Campbell EM, Hope TJ. HIV-1 capsid: the multifaceted key player in HIV-1 infection. Nat Rev Microbiol. 2015;13:471–83.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ganser-Pornillos BK, Yeager M, Pornillos O. Assembly and architecture of HIV. Adv Exp Med Biol. 2012;726:441–65.
Article
CAS
PubMed
PubMed Central
Google Scholar
Perilla JR, Gronenborn AM. Molecular architecture of the retroviral capsid. Trends Biochem Sci. 2016;41:410–20.
Article
CAS
PubMed
PubMed Central
Google Scholar
Fassati A. Multiple roles of the capsid protein in the early steps of HIV-1 infection. Virus Res. 2012;170:15–24.
Article
CAS
PubMed
Google Scholar
Novikova M, Zhang Y, Freed EO, Peng K. Multiple roles of HIV-1 capsid during the virus replication cycle. Virol Sin. 2019;34:119–34.
Article
CAS
PubMed
PubMed Central
Google Scholar
Scoca V, Di Nunzio F. The HIV-1 capsid: from structural component to key factor for host nuclear invasion. Viruses. 2021;13:273.
Article
CAS
PubMed
PubMed Central
Google Scholar
Arhel N. Revisiting HIV-1 uncoating. Retrovirology. 2010;7:96.
Article
PubMed
PubMed Central
CAS
Google Scholar
Ambrose Z, Aiken C. HIV-1 uncoating: connection to nuclear entry and regulation by host proteins. Virology. 2014;454–455:371–9.
Article
PubMed
CAS
Google Scholar
Yamashita M, Engelman AN. Capsid-dependent host factors in HIV-1 infection. Trends Microbiol. 2017;25:741–55.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wilbourne M, Zhang P. Visualizing HIV-1 capsid and its interactions with antivirals and host factors. Viruses. 2021;13:246.
Article
CAS
PubMed
PubMed Central
Google Scholar
Temple J, Tripler TN, Shen Q, Xiong Y. A snapshot of HIV-1 capsid–host interactions. Curr Res Struct Biol. 2020;2:222–8.
Article
PubMed
PubMed Central
Google Scholar
Thenin-Houssier S, Valente ST. HIV-1 capsid inhibitors as antiretroviral agents. Curr HIV Res. 2016;14:270–82.
Article
CAS
PubMed
PubMed Central
Google Scholar
Carnes SK, Sheehan JH, Aiken C. Inhibitors of the HIV-1 capsid, a target of opportunity. Curr Opin HIV AIDS. 2018;13:359–65.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ganser-Pornillos BK, Yeager M, Sundquist WI. The structural biology of HIV assembly. Curr Opin Struct Biol. 2008;18:203–17.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zhang W, Cao S, Martin JL, Mueller JD, Mansky LM. Morphology and ultrastructure of retrovirus particles. AIMS Biophys. 2015;2:343–69.
Article
CAS
PubMed
PubMed Central
Google Scholar
Sundquist WI, Kräusslich H-G. HIV-1 assembly, budding, and maturation. Cold Spring Harbor Perspect Med. 2012;2:a006924.
Article
CAS
Google Scholar
Freed EO. HIV-1 assembly, release and maturation. Nat Rev Microbiol. 2015;13:484–96.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wang CT, Barklis E. Assembly, processing, and infectivity of human immunodeficiency virus type 1 gag mutants. J Virol. 1993;67:4264–73.
Article
CAS
PubMed
PubMed Central
Google Scholar
Dorfman T, Bukovsky A, Ohagen A, Höglund S, Göttlinger HG. Functional domains of the capsid protein of human immunodeficiency virus type 1. J Virol. 1994;68:8180–7.
Article
CAS
PubMed
PubMed Central
Google Scholar
Reicin AS, Paik S, Berkowitz RD, Luban J, Lowy I, Goff SP. Linker insertion mutations in the human immunodeficiency virus type 1 gag gene: effects on virion particle assembly, release, and infectivity. J Virol. 1995;69:642–50.
Article
CAS
PubMed
PubMed Central
Google Scholar
Fitzon T, Leschonsky B, Bieler K, Paulus C, Schröder J, Wolf H, Wagner R. Proline residues in the HIV-1 NH2-terminal capsid domain: structure determinants for proper core assembly and subsequent steps of early replication. Virology. 2000;268:294–307.
Article
CAS
PubMed
Google Scholar
von Schwedler UK, Stray KM, Garrus JE, Sundquist WI. Functional surfaces of the human immunodeficiency virus type 1 capsid protein. J Virol. 2003;77:5439–50.
