Volume 11 Supplement 1

16th International Conference on Human Retroviruses: HTLV and Related Viruses

Meeting abstracts

Edited by Benoit Barbeau

Publication of this supplement was funded by the Canadian Institutes of Health Research (#201206). The Supplement Editor declares that he has no competing interests.

16th International Conference on Human Retroviruses: HTLV and Related Viruses. Go to conference site.

Montreal, Canada26-30 June 2013

Page 4 of 5

Suppression of type I interferon production by human T-cell leukemia virus type 1 oncoprotein Tax

Authors: Dong-Yan Jin, Kin-Hang Kok, Hei-Man V Tang, Pak-Yin Lui and Chi-Ping Chan

Citation: Retrovirology 2014 11(Suppl 1):P77

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A selective defect in Fas-mediated apoptosis in HAM/TSP: An ex vivo, in vitro and in silico study

Authors: Soraya Maria Menezes, Daniele Decanine, Ricardo Khouri, Saul Velloso Schnitman, Ramon A Kruschewsky, Anne-Mieke Vandamme, Bernardo Galvão-Castro and Johan Van Weyenbergh

Citation: Retrovirology 2014 11(Suppl 1):P78

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Frequency and function of KIR⁺ CD8⁺ T cells in HTLV-1 infection

Authors: Katie Twigger, Aileen Rowan, Nafisa-Katrin Seich al Basatena, Aidan MacNamara, Christelle Retiere, Keith Gould, Graham P Taylor, Becca Asquith and Charles RM Bangham

Citation: Retrovirology 2014 11(Suppl 1):P79

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Relation between mannose-binding lectin (MBL) gene codon 54 polymorphism (allele B) and susceptibility to HTLV-1 infection

Authors: María Saliba Pineda, Mirta Remesar, María Belén Bouzas, Ariel Fridman, Carlos Remondegui, Paula Aulicino, Luisa Sen and Andrea Mangano

Citation: Retrovirology 2014 11(Suppl 1):P80

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Epitopes recognised by neutralising and non-neutralising anti-envelope antibodies define surface exposed regions of HTLV-1 envelope

Authors: David W Brighty, Mariluz Arainga, Chien-Wen S Kuo and Abigail Fernades

Citation: Retrovirology 2014 11(Suppl 1):P81

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A novel tetrahydrotetramethylbenzophenanthridinone derivative inhibits ATL cell proliferation

Authors: Masaaki Toyama, Jun Takiguchi, Hiroshi Aoyama, Koji Yoshimura, Masaharu Nakamura, Yuichi Hashimoto and Masanori Baba

Citation: Retrovirology 2014 11(Suppl 1):P82

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Molecular characterization of human T-cell leukemia virus type 1 gp46 glycoprotein from healthy carriers and tropical spastic paraparesis/HTLV-associated myelopathy infected individuals

Authors: Aline CA Mota-Miranda, Fernanda K Barreto, Maria FC Amarante, Everton Baptista, Joana P Monteiro-Cunha, Lourdes Farre-Valve, Bernardo Galvao-Castro and Luiz CJ Alcantara

Citation: Retrovirology 2014 11(Suppl 1):P83

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Molecular study of HBZ and gp21 Human T cell lymphotropic virus type 1 proteins isolated from different clinical profile infected individuals

Authors: Aline CA Mota-Miranda, Fernanda K Barreto, Everton Baptista, Joana P Monteiro-Cunha, Lourdes Farre-Valve, Bernardo Galvao-Castro and Luiz CJ Alcantara

Citation: Retrovirology 2014 11(Suppl 1):P84

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Deep sequencing analysis of Human T cell lymphotropic virus type 1 (HTLV-1) long terminal repeat (LTR) region of tropical spastic paraparesis (TSP)/HTLV-1 associated myelopathy (HAM) and asymptomatic carriers

Authors: Filipe FA Rego, Tulio de Oliveira, Bernardo Galvão-Castro and Luiz CJ Alcantara

Citation: Retrovirology 2014 11(Suppl 1):P85

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A novel small-molecule SIRT1 inhibitor induces apoptosis in leukemic cell lines

Authors: Tomohiro Kozako, Takayoshi Suzuki, Makoto Yoshimitsu, Shohei Itonaga, Akiyoshi Aikawa, Shin-ichiro Honda, Naomichi Arima and Shinji Soeda

Citation: Retrovirology 2014 11(Suppl 1):P86

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NDRG2 plays a pivotal role in ATLL leukaemogenesis by regulating the PTEN-mediated PI3K/AKT signalling pathway

