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Volume 8 Supplement 1

15th International Conference on Human Retroviruses: HTLV and Related Viruses

Association between Human T-Cell Lymphotropic Virus Type 1 and 2 (HTLV 1/2) infection and tuberculosis: systematic review and meta-analysis

Retrovirology volume 8, Article number: A80 (2011) Cite this article

Background

HTLV-1 infection alters the immune function and increases the risk of several infectious diseases. In this meta-analysis, we assess the association between HTLV- 1/2 and active tuberculosis (TB).

Methods

Four databases were searched for relevant articles that describe the frequency of HTLV- 1/2 infection among TB patients and control groups of healthy individuals or patients without a history of TB. Data were analyzed using the EasyMA software.

Results

The search yielded two hundred and eight articles. Six met the inclusion criteria and were included in the meta-analysis. The estimated relative risk of HTLV- 1/2 infection in TB patients was 3.25 times higher than in the population based control groups.

Conclusion

Patients with active TB have a higher risk of HTLV- 1/2 infection. Prospective studies involving latent tuberculosis infection (LTBI) in HTLV-1-infected individuals are necessary to evaluate the potential benefit of TB chemoprophylaxis.

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Authors and Affiliations

  1. Escola Bahiana de Medicina e Saúde Pública, Salvador, Bahia, Brazil

    Sérgio Arruda, Camila Loureiro, Marcos Almeida, Maria F R Grassi & Bernardo Galvão-Castro

  2. Laboratório Avançado de Saúde Pública, Centro de Pesquisas Gonçalo Moniz, Fiocruz, Salvador, Bahia, Brazil

    Sérgio Arruda, Dayana Mendes, Maria F R Grassi & Bernardo Galvão-Castro

  3. Universidade Federal do Rio de Janeiro,Faculdade de Medicina, RJ, Brazil

    José R Lapa & Afrânio Kritski

  4. Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru

    Kristien Verdonck & Eduardo Gotuzzo

  5. Institute of Tropical Medicine, Antwerp, Belgium

    Kristien Verdonck

Authors
  1. Sérgio Arruda
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  2. Camila Loureiro
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  3. Marcos Almeida
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  4. Dayana Mendes
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  5. Maria F R Grassi
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  6. José R Lapa
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  7. Afrânio Kritski
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  8. Kristien Verdonck
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  9. Eduardo Gotuzzo
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  10. Bernardo Galvão-Castro
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Corresponding author

Correspondence to Sérgio Arruda.

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This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Cite this article

Arruda, S., Loureiro, C., Almeida, M. et al. Association between Human T-Cell Lymphotropic Virus Type 1 and 2 (HTLV 1/2) infection and tuberculosis: systematic review and meta-analysis. Retrovirology 8 (Suppl 1), A80 (2011). https://doi.org/10.1186/1742-4690-8-S1-A80

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  • DOI: https://doi.org/10.1186/1742-4690-8-S1-A80

Keywords

  • Tuberculosis
  • Relative Risk
  • Healthy Individual
  • Immune Function
  • Virus Type

Retrovirology

ISSN: 1742-4690

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