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Retrovirology

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  1. Content type: Research

    The HIV-1 RNA genome has a biased nucleotide composition with a surplus of As. Several hypotheses have been put forward to explain this striking phenomenon, but the A-count of the HIV-1 genome has thus far not...

    Authors: Bep Klaver, Yme van der Velden, Formijn van Hemert, Antoinette C. van der Kuyl and Ben Berkhout

    Citation: Retrovirology 2017 14:43

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  2. Content type: Research

    Myeloid-derived suppressor cells (MDSCs) can suppress T cell responses in several different diseases. Previously these suppressive cells were observed to expand in HIV patients and in a mouse retrovirus model,...

    Authors: Malgorzata Drabczyk-Pluta, Tanja Werner, Daniel Hoffmann, Qibin Leng, Lieping Chen, Ulf Dittmer and Gennadiy Zelinskyy

    Citation: Retrovirology 2017 14:42

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  3. Content type: Research

    Rev-like proteins are post-transcriptional regulatory proteins found in several retrovirus genera, including lentiviruses, betaretroviruses, and deltaretroviruses. These essential proteins mediate the nuclear ...

    Authors: Chijioke N. Umunnakwe, Karin S. Dorman, Drena Dobbs and Susan Carpenter

    Citation: Retrovirology 2017 14:40

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  4. Content type: Research

    Human endogenous retroviruses (HERVs) comprise approximately 8% of the human genome and while the majority are transcriptionally silent, the most recently integrated HERV, HERV-K (HML-2), remains active. Durin...

    Authors: Miguel de Mulder, Devi SenGupta, Steven G. Deeks, Jeffrey N. Martin, Christopher D. Pilcher, Frederick M. Hecht, Jonah B. Sacha, Douglas F. Nixon and Henri-Alexandre Michaud

    Citation: Retrovirology 2017 14:41

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  5. Content type: Research

    Insertion of retroviral genome DNA occurs in the chromatin of the host cell. This step is modulated by chromatin structure as nucleosomes compaction was shown to prevent HIV-1 integration and chromatin remodel...

    Authors: Julien Matysiak, Paul Lesbats, Eric Mauro, Delphine Lapaillerie, Jean-William Dupuy, Angelica P. Lopez, Mohamed Salah Benleulmi, Christina Calmels, Marie-Line Andreola, Marc Ruff, Manuel Llano, Olivier Delelis, Marc Lavigne and Vincent Parissi

    Citation: Retrovirology 2017 14:39

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  6. Content type: Review

    Integrase strand transfer inhibitors (INSTIs) are the newest class of antiretroviral drugs to be approved for treatment and act by inhibiting the essential HIV protein integrase from inserting the viral DNA ge...

    Authors: Kaitlin Anstett, Bluma Brenner, Thibault Mesplede and Mark A. Wainberg

    Citation: Retrovirology 2017 14:36

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  7. Content type: Short report

    Simian immunodeficiency virus of chimpanzees (SIVcpz), the progenitor of human immunodeficiency virus type 1 (HIV-1), is associated with increased mortality and AIDS-like immunopathology in wild-living chimpan...

    Authors: Hannah J. Barbian, Raven Jackson-Jewett, Corrine S. Brown, Frederic Bibollet-Ruche, Gerald H. Learn, Timothy Decker, Edward F. Kreider, Yingying Li, Thomas N. Denny, Paul M. Sharp, George M. Shaw, Jeffrey Lifson, Edward P. Acosta, Michael S. Saag, Katharine J. Bar and Beatrice H. Hahn

    Citation: Retrovirology 2017 14:35

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  8. Content type: Research

    Retroviral vectors are derived from wild-type retroviruses, can be used to study retrovirus-host interactions and are effective tools in gene and cell therapy. However, numerous cell types are resistant or les...

    Authors: Franziska K. Geis, Melanie Galla, Dirk Hoffmann, Johannes Kuehle, Daniela Zychlinski, Tobias Maetzig, Juliane W. Schott, Adrian Schwarzer, Christine Goffinet, Stephen P. Goff and Axel Schambach

    Citation: Retrovirology 2017 14:34

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    The Correction to this article has been published in Retrovirology 2017 14:48

  9. Content type: Research

    Parent-offspring (PO) regression is a central tool to determine the heritability of phenotypic traits; i.e., the relative extent to which those traits are controlled by genetic factors. The applicability of PO...

    Authors: Nadine Bachmann, Teja Turk, Claus Kadelka, Alex Marzel, Mohaned Shilaih, Jürg Böni, Vincent Aubert, Thomas Klimkait, Gabriel E. Leventhal, Huldrych F. Günthard and Roger Kouyos

    Citation: Retrovirology 2017 14:33

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  10. Content type: Review

    Apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3 (APOBEC3) proteins are mammalian-specific cellular deaminases and have a robust ability to restrain lentivirus replication. To antagonize APOBE...