Authors: Shingo Nakahata, Tomonaga Ichikawa, Yusuke Saito, Yasuhito Arai, Tomohiko Taki, Masafumi Taniwaki and Kazuhiro Morishita

Citation: Retrovirology 2014 11(Suppl 1):P87

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Antagonistic effects of HTLV-1 Tax oncoprotein on BRCA1 expression and function

Authors: Mahmoud Huleihel, Mital Shukron, Azhar Gabarin, Ammar Abukandil and Mordechai Aboud

Citation: Retrovirology 2014 11(Suppl 1):P88

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Checkpoints modulation by the Human T-lymphotropic virus type 1 Tax protein

Authors: Alexandre Carpentier, Pierre-Yves Barez, Mathieu Boxus and Luc Willems

Citation: Retrovirology 2014 11(Suppl 1):P90

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HTLV-1-mediated dysregulation of the Wnt pathways: roles of Tax and HBZ

Authors: Guangyong Ma, Jun-ichiro Yasunaga, Jun Fan, Shin-ichi Yanagawa and Masao Matsuoka

Citation: Retrovirology 2014 11(Suppl 1):P91

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HTLV-1 bZIP factor suppresses c-Fos transcription and impairs T cell activation

Authors: Akihiro Kawatsuki, Jun-ichiro Yasunaga and Masao Matsuoka

Citation: Retrovirology 2014 11(Suppl 1):P92

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HTLV-1 Tax-activated NF-κB is involved in both cell growth and death

Authors: Mariko Mizuguchi, Masaya Higuchi, Masahiro Fujii and Masataka Nakamura

Citation: Retrovirology 2014 11(Suppl 1):P93

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Disorders of the cMyb proto-oncogene expression and its significance in the course of ATL development

Authors: Kazumi Nakano, Atae Utsunomiya, Kazunari Yamaguchi, Kaoru Uchimaru and Toshiki Watanabe

Citation: Retrovirology 2014 11(Suppl 1):P94

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Cooperation between the human T-cell leukemia virus type-1 p30(II) protein and host cellular factors during oncogenic transformation and retroviral carcinogenesis

Authors: Megan Romeo, Braden Barnett, Janice Kim, Paige Seeker, Jeffrey He, Alexander McRae, Fahmida Musharof, Hayley Heatley, Afrida Faria, Jennifer Tran, Jordan Milam and Robert Harrod

Citation: Retrovirology 2014 11(Suppl 1):P95

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The Tax protein and the minichromosome maintenance protein complex MCM2-7 affect cell replication and viral transcription

Authors: Pierre-Yves Barez, Alexandre Carpentier, Mathieu Boxus and Luc Willems

Citation: Retrovirology 2014 11(Suppl 1):P96

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HTLV Tax-1 and Tax-2 proteins enhance interferon regulatory factor 3 dependent promoter activation

Authors: Erica Diani, Francesca Avesani, Giorgia Cremonese, Elisa Bergamo, Umberto Bertazzoni and Maria Grazia Romanelli

Citation: Retrovirology 2014 11(Suppl 1):P97

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HTLV-1 Tax binds to and stabilizes the SUMO-targeted ubiquitin ligase RNF4 during DNA damage response

Authors: Xin Guo, Andrea Baillo, Sucharita M Dutta, Oliver Kerscher and O John Semmes

Citation: Retrovirology 2014 11(Suppl 1):P98

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Comparative infection of autologous primary T cells and monocytes derived DCs using cell-free virus preparation, viral biofilm, pseudotyped-virus or viral synapse

Authors: Sandrine Alais, Hélène Dutartre and Renaud Mahieux

Citation: Retrovirology 2014 11(Suppl 1):P99

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Antisense protein of HTLV-2 (APH-2) associates with PML nuclear bodies: molecular determinants and functional implications

Authors: Chloé Journo, Jocelyn Turpin, Estelle Douceron, Anaïs Oliva and Renaud Mahieux

Citation: Retrovirology 2014 11(Suppl 1):P100

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An interaction map for HTLV-1 Tax and PDZ-containing proteins

Authors: Karim Blibek, Xavier Rambout, Jérôme Beaufays, Laurence Lins, Franck Dequiedt and Jean-Claude Twizere

Citation: Retrovirology 2014 11(Suppl 1):P101

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TRAF5-mediated Tax ubiquitination modulates IKK phosphorylation but not binding to NEMO

