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A specificity map for HTLV-1 Tax/PDZ interactions
Retrovirology volume 8, Article number: A162 (2011)
Human T-cell leukemia virus type I (HTLV-1) encodes a Tax oncoprotein that is critical for both viral replication and cellular transformation. HTLV-1 Tax possesses a PDZ domain binding motif (PBM) at its C-terminus that is essential for its transforming activity in a Rat-1 model and for IL-2. Tax has been shown to interact with several PDZ domain containing proteins including PSD-95, Beta1-syntrophin, the precursor of interleukin-16, the mammalian homolog of the Drosophila discs large tumor suppressor protein Dlg, PDLIM2, Lin7, hTid1, Tip1, hScrib and MAGI3. In the 15th International Conference on Human Retrovirology: HTLV and Related Retroviruses, we will present a specificity map for the Tax/PDZ domain interactions generated using the human ORFeome 5.1. and we will focus on some of the new Tax/PDZ interactions.
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This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Blibek, K., Twizere, J. A specificity map for HTLV-1 Tax/PDZ interactions. Retrovirology 8, A162 (2011). https://doi.org/10.1186/1742-4690-8-S1-A162
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Keywords
- Leukemia
- Leukemia Virus
- Domain Interaction
- Tumor Suppressor Protein
- Cellular Transformation