Article
CAS
Google Scholar
Manocheewa S, Swain JV, Lanxon-Cookson E, Rolland M, Mullins JI. Fitness costs of mutations at the HIV-1 capsid hexamerization interface. PLoS ONE. 2013;8:e66065.
Article
CAS
PubMed
PubMed Central
Google Scholar
Rihn SJ, Wilson SJ, Loman NJ, Alim M, Bakker SE, Bhella D, Gifford RJ, Rixon FJ, Bieniasz PD. Extreme genetic fragility of the HIV-1 capsid. PLoS Pathog. 2013;9:e1003461.
Article
CAS
PubMed
PubMed Central
Google Scholar
Gamble TR, Yoo S, Vajdos FF, von Schwedler UK, Worthylake DK, Wang H, McCutcheon JP, Sundquist WI, Hill CP. Structure of the carboxyl-terminal dimerization domain of the HIV-1 capsid protein. Science. 1997;278:849–53.
Article
CAS
PubMed
Google Scholar
Accola MA, Höglund S, Göttlinger HG. A putative alpha-helical structure which overlaps the capsid-p2 boundary in the human immunodeficiency virus type 1 Gag precursor is crucial for viral particle assembly. J Virol. 1998;72:2072–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Liang C, Hu J, Russell RS, Roldan A, Kleiman L, Wainberg MA. Characterization of a putative alpha-helix across the capsid-SP1 boundary that is critical for the multimerization of human immunodeficiency virus type 1 gag. J Virol. 2002;76:11729–37.
Article
CAS
PubMed
PubMed Central
Google Scholar
Liang C, Hu J, Whitney JB, Kleiman L, Wainberg MA. A structurally disordered region at the C terminus of capsid plays essential roles in multimerization and membrane binding of the gag protein of human immunodeficiency virus type 1. J Virol. 2003;77:1772–83.
Article
PubMed
PubMed Central
CAS
Google Scholar
Abdurahman S, Höglund S, Goobar-Larsson L, Vahlne A. Selected amino acid substitutions in the C-terminal region of human immunodeficiency virus type 1 capsid protein affect virus assembly and release. J Gen Virol. 2004;85:2903–13.
Article
CAS
PubMed
Google Scholar
Melamed D, Mark-Danieli M, Kenan-Eichler M, Kraus O, Castiel A, Laham N, Pupko T, Glaser F, Ben-Tal N, Bacharach E. The conserved carboxy terminus of the capsid domain of human immunodeficiency virus type 1 gag protein is important for virion assembly and release. J Virol. 2004;78:9675–88.
Article
CAS
PubMed
PubMed Central
Google Scholar
Strambio-de-Castillia C, Hunter E. Mutational analysis of the major homology region of Mason-Pfizer monkey virus by use of saturation mutagenesis. J Virol. 1992;66:7021–32.
Article
CAS
PubMed
PubMed Central
Google Scholar
Mammano F, Ohagen A, Höglund S, Göttlinger HG. Role of the major homology region of human immunodeficiency virus type 1 in virion morphogenesis. J Virol. 1994;68:4927–36.
Article
CAS
PubMed
PubMed Central
Google Scholar
Craven RC, Leure-duPree AE, Weldon RA, Wills JW. Genetic analysis of the major homology region of the Rous sarcoma virus Gag protein. J Virol. 1995;69:4213–27.
Article
CAS
PubMed
PubMed Central
Google Scholar
Chang Y-F, Wang S-M, Huang K-J, Wang C-T. Mutations in capsid major homology region affect assembly and membrane affinity of HIV-1 Gag. J Mol Biol. 2007;370:585–97.
Article
CAS
PubMed
Google Scholar
Tanaka M, Robinson BA, Chutiraka K, Geary CD, Reed JC, Lingappa JR. Mutations of conserved residues in the major homology region arrest assembling HIV-1 gag as a membrane-targeted intermediate containing genomic RNA and cellular proteins. J Virol. 2016;90:1944–63.
Article
CAS
PubMed
PubMed Central
Google Scholar
Novikova M, Adams LJ, Fontana J, Gres AT, Balasubramaniam M, Winkler DC, Kudchodkar SB, Soheilian F, Sarafianos SG, Steven AC, Freed EO. Identification of a structural element in HIV-1 gag required for virus particle assembly and maturation. mBio 2018;9.
Wagner JM, Zadrozny KK, Chrustowicz J, Purdy MD, Yeager M, Ganser-Pornillos BK, Pornillos O. Crystal structure of an HIV assembly and maturation switch. eLife. 2016;5.
