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HTLV-I Tax inhibits innate antiviral signaling via NF-κB-dependent induction of SOCS1
Retrovirology volume 8, Article number: A191 (2011)
The human T cell leukemia virus type I (HTLV-I) inhibits host antiviral signaling pathways although the underlying mechanisms are unclear. Here we found that the HTLV-I Tax oncoprotein induced the expression of SOCS1, an inhibitor of interferon signaling. Tax required NF-κB, but not CREB, to induce the expression of SOCS1 in T cells. Furthermore, Tax interacted with SOCS1 in both transfected cells and in HTLV-I transformed cell lines. Although SOCS1 is normally a short-lived protein, in the presence of Tax, the stability of SOCS1 was greatly increased. Accordingly, Tax enhanced the replication of a heterologous virus, vesicular stomatitis virus (VSV), in a SOCS1-dependent manner. Surprisingly, Tax required SOCS1 to inhibit RIG-dependent antiviral signaling, but not the interferon-induced JAK/STAT pathway. Inhibition of SOCS1 by RNA-mediated interference in the HTLV-I transformed cell line MT-2 reduced HTLV-I replication and p19Gag levels. Taken together, our results reveal that Tax inhibits antiviral signaling, in part, by hijacking an interferon regulatory protein.
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This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Charoenthongtrakul, S., Zhou, Q., Shembade, N. et al. HTLV-I Tax inhibits innate antiviral signaling via NF-κB-dependent induction of SOCS1. Retrovirology 8 (Suppl 1), A191 (2011). https://doi.org/10.1186/1742-4690-8-S1-A191
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DOI: https://doi.org/10.1186/1742-4690-8-S1-A191
Keywords
- Leukemia
- Interferon
- Virus Type
- Stomatitis
- Leukemia Virus