Volume 8 Supplement 1

15th International Conference on Human Retroviruses: HTLV and Related Viruses

Open Access

Neurological manifestations in HTLV-1 patients with overactive bladder syndrome. A precursor of HAM/TSP?

  • Davi Costa1Email author,
  • André Muniz dos Santos2,
  • Néviton Castro1,
  • Isadora Siqueira1,
  • Edgar Carvalho1 and
  • Marshall Glesby1
Retrovirology20118(Suppl 1):A78

https://doi.org/10.1186/1742-4690-8-S1-A78

Published: 6 June 2011

At least 20 million people are infected with HTLV-I virus in the world, and 3 to 5 % develop the classical neurological or hematological manifestations of myelopathy (HAM/TSP) or T-cell leukemia (ATLL). HTLV-I-infected patients with overactive bladder syndrome may represent 37%. We studied 102 HTLV-1 positive individuals without HAM/TSP divided into two groups according to the presence or absence of overactive bladder (OB) syndrome. Individuals with OB were more commonly female (84.3% vs. 60.8% of asymptomatics, P = 0.01), but the mean age in the two groups was similar (46.4 ± 1.9 vs. 42.3 ± 1.7 years, respectively; P = 0.11). The prevalence of neurological complaints was higher in OB group, especially hand or foot numbness and arm or leg weakness. There was no difference between the groups in neurological strength and reflexes. Weakness remained strongly associated with OB in multivariate logistic regression analysis adjusting for sex and age (adjusted odds ratio and 95% CI 3.59(1.45-8.88) in arms and 6.68(2.63-16.93) in legs). In summary, we have characterized a subgroup of HTLV-1 infected patients based on urinary complaints who have more frequent neurological symptoms compared to those without OB. Longitudinal studies are needed to determine if HTLV-1 associated OB is a precursor of HAM/TSP.

Authors’ Affiliations

(1)
Immunology, Universidade Federal da Bahia
(2)
Infectious Diseases, Cornell Weill Scholl of Medicine

Copyright

© Costa et al; licensee BioMed Central Ltd. 2011

This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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