Kucharska I, Ding P, Zadrozny KK, Dick RA, Summers MF, Ganser-Pornillos BK, Pornillos O. Biochemical reconstitution of HIV-1 assembly and maturation. J Virol. 2020;94.
Joshi A, Nagashima K, Freed EO. Mutation of dileucine-like motifs in the human immunodeficiency virus type 1 capsid disrupts virus assembly, gag–gag interactions, gag-membrane binding, and virion maturation. J Virol. 2006;80:7939–51.
Article
CAS
PubMed
PubMed Central
Google Scholar
Robinson BA, Reed JC, Geary CD, Swain JV, Lingappa JR. A temporospatial map that defines specific steps at which critical surfaces in the Gag MA and CA domains act during immature HIV-1 capsid assembly in cells. J Virol. 2014;88:5718–41.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lingappa JR, Reed JC, Tanaka M, Chutiraka K, Robinson BA. How HIV-1 Gag assembles in cells: putting together pieces of the puzzle. Virus Res. 2014;193:89–107.
Article
CAS
PubMed
PubMed Central
Google Scholar
Dick RA, Mallery DL, Vogt VM, James LC. IP6 regulation of HIV capsid assembly, stability, and uncoating. Viruses. 2018;10:640.
Article
CAS
PubMed Central
Google Scholar
Dostálková A, Kaufman F, Křížová I, Vokatá B, Ruml T, Rumlová M. In vitro quantification of the effects of IP6 and other small polyanions on immature HIV-1 particle assembly and core stability. J Virol. 2020;94.
Sowd GA, Aiken C. Inositol phosphates promote HIV-1 assembly and maturation to facilitate viral spread in human CD4+ T cells. PLoS Pathog. 2021;17:e1009190.
Article
CAS
PubMed
PubMed Central
Google Scholar
Dick RA, Zadrozny KK, Xu C, Schur FKM, Lyddon TD, Ricana CL, Wagner JM, Perilla JR, Ganser-Pornillos BK, Johnson MC, et al. Inositol phosphates are assembly co-factors for HIV-1. Nature. 2018;560:509–12.
Article
CAS
PubMed
PubMed Central
Google Scholar
Mallery DL, Faysal KMR, Kleinpeter A, Wilson MSC, Vaysburd M, Fletcher AJ, Novikova M, Böcking T, Freed EO, Saiardi A, James LC. Cellular IP6 levels limit HIV production while viruses that cannot efficiently package IP6 are attenuated for infection and replication. Cell Rep. 2019;29:3983-3996.e3984.
Article
CAS
PubMed
PubMed Central
Google Scholar
Mallery DL, Kleinpeter AB, Renner N, Faysal KMR, Novikova M, Kiss L, Wilson MSC, Ahsan B, Ke Z, Briggs JAG, et al. A stable immature lattice packages IP6 for HIV capsid maturation. Sci Adv. 2021;7.
Poston D, Zang T, Bieniasz P. Derivation and characterization of an HIV-1 mutant that rescues IP6 binding deficiency. Retrovirology. 2021;18:25.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ricana CL, Lyddon TD, Dick RA, Johnson MC. Primate lentiviruses require Inositol hexakisphosphate (IP6) or inositol pentakisphosphate (IP5) for the production of viral particles. PLoS Pathog. 2020;16:e1008646.
Article
CAS
PubMed
PubMed Central
Google Scholar
Dick RA, Xu C, Morado DR, Kravchuk V, Ricana CL, Lyddon TD, Broad AM, Feathers JR, Johnson MC, Vogt VM, et al. Structures of immature EIAV Gag lattices reveal a conserved role for IP6 in lentivirus assembly. PLoS Pathog. 2020;16:e1008277.
Article
PubMed
PubMed Central
CAS
Google Scholar
Mattei S, Schur FK, Briggs JA. Retrovirus maturation—an extraordinary structural transformation. Curr Opin Virol. 2016;18:27–35.
Article
CAS
PubMed
Google Scholar
Pornillos O, Ganser-Pornillos BK. Maturation of retroviruses. Curr Opin Virol. 2019;36:47–55.
Article
CAS
PubMed
PubMed Central
Google Scholar
von Schwedler UK, Stemmler TL, Klishko VY, Li S, Albertine KH, Davis DR, Sundquist WI. Proteolytic refolding of the HIV-1 capsid protein amino-terminus facilitates viral core assembly. EMBO J. 1998;17:1555–68.