Authors: Amandine Bonnet, Sabrina Pène, Laurence Bénit, Laetitia Waast, Ali Bazarbachi, Renaud Mahieux and Claudine Pique

Citation: Retrovirology 2014 11(Suppl 1):P102

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HTLV-1 Tax mediated downregulation of miRNAs associated with chromatin remodeling factors in T cells with stably integrated viral promoter

Authors: Saifur Rahman, Kevin Quann, Devanshi Pandya, Shruti Singh, Zafar K Khan and Pooja Jain

Citation: Retrovirology 2014 11(Suppl 1):P103

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Inhibition of Tax transformation activity using a small molecule targeting Tax/PDZ domain interactions

Authors: Karim Blibek, Naoaki Fujii, Sebastien Legros, Mathieu Boxus, Jean-François Dewulf, Pascale Zimmermann, Richard Kettmann, Franck Dequiedt and Jean-Claude Twizere

Citation: Retrovirology 2014 11(Suppl 1):P104

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Development and validation of a Multiplex Real-Time PCR for HTLV-1/2 confirmatory diagnosis

Authors: Maurício Cristiano Rocha Júnior, Rodrigo Haddad, Virginia Mara de Deus Wagatsuma, Oswaldo Massaiti Takayanagui, Svetoslav Nanev Slavov, Katia Kaori Otaguiri, Evandra Strazza Rodrigues, Dimas Tadeu Covas and Simone Kashima

Citation: Retrovirology 2014 11(Suppl 1):P105

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HTLV-1 infection in bone marrow mesenchymal stem cells isolated from HTLV-1 individuals

Authors: Evandra Strazza Rodrigues, Maria do Carmo Favarin, Mayra Dorigan de Macedo, Kátia Kaori Otaguiri, Maristela Delgado Orellana, Osvaldo Massaiti Takayanagui, Patrícia Vianna Bonini Palma, Gil Cunha de Santis, Dimas Tadeu Covas and Simone Kashima

Citation: Retrovirology 2014 11(Suppl 1):P106

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Tax inflicts DNA damage through activation of Nitric Oxide production

Authors: Hicham H Baydoun and Lee Ratner

Citation: Retrovirology 2014 11(Suppl 1):P107

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Identification and characterization of new Sp1 sites located in the R region of the Human T-lymphotropic virus 1 (HTLV-1) long terminal repeat

Authors: Benoit Van Driessche, Gwenaëlle Robette, Caroline Vanhulle, Arsène Burny, Olivier Rohr and Carine Van Lint

Citation: Retrovirology 2014 11(Suppl 1):P108

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Inhibition of histone acetyltransferase (HAT) activity by HBZ extends beyond the p300/CBP HAT family

Authors: Diana G Wright, Nicholas Polakowski and Isabelle Lemasson

Citation: Retrovirology 2014 11(Suppl 1):P109

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Molecular characterization of a Tax-2C protein variant identified in Brazilian subjects infected by HTLV-2C

Authors: Adele Caterino-de-Araujo, Mariana Cavalheiro Magri, Umberto Bertazzoni and Maria Grazia Romanelli

Citation: Retrovirology 2014 11(Suppl 1):P110

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MicroRNAs expression in CD4 T cells from HTLV-1 individuals

Authors: Kátia Kaori Otaguiri, Mariana Tomazini Pinto, Evandra Strazza Rodrigues, Virgínia Mara de Deus Wagatsuma, Maurício Cristiano Rocha Júnior, Osvaldo Massaiti Takayanagui, Dimas Tadeu Covas and Simone Kashima

Citation: Retrovirology 2014 11(Suppl 1):P111

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Metformin inhibits human T-cell leukemia virus type 1 transcription through activation of LKB1 and salt-inducible kinases

Authors: Hei-Man V Tang, Wei-Wei Gao, Ching-Ping Chan, Yeung-Tung Siu, Chi-Ming Wong, Kin-Hang Kok, Yick-Pang Ching, Hiroshi Takemori and Dong-Yan Jin

Citation: Retrovirology 2014 11(Suppl 1):P112

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Investigation of the role of nuclear factors associated with double-stranded RNA protein members in the pathogenesis of HTLV-2

Authors: Jane L Murphy, William W Hall and Noreen Sheehy

Citation: Retrovirology 2014 11(Suppl 1):P113

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A role for RNA stability in the induction of HTLV-1 expression in chronically-infected CD4+ T cells

