Volume 11 Supplement 1
The Tax protein and the minichromosome maintenance protein complex MCM2-7 affect cell replication and viral transcription
© Barez et al; licensee BioMed Central Ltd. 2014
Published: 7 January 2014
The Tax oncoprotein plays a key role in the mechanisms of transformation, viral persistence and pathogenicity. Recently, we showed that Tax interacts with the minichromosome maintenance MCM2-7 helicase and binds to origins of DNA replication (Boxus et al, 2012 Blood 119:151). In fact, Tax modulates the spatiotemporal program of origin activation during the S phase of cell cycle. By this mechanism, Tax accelerates S phase progression through early firing of late replication origins. By interacting with the 5’ LTR, the MCM2-7 complex also modulates Tax transactivation. Together, our data thus demonstrates that interaction between Tax and MCM2-7 modulates reprogramming of replication origins as well as viral transcription.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.