Article
Google Scholar
Tang S, Murakami T, Agresta BE, Campbell S, Freed EO, Levin JG. Human immunodeficiency virus type 1 N-terminal capsid mutants that exhibit aberrant core morphology and are blocked in initiation of reverse transcription in infected cells. J Virol. 2001;75:9357–66.
Article
CAS
PubMed
PubMed Central
Google Scholar
Scholz I, Arvidson B, Huseby D, Barklis E. Virus particle core defects caused by mutations in the human immunodeficiency virus capsid N-terminal domain. J Virol. 2005;79:1470–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Yufenyuy EL, Aiken C. The NTD-CTD intersubunit interface plays a critical role in assembly and stabilization of the HIV-1 capsid. Retrovirology. 2013;10:29.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zhao G, Perilla JR, Yufenyuy EL, Meng X, Chen B, Ning J, Ahn J, Gronenborn AM, Schulten K, Aiken C, Zhang P. Mature HIV-1 capsid structure by cryo-electron microscopy and all-atom molecular dynamics. Nature. 2013;497:643–6.
Article
CAS
PubMed
PubMed Central
Google Scholar
Craveur P, Gres AT, Kirby KA, Liu D, Hammond JA, Deng Y, Forli S, Goodsell DS, Williamson JR, Sarafianos SG, Olson AJ. Novel intersubunit interaction critical for HIV-1 core assembly defines a potentially targetable inhibitor binding pocket. mBio. 2019;10.
Brun S, Solignat M, Gay B, Bernard E, Chaloin L, Fenard D, Devaux C, Chazal N, Briant L. VSV-G pseudotyping rescues HIV-1 CA mutations that impair core assembly or stability. Retrovirology. 2008;5:57.
Article
PubMed
PubMed Central
CAS
Google Scholar
Cairns TM, Craven RC. Viral DNA synthesis defects in assembly-competent Rous sarcoma virus CA mutants. J Virol. 2001;75:242–50.
Article
CAS
PubMed
PubMed Central
Google Scholar
Forshey BM, von Schwedler U, Sundquist WI, Aiken C. Formation of a human immunodeficiency virus type 1 core of optimal stability is crucial for viral replication. J Virol. 2002;76:5667–77.
Article
CAS
PubMed
PubMed Central
Google Scholar
Tang S, Murakami T, Cheng N, Steven AC, Freed EO, Levin JG. Human immunodeficiency virus type 1 N-terminal capsid mutants containing cores with abnormally high levels of capsid protein and virtually no reverse transcriptase. J Virol. 2003;77:12592–602.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wacharapornin P, Lauhakirti D, Auewarakul P. The effect of capsid mutations on HIV-1 uncoating. Virology. 2007;358:48–54.
Article
CAS
PubMed
Google Scholar
Jiang J, Ablan SD, Derebail S, Hercík K, Soheilian F, Thomas JA, Tang S, Hewlett I, Nagashima K, Gorelick RJ, et al. The interdomain linker region of HIV-1 capsid protein is a critical determinant of proper core assembly and stability. Virology. 2011;421:253–65.
Article
CAS
PubMed
Google Scholar
Inagaki N, Takeuchi H, Yokoyama M, Sato H, Ryo A, Yamamoto H, Kawada M, Matano T. A structural constraint for functional interaction between N-terminal and C-terminal domains in simian immunodeficiency virus capsid proteins. Retrovirology. 2010;7:90.
Article
PubMed
PubMed Central
CAS
Google Scholar
Francis AC, Marin M, Shi J, Aiken C, Melikyan GB. Time-resolved imaging of single HIV-1 uncoating in vitro and in living cells. PLoS Pathog. 2016;12:e1005709.
Article
PubMed
PubMed Central
CAS
Google Scholar
Márquez CL, Lau D, Walsh J, Shah V, McGuinness C, Wong A, Aggarwal A, Parker MW, Jacques DA, Turville S, Böcking T. Kinetics of HIV-1 capsid uncoating revealed by single-molecule analysis. eLife. 2018;7.
Xu C, Fischer DK, Rankovic S, Li W, Dick RA, Runge B, Zadorozhnyi R, Ahn J, Aiken C, Polenova T, et al. Permeability of the HIV-1 capsid to metabolites modulates viral DNA synthesis. PLoS Biol. 2020;18:e3001015.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hulme AE, Perez O, Hope TJ. Complementary assays reveal a relationship between HIV-1 uncoating and reverse transcription. Proc Natl Acad Sci USA. 2011;108:9975–80.