Authors: Hsin-Ching Lin, Peter Simon and Arnold B Rabson

Citation: Retrovirology 2014 11(Suppl 1):P114

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Tax promotes the expression of the alternative spliced isoform CD44v10 by slowing down the elongating RNA polymerase II

Authors: Morgan Thenoz, Céline Vernin, Christiane Pinatel, Nicolas Nazaret, Joel Lachuer, Antoine Gessain, Didier Auboeuf, Eric Wattel and Franck Mortreux

Citation: Retrovirology 2014 11(Suppl 1):P115

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The antisense protein of HTLV-2 positively modulates HIV-1 replication

Authors: Cynthia Torresilla, Sonia Do Carmo, Émilie Larocque, Estelle Douceron, Jean-Michel Mesnard, Renaud Mahieux and Benoit Barbeau

Citation: Retrovirology 2014 11(Suppl 1):P118

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Recurrent TET2 mutations in adult T cell leukemia

Authors: Ambroise Marçais, Katia Hanssens, Lucy Cook, Thomas Mercher, Philippe Gaulard, Vahid Asnafi, Claudine Pique, Ali Bazarbachi, Felipe Suarez, Olivier Bernard, Charles RM Bangham, Patrice Dubreuil and Olivier Hermine

Citation: Retrovirology 2014 11(Suppl 1):P119

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Modulation of spontaneous proliferation of T-lymphocytes from HTLV-1- infected individuals by quinoline compounds

Authors: Lorena A Pinto, Marcos A Vannier-Santos, Alain Fournet, Bernardo Galvão-Castro and Maria FR Grassi

Citation: Retrovirology 2014 11(Suppl 1):P121

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Role of regulatory proteins in HIV-1/HTLV-1 coinfection

Authors: Dustin Edwards, Klaus Strebel, Robyn Washington Parks, Cynthia Pise-Masison, Claudio Fenizia, Martina Fiocchi and Genoveffa Franchini

Citation: Retrovirology 2014 11(Suppl 1):P122

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The contribution of monocytes/macrophages to HTLV-1 infection and persistence

Authors: Maria Fernanda de Castro-Amarante, Cynthia Pise-Masison, Katherine McKinnon, Raya Massoud, Steven Jacobson and Genoveffa Franchini

Citation: Retrovirology 2014 11(Suppl 1):P123

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Role of HTLV-1 p30 during infection of monocytes and dendritic cells

Authors: Claudio Fenizia, Martina Fiocchi, Kathryn Jones, Robyn Washington Parks, Sebastien A Chevalier, Frank Ruscetti, Cynthia Pise-Masison and Genoveffa Franchini

Citation: Retrovirology 2014 11(Suppl 1):P124

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Differential expression in genes involved in the NF-κβ pathway among asymptomatic HTLV-1 carriers and HAM/TSP patients in Peru

Authors: Michael Talledo, Jason Rosado, Carolina Alvarez, Daniel Clark and Eduardo Gotuzzo

Citation: Retrovirology 2014 11(Suppl 1):P126

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Proteomic profiles among asymptomatic HTLV-1 carriers and HAM/TSP patients in Peru

Authors: Morayma Temoche, Jason Rosado, Carolina Alvarez, Daniel Clark, Eduardo Gotuzzo and Michael Talledo

Citation: Retrovirology 2014 11(Suppl 1):P127

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Differential miRNA expression profiles in Peruvian HTLV-1 carriers

Authors: Jason Rosado, Carolina Alvarez, Daniel Clark, Eduardo Gotuzzo and Michael Talledo

Citation: Retrovirology 2014 11(Suppl 1):P128

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Differential CD30 expression in adult T-cell leukemia-lymphoma subtypes

Authors: Germán Campuzano-Zuluaga, Agustin Pimentel, Jennifer R Chapman-Fredricks and Juan Carlos Ramos

Citation: Retrovirology 2014 11(Suppl 1):P129

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Examination of the interactions between the HTLV-1-encoded Tax oncoprotein and the cellular coactivators CBP/p300

Authors: Alisha D Howard and Jennifer K Nyborg

Citation: Retrovirology 2014 11(Suppl 1):P130

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HERV-W/MRSV envelope transcripts detection in blood of multiple sclerosis patients after Natalizumab treatment

Authors: Luiz HS Nali, Guilherme S Olival, Augusto CP de Oliveira, Jorge Casseb, Jose E Vidal, Lenira Moraes, Maria CD Fink, Laura M Sumita and Camila M Romano

Citation: Retrovirology 2014 11(Suppl 1):P131

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16th International Conference on Human Retroviruses: HTLV and Related Viruses

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