Integrase strand transfer inhibitors (INSTIs) are the newest class of antiretroviral drugs to be approved for treatment and act by inhibiting the essential HIV protein integrase from inserting the viral DNA ge...
Retrovirology 2017 14:36
Published on: 5 June 2017
Short report
Simian immunodeficiency virus of chimpanzees (SIVcpz), the progenitor of human immunodeficiency virus type 1 (HIV-1), is associated with increased mortality and AIDS-like immunopathology in wild-living chimpan...
Retrovirology 2017 14:35
Published on: 2 June 2017
Research
Retroviral vectors are derived from wild-type retroviruses, can be used to study retrovirus-host interactions and are effective tools in gene and cell therapy. However, numerous cell types are resistant or les...
Retrovirology 2017 14:34
Published on: 31 May 2017
Research
Parent-offspring (PO) regression is a central tool to determine the heritability of phenotypic traits; i.e., the relative extent to which those traits are controlled by genetic factors. The applicability of PO...
Retrovirology 2017 14:33
Published on: 23 May 2017
Obituary
Retrovirology 2017 14:32
Published on: 22 May 2017
Review
Apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3 (APOBEC3) proteins are mammalian-specific cellular deaminases and have a robust ability to restrain lentivirus replication. To antagonize APOBE...
Retrovirology 2017 14:31
Published on: 8 May 2017
Editorial
Retrovirology 2017 14:30
Published on: 5 May 2017
Research
Ongoing intra-host HIV-1 evolution has been shown in individuals that naturally suppress the viremia to low levels (HIV controllers) by the analysis of the RNA in plasma compartment. Detection of evolution at ...
Retrovirology 2017 14:29
Published on: 2 May 2017
Short report
Retroviral envelope (Env) proteins are known to exhibit immunosuppressive properties, which become apparent not only in retroviral infections, but also in gene-based immunizations using retroviral immunogens, ...
Retrovirology 2017 14:28
Published on: 27 April 2017
Research
Human endogenous retroviruses (HERVs), the remnants of ancient retroviral infections, constitute approximately 8% of human genomic DNA. Since HERV-K Gag expression is induced by HIV-1 Tat in T cells, induced H...
Retrovirology 2017 14:27
Published on: 26 April 2017
Research
Although human T-lymphotropic virus type 1 (HTLV-1) infection is a prerequisite for the development of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), specific provirus mutations in HAM/TS...
Retrovirology 2017 14:26
Published on: 19 April 2017
Short report
APOBEC3/Rfv3 restricts acute Friend retrovirus (FV) infection and promotes virus-specific neutralizing antibody (NAb) responses. Classical Rfv3 studies utilized FV stocks containing lactate-dehydrogenase eleva...
Retrovirology 2017 14:25
Published on: 17 April 2017
Short report
Bovine leukemia virus (BLV) is the causative agent of enzootic bovine leukosis, a malignant B cell lymphoma that has spread worldwide and causes serious problems for the cattle industry. The BLV proviral load,...
Retrovirology 2017 14:24
Published on: 4 April 2017
Erratum
Retrovirology 2017 14:23
Published on: 27 March 2017
The original article was published in Retrovirology 2017 14:2
Commentary
It is well established that most new systemic infections of HIV-1 can be traced back to one or a limited number of founder viruses. Usually, these founders are more closely related to minor HIV-1 populations i...
Retrovirology 2017 14:22
Published on: 23 March 2017
Research
Human endogenous retroviruses (HERVs) are genomic sequences of retroviral origin which were believed to be integrated into germline chromosomes millions of years ago and account for nearly 8% of the human geno...
Retrovirology 2017 14:21
Published on: 22 March 2017
Research
Syncytin-1 and 2, human fusogenic glycoproteins encoded by the env genes of the endogenous retroviral loci ERVWE1 and ERVFRDE1, respectively, contribute to the differentiation of multinucleated syncytiotropho...
Retrovirology 2017 14:20
Published on: 17 March 2017
Research
HIV-1 Vif interacts with the cellular core-binding factor β (CBFβ) and counteracts the protective roles of certain human APOBEC3 (A3) proteins by targeting them for proteasomal degradation. Previous studies ha...
Retrovirology 2017 14:19
Published on: 17 March 2017
Research
BST2 inhibits HIV-1 release by tethering nascent virions to the surface of infected cells. HIV-1 Vpu overcomes this restriction by removing BST2 from viral budding sites via BST2 intracellular trapping and seq...
Retrovirology 2017 14:18
Published on: 14 March 2017
Research
Despite improved clinical outcomes seen following antiretroviral therapy (ART), resting CD4+ T cells continue to harbor latent human immunodeficiency virus type one (HIV-1). However, such cells are not likely ...
Retrovirology 2017 14:17
Published on: 9 March 2017
Short report
Prototype foamy virus (PFV) is a member of the Spumaretrovirinae subfamily of retroviruses, which maintains lifelong latent infection while being nonpathogenic to their natural hosts. Autophagy is a cell-progr...
Retrovirology 2017 14:16
Published on: 7 March 2017
Reply to correspondence
Retrovirology 2017 14:14
Published on: 24 February 2017
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