Article
CAS
PubMed
PubMed Central
Google Scholar
Burdick RC, Hu W-S, Pathak VK. Nuclear import of APOBEC3F-labeled HIV-1 preintegration complexes. Proc Natl Acad Sci USA. 2013;110:E4780-4789.
Article
CAS
PubMed
PubMed Central
Google Scholar
Xu H, Franks T, Gibson G, Huber K, Rahm N, Strambio De Castillia C, Luban J, Aiken C, Watkins S, Sluis-Cremer N, Ambrose Z. Evidence for biphasic uncoating during HIV-1 infection from a novel imaging assay. Retrovirology. 2013;10:70.
Article
PubMed
PubMed Central
Google Scholar
Peng K, Muranyi W, Glass B, Laketa V, Yant SR, Tsai L, Cihlar T, Müller B, Kräusslich H-G. Quantitative microscopy of functional HIV post-entry complexes reveals association of replication with the viral capsid. Elife. 2014;3:e04114.
Article
PubMed
PubMed Central
Google Scholar
Mamede JI, Cianci GC, Anderson MR, Hope TJ. Early cytoplasmic uncoating is associated with infectivity of HIV-1. Proc Natl Acad Sci USA. 2017;114:E7169–78.
Article
CAS
PubMed
PubMed Central
Google Scholar
Francis AC, Melikyan GB. Live-cell imaging of early steps of single HIV-1 infection. Viruses. 2018;10:275.
Article
PubMed Central
CAS
Google Scholar
Stremlau M, Perron M, Lee M, Li Y, Song B, Javanbakht H, Diaz-Griffero F, Anderson DJ, Sundquist WI, Sodroski J. Specific recognition and accelerated uncoating of retroviral capsids by the TRIM5alpha restriction factor. Proc Natl Acad Sci USA. 2006;103:5514–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kutluay SB, Perez-Caballero D, Bieniasz PD. Fates of retroviral core components during unrestricted and TRIM5-restricted infection. PLoS Pathog. 2013;9:e1003214.
Article
CAS
PubMed
PubMed Central
Google Scholar
Yang Y, Luban J, Diaz-Griffero F. The fate of HIV-1 capsid: a biochemical assay for HIV-1 uncoating. Methods Mol Biol. 2014;1087:29–36.
Article
CAS
PubMed
PubMed Central
Google Scholar
Shi J, Aiken C. Saturation of TRIM5 alpha-mediated restriction of HIV-1 infection depends on the stability of the incoming viral capsid. Virology. 2006;350:493–500.
Article
CAS
PubMed
Google Scholar
Hulme AE, Hope TJ. The cyclosporin A washout assay to detect HIV-1 uncoating in infected cells. Methods Mol Biol. 2014;1087:37–46.
Article
CAS
PubMed
PubMed Central
Google Scholar
Jun S, Ke D, Debiec K, Zhao G, Meng X, Ambrose Z, Gibson GA, Watkins SC, Zhang P. Direct visualization of HIV-1 with correlative live-cell microscopy and cryo-electron tomography. Structure (London, England: 1993). 2011;19:1573–81.
Article
CAS
Google Scholar
Hulme AE, Kelley Z, Okocha EA, Hope TJ. Identification of capsid mutations that alter the rate of HIV-1 uncoating in infected cells. J Virol. 2015;89:643–51.
Article
PubMed
CAS
Google Scholar
Da Silva SC, Tartour K, Cimarelli A. A novel entry/uncoating assay reveals the presence of at least two species of viral capsids during synchronized HIV-1 infection. PLoS Pathog. 2016;12:e1005897.
Article
CAS
Google Scholar
Francis AC, Melikyan GB. Single HIV-1 imaging reveals progression of infection through CA-dependent steps of docking at the nuclear pore, uncoating, and nuclear transport. Cell Host Microbe. 2018;23:536-548.e536.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ingram Z, Taylor M, Okland G, Martin R, Hulme AE. Characterization of HIV-1 uncoating in human microglial cell lines. Virol J. 2020;17:31.
Article
CAS
PubMed
PubMed Central
Google Scholar
Eschbach JE, Elliott JL, Li W, Zadrozny KK, Davis K, Mohammed SJ, Lawson DQ, Pornillos O, Engelman AN, Kutluay SB. Capsid lattice destabilization leads to premature loss of the viral genome and integrase enzyme during HIV-1 infection. J Virol. 2020;95.
Forshey BM, Shi J, Aiken C. Structural requirements for recognition of the human immunodeficiency virus type 1 core during host restriction in owl monkey cells. J Virol. 2005;79:869–75.
