- Meeting abstract
- Open Access
A specificity map for HTLV-1 Tax/PDZ interactions
- Karim Blibek1 and
- Jean-Claude Twizere2Email author
https://doi.org/10.1186/1742-4690-8-S1-A162
© Blibek and Twizere; licensee BioMed Central Ltd. 2011
Published: 6 June 2011
Keywords
- Leukemia
- Leukemia Virus
- Domain Interaction
- Tumor Suppressor Protein
- Cellular Transformation
Human T-cell leukemia virus type I (HTLV-1) encodes a Tax oncoprotein that is critical for both viral replication and cellular transformation. HTLV-1 Tax possesses a PDZ domain binding motif (PBM) at its C-terminus that is essential for its transforming activity in a Rat-1 model and for IL-2. Tax has been shown to interact with several PDZ domain containing proteins including PSD-95, Beta1-syntrophin, the precursor of interleukin-16, the mammalian homolog of the Drosophila discs large tumor suppressor protein Dlg, PDLIM2, Lin7, hTid1, Tip1, hScrib and MAGI3. In the 15th International Conference on Human Retrovirology: HTLV and Related Retroviruses, we will present a specificity map for the Tax/PDZ domain interactions generated using the human ORFeome 5.1. and we will focus on some of the new Tax/PDZ interactions.
Authors’ Affiliations
Copyright
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
