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The Tax protein and the minichromosome maintenance protein complex MCM2-7 affect cell replication and viral transcription

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The Tax oncoprotein plays a key role in the mechanisms of transformation, viral persistence and pathogenicity. Recently, we showed that Tax interacts with the minichromosome maintenance MCM2-7 helicase and binds to origins of DNA replication (Boxus et al, 2012 Blood 119:151). In fact, Tax modulates the spatiotemporal program of origin activation during the S phase of cell cycle. By this mechanism, Tax accelerates S phase progression through early firing of late replication origins. By interacting with the 5’ LTR, the MCM2-7 complex also modulates Tax transactivation. Together, our data thus demonstrates that interaction between Tax and MCM2-7 modulates reprogramming of replication origins as well as viral transcription.

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Correspondence to Pierre-Yves Barez.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Barez, P., Carpentier, A., Boxus, M. et al. The Tax protein and the minichromosome maintenance protein complex MCM2-7 affect cell replication and viral transcription. Retrovirology 11, P96 (2014) doi:10.1186/1742-4690-11-S1-P96

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Keywords

  • Replication Origin
  • Origin Activation
  • Cell Replication
  • Viral Persistence
  • Affect Cell