Article
CAS
PubMed
PubMed Central
Google Scholar
Cosnefroy O, Murray PJ, Bishop KN. HIV-1 capsid uncoating initiates after the first strand transfer of reverse transcription. Retrovirology. 2016;13:58.
Article
PubMed
PubMed Central
CAS
Google Scholar
Dismuke DJ, Aiken C. Evidence for a functional link between uncoating of the human immunodeficiency virus type 1 core and nuclear import of the viral preintegration complex. J Virol. 2006;80:3712–20.
Article
CAS
PubMed
PubMed Central
Google Scholar
Yamashita M, Perez O, Hope TJ, Emerman M. Evidence for direct involvement of the capsid protein in HIV infection of nondividing cells. PLoS Pathog. 2007;3:1502–10.
Article
CAS
PubMed
Google Scholar
Siddiqui MA, Saito A, Halambage UD, Ferhadian D, Fischer DK, Francis AC, Melikyan GB, Ambrose Z, Aiken C, Yamashita M. A novel phenotype links HIV-1 capsid stability to cGAS-mediated DNA sensing. J Virol. 2019;93.
Leschonsky B, Ludwig C, Bieler K, Wagner R. Capsid stability and replication of human immunodeficiency virus type 1 are influenced critically by charge and size of Gag residue 183. J Gen Virol. 2007;88:207–16.
Article
CAS
PubMed
Google Scholar
Burdick RC, Delviks-Frankenberry KA, Chen J, Janaka SK, Sastri J, Hu W-S, Pathak VK. Dynamics and regulation of nuclear import and nuclear movements of HIV-1 complexes. PLoS Pathog. 2017;13:e1006570.
Article
PubMed
PubMed Central
CAS
Google Scholar
Lee K, Ambrose Z, Martin TD, Oztop I, Mulky A, Julias JG, Vandegraaff N, Baumann JG, Wang R, Yuen W, et al. Flexible use of nuclear import pathways by HIV-1. Cell Host Microbe. 2010;7:221–33.
Article
CAS
PubMed
PubMed Central
Google Scholar
Matreyek KA, Engelman A. The requirement for nucleoporin NUP153 during human immunodeficiency virus type 1 infection is determined by the viral capsid. J Virol. 2011;85:7818–27.
Article
CAS
PubMed
PubMed Central
Google Scholar
Matreyek KA, Yücel SS, Li X, Engelman A. Nucleoporin NUP153 phenylalanine-glycine motifs engage a common binding pocket within the HIV-1 capsid protein to mediate lentiviral infectivity. PLoS Pathog. 2013;9:e1003693.
Article
PubMed
PubMed Central
CAS
Google Scholar
Mallery DL, Márquez CL, McEwan WA, Dickson CF, Jacques DA, Anandapadamanaban M, Bichel K, Towers GJ, Saiardi A, Böcking T, James LC. IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis. eLife. 2018;7.
Christensen DE, Ganser-Pornillos BK, Johnson JS, Pornillos O, Sundquist WI. Reconstitution and visualization of HIV-1 capsid-dependent replication and integration in vitro. Science (New York, NY) 2020;370.
Jennings J, Shi J, Varadarajan J, Jamieson PJ, Aiken C. The host cell metabolite inositol hexakisphosphate promotes efficient endogenous HIV-1 reverse transcription by stabilizing the viral capsid. mBio. 2020;11.
Renner N, Mallery DL, Faysal KMR, Peng W, Jacques DA, Böcking T, James LC. A lysine ring in HIV capsid pores coordinates IP6 to drive mature capsid assembly. PLoS Pathog. 2021;17:e1009164.
Article
CAS
PubMed
PubMed Central
Google Scholar
Malikov V, da Silva ES, Jovasevic V, Bennett G, de Souza Aranha Vieira DA, Schulte B, Diaz-Griffero F, Walsh D, Naghavi MH. HIV-1 capsids bind and exploit the kinesin-1 adaptor FEZ1 for inward movement to the nucleus. Nat Commun. 2015;6:6660.
Article
CAS
PubMed
Google Scholar
Huang PT, Summers BJ, Xu C, Perilla JR, Malikov V, Naghavi MH, Xiong Y. FEZ1 is recruited to a conserved cofactor site on capsid to promote HIV-1 trafficking. Cell Rep. 2019;28:2373-2385e2377.