    Authors: Yusuke Nakano, Hirofumi Aso, Andrew Soper, Eri Yamada, Miyu Moriwaki, Guillermo Juarez-Fernandez, Yoshio Koyanagi and Kei Sato

    Citation: Retrovirology 2017 14:31

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  11. Content type: Editorial

    Authors: Monsef Benkirane, Ben Berkhout, Persephone Borrow, Ariberto Fassati, Masahiro Fujii, J. Victor Garcia, Paul Gorry, Andrew Lever, Johnson Mak, Monique Nijhuis, Klaus Strebel, Francois Venter and Robin Weiss

    Citation: Retrovirology 2017 14:30

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  12. Content type: Research

    Ongoing intra-host HIV-1 evolution has been shown in individuals that naturally suppress the viremia to low levels (HIV controllers) by the analysis of the RNA in plasma compartment. Detection of evolution at ...

    Authors: Suwellen S. D. de Azevedo, Diogo Gama Caetano, Fernanda H. Côrtes, Sylvia L. M. Teixeira, Karina dos Santos Silva, Brenda Hoagland, Beatriz Grinsztejn, Valdilea G. Veloso, Mariza G. Morgado and Gonzalo Bello

    Citation: Retrovirology 2017 14:29

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  13. Content type: Short report

    Retroviral envelope (Env) proteins are known to exhibit immunosuppressive properties, which become apparent not only in retroviral infections, but also in gene-based immunizations using retroviral immunogens, ...

    Authors: Nadine Bongard, Dennis Lapuente, Sonja Windmann, Ulf Dittmer, Matthias Tenbusch and Wibke Bayer

    Citation: Retrovirology 2017 14:28

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  14. Content type: Research

    Human endogenous retroviruses (HERVs), the remnants of ancient retroviral infections, constitute approximately 8% of human genomic DNA. Since HERV-K Gag expression is induced by HIV-1 Tat in T cells, induced H...

    Authors: Kazuaki Monde, Hiromi Terasawa, Yusuke Nakano, Ferri Soheilian, Kunio Nagashima, Yosuke Maeda and Akira Ono

    Citation: Retrovirology 2017 14:27

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  15. Content type: Research

    Although human T-lymphotropic virus type 1 (HTLV-1) infection is a prerequisite for the development of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), specific provirus mutations in HAM/TS...

    Authors: Satoshi Nozuma, Eiji Matsuura, Daisuke Kodama, Yuichi Tashiro, Toshio Matsuzaki, Ryuji Kubota, Shuji Izumo and Hiroshi Takashima

    Citation: Retrovirology 2017 14:26

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  16. Content type: Short report

    APOBEC3/Rfv3 restricts acute Friend retrovirus (FV) infection and promotes virus-specific neutralizing antibody (NAb) responses. Classical Rfv3 studies utilized FV stocks containing lactate-dehydrogenase eleva...

    Authors: Bradley S. Barrett, Michael S. Harper, Sean T. Jones, Kejun Guo, Karl J. Heilman, Ross M. Kedl, Kim J. Hasenkrug and Mario L. Santiago

    Citation: Retrovirology 2017 14:25

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  17. Content type: Short report

    Bovine leukemia virus (BLV) is the causative agent of enzootic bovine leukosis, a malignant B cell lymphoma that has spread worldwide and causes serious problems for the cattle industry. The BLV proviral load,...

    Authors: Shin-nosuke Takeshima, Shinji Sasaki, Polat Meripet, Yoshikazu Sugimoto and Yoko Aida

    Citation: Retrovirology 2017 14:24

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  18. Content type: Commentary

    It is well established that most new systemic infections of HIV-1 can be traced back to one or a limited number of founder viruses. Usually, these founders are more closely related to minor HIV-1 populations i...

    Authors: Samuel Mundia Kariuki, Philippe Selhorst, Kevin K. Ariën and Jeffrey R. Dorfman

    Citation: Retrovirology 2017 14:22

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  19. Content type: Research

    Human endogenous retroviruses (HERVs) are genomic sequences of retroviral origin which were believed to be integrated into germline chromosomes millions of years ago and account for nearly 8% of the human geno...

    Authors: Richa Tyagi, Wenxue Li, Danelvis Parades, Mario A. Bianchet and Avindra Nath

    Citation: Retrovirology 2017 14:21

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  20. Content type: Research

    Syncytin-1 and 2, human fusogenic glycoproteins encoded by the env genes of the endogenous retroviral loci ERVWE1 and ERVFRDE1, respectively, contribute to the differentiation of multinucleated syncytiotropho...

    Authors: Martina Benešová, Kateřina Trejbalová, Denisa Kovářová, Zdenka Vernerová, Tomáš Hron, Dana Kučerová and Jiří Hejnar

    Citation: Retrovirology 2017 14:20

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  21. Content type: Research

    HIV-1 Vif interacts with the cellular core-binding factor β (CBFβ) and counteracts the protective roles of certain human APOBEC3 (A3) proteins by targeting them for proteasomal degradation. Previous studies ha...

    Authors: Belete A. Desimmie, Jessica L. Smith, Hiroshi Matsuo, Wei-Shau Hu and Vinay K. Pathak

    Citation: Retrovirology 2017 14:19

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