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  • Open Access

The Tax protein and the minichromosome maintenance protein complex MCM2-7 affect cell replication and viral transcription

  • 1, 2Email author,
  • 1, 2,
  • 1, 2 and
  • 1, 2
Retrovirology201411 (Suppl 1) :P96

https://doi.org/10.1186/1742-4690-11-S1-P96

  • Published:

Keywords

  • Replication Origin
  • Origin Activation
  • Cell Replication
  • Viral Persistence
  • Affect Cell

The Tax oncoprotein plays a key role in the mechanisms of transformation, viral persistence and pathogenicity. Recently, we showed that Tax interacts with the minichromosome maintenance MCM2-7 helicase and binds to origins of DNA replication (Boxus et al, 2012 Blood 119:151). In fact, Tax modulates the spatiotemporal program of origin activation during the S phase of cell cycle. By this mechanism, Tax accelerates S phase progression through early firing of late replication origins. By interacting with the 5’ LTR, the MCM2-7 complex also modulates Tax transactivation. Together, our data thus demonstrates that interaction between Tax and MCM2-7 modulates reprogramming of replication origins as well as viral transcription.

Authors’ Affiliations

(1)
Molecular and cellular Epigenetics, Interdisciplinary Cluster for Applied Genoproteomics (GIGA), University of Liège (ULg), Liège, Belgium
(2)
Molecular Biology Lab, Gembloux Agro Bio-Tech (ULg), Gembloux, Belgium

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