Article
CAS
PubMed
PubMed Central
Google Scholar
Jacques DA, McEwan WA, Hilditch L, Price AJ, Towers GJ, James LC. HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis. Nature. 2016;536:349–53.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ganser-Pornillos BK, von Schwedler UK, Stray KM, Aiken C, Sundquist WI. Assembly properties of the human immunodeficiency virus type 1 CA protein. J Virol. 2004;78:2545–52.
Article
CAS
PubMed
PubMed Central
Google Scholar
Luban J, Bossolt KL, Franke EK, Kalpana GV, Goff SP. Human immunodeficiency virus type 1 Gag protein binds to cyclophilins A and B. Cell. 1993;73:1067–78.
Article
CAS
PubMed
Google Scholar
Schaller T, Ocwieja KE, Rasaiyaah J, Price AJ, Brady TL, Roth SL, Hué S, Fletcher AJ, Lee K, Kewal Ramani VN, et al. HIV-1 capsid-cyclophilin interactions determine nuclear import pathway, integration targeting and replication efficiency. PLoS Pathog. 2011;7:e1002439.
Article
CAS
PubMed
PubMed Central
Google Scholar
Di Nunzio F, Danckaert A, Fricke T, Perez P, Fernandez J, Perret E, Roux P, Shorte S, Charneau P, Diaz-Griffero F, Arhel NJ. Human nucleoporins promote HIV-1 docking at the nuclear pore, nuclear import and integration. PLoS ONE. 2012;7:e46037.
Article
PubMed
PubMed Central
CAS
Google Scholar
Li Y, Kar AK, Sodroski J. Target cell type-dependent modulation of human immunodeficiency virus type 1 capsid disassembly by cyclophilin A. J Virol. 2009;83:10951–62.
Article
CAS
PubMed
PubMed Central
Google Scholar
Tipper C, Sodroski JG. Contribution of glutamine residues in the helix 4–5 loop to capsid–capsid interactions in simian immunodeficiency virus of macaques. J Virol. 2014;88:10289–302.
Article
PubMed
PubMed Central
CAS
Google Scholar
Gamble TR, Vajdos FF, Yoo S, Worthylake DK, Houseweart M, Sundquist WI, Hill CP. Crystal structure of human cyclophilin A bound to the amino-terminal domain of HIV-1 capsid. Cell. 1996;87:1285–94.
Article
CAS
PubMed
Google Scholar
Franke EK, Yuan HE, Luban J. Specific incorporation of cyclophilin A into HIV-1 virions. Nature. 1994;372:359–62.
Article
CAS
PubMed
Google Scholar
Braaten D, Franke EK, Luban J. Cyclophilin A is required for an early step in the life cycle of human immunodeficiency virus type 1 before the initiation of reverse transcription. J Virol. 1996;70:3551–60.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bukovsky AA, Weimann A, Accola MA, Göttlinger HG. Transfer of the HIV-1 cyclophilin-binding site to simian immunodeficiency virus from Macaca mulatta can confer both cyclosporin sensitivity and cyclosporin dependence. Proc Natl Acad Sci USA. 1997;94:10943–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Yoo S, Myszka DG, Yeh C, McMurray M, Hill CP, Sundquist WI. Molecular recognition in the HIV-1 capsid/cyclophilin A complex. J Mol Biol. 1997;269:780–95.
Article
CAS
PubMed
Google Scholar
Yin L, Braaten D, Luban J. Human immunodeficiency virus type 1 replication is modulated by host cyclophilin A expression levels. J Virol. 1998;72:6430–6.
Article
CAS
PubMed
PubMed Central
Google Scholar
Braaten D, Luban J. Cyclophilin A regulates HIV-1 infectivity, as demonstrated by gene targeting in human T cells. EMBO J. 2001;20:1300–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Petrillo C, Cesana D, Piras F, Bartolaccini S, Naldini L, Montini E, Kajaste-Rudnitski A. Cyclosporin a and rapamycin relieve distinct lentiviral restriction blocks in hematopoietic stem and progenitor cells. Mol Ther J Am Soc Gene Ther. 2015;23:352–62.
Article
CAS
Google Scholar
Barateau V, Nguyen X-N, Bourguillault F, Berger G, Cordeil S, Cimarelli A. The susceptibility of primate lentiviruses to nucleosides and Vpx during infection of dendritic cells is regulated by CA. J Virol. 2015;89:4030–4.
Article
CAS
PubMed
PubMed Central
Google Scholar
Selyutina A, Persaud M, Simons LM, Bulnes-Ramos A, Buffone C, Martinez-Lopez A, Scoca V, Di Nunzio F, Hiatt J, Marson A, et al. Cyclophilin A prevents HIV-1 restriction in lymphocytes by blocking human TRIM5α binding to the viral core. Cell Rep. 2020;30:3766-3777.e3766.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ackerson B, Rey O, Canon J, Krogstad P. Cells with high cyclophilin A content support replication of human immunodeficiency virus type 1 Gag mutants with decreased ability to incorporate cyclophilin A. J Virol. 1998;72:303–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kim K, Dauphin A, Komurlu S, McCauley SM, Yurkovetskiy L, Carbone C, Diehl WE, Strambio-De-Castillia C, Campbell EM, Luban J. Cyclophilin A protects HIV-1 from restriction by human TRIM5α. Nat Microbiol. 2019;4:2044–51.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zhong Z, Ning J, Boggs EA, Jang S, Wallace C, Telmer C, Bruchez MP, Ahn J, Engelman AN, Zhang P, et al. Cytoplasmic CPSF6 regulates HIV-1 capsid trafficking and infection in a cyclophilin A-dependent manner. mBio. 2021;12.
Engelman AN. HIV capsid and integration targeting. Viruses. 2021;13:125.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hilditch L, Towers GJ. A model for cofactor use during HIV-1 reverse transcription and nuclear entry. Curr Opin Virol. 2014;4:32–6.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kane M, Rebensburg SV, Takata MA, Zang TM, Yamashita M, Kvaratskhelia M, Bieniasz PD. Nuclear pore heterogeneity influences HIV-1 infection and the antiviral activity of MX2. eLife. 2018;7.
Dharan A, Talley S, Tripathi A, Mamede JI, Majetschak M, Hope TJ, Campbell EM. KIF5B and Nup358 cooperatively mediate the nuclear import of HIV-1 during infection. PLoS Pathog. 2016;12:e1005700.
Article
PubMed
PubMed Central
CAS
Google Scholar
Meehan AM, Saenz DT, Guevera R, Morrison JH, Peretz M, Fadel HJ, Hamada M, van Deursen J, Poeschla EM. A cyclophilin homology domain-independent role for Nup358 in HIV-1 infection. PLoS Pathog. 2014;10:e1003969.
Article
PubMed
PubMed Central
CAS
Google Scholar
Fernandez J, Machado AK, Lyonnais S, Chamontin C, Gärtner K, Léger T, Henriquet C, Garcia C, Portilho DM, Pugnière M, et al. Transportin-1 binds to the HIV-1 capsid via a nuclear localization signal and triggers uncoating. Nat Microbiol. 2019;4:1840–50.
Article
CAS
PubMed
Google Scholar
Luo X, Yang W, Gao G. SUN1 regulates HIV-1 nuclear import in a manner dependent on the interaction between the viral capsid and cellular cyclophilin A. J Virol. 2018;92.
Lahaye X, Satoh T, Gentili M, Cerboni S, Silvin A, Conrad C, Ahmed-Belkacem A, Rodriguez EC, Guichou J-F, Bosquet N, et al. Nuclear envelope protein SUN2 promotes cyclophilin-A-dependent steps of HIV replication. Cell Rep. 2016;15:879–92.
Article
CAS
PubMed
PubMed Central
Google Scholar
Dutrieux J, Maarifi G, Portilho DM, Arhel NJ, Chelbi-Alix MK, Nisole S. PML/TRIM19-dependent inhibition of retroviral reverse-transcription by Daxx. PLoS Pathog. 2015;11:e1005280.
Article
PubMed
PubMed Central
CAS
Google Scholar
Maillet S, Fernandez J, Decourcelle M, El Koulali K, Blanchet FP, Arhel NJ, Maarifi G, Nisole S. Daxx inhibits HIV-1 reverse transcription and uncoating in a SUMO-dependent manner. Viruses. 2020;12:636.
Article
CAS
PubMed Central
Google Scholar
Lahaye X, Satoh T, Gentili M, Cerboni S, Conrad C, Hurbain I, El Marjou A, Lacabaratz C, Lelièvre J-D, Manel N. The capsids of HIV-1 and HIV-2 determine immune detection of the viral cDNA by the innate sensor cGAS in dendritic cells. Immunity. 2013;39:1132–42.
Article
CAS
PubMed
Google Scholar
Rasaiyaah J, Tan CP, Fletcher AJ, Price AJ, Blondeau C, Hilditch L, Jacques DA, Selwood DL, James LC, Noursadeghi M, Towers GJ. HIV-1 evades innate immune recognition through specific cofactor recruitment. Nature. 2013;503:402–5.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wei W, Guo H, Ma M, Markham R, Yu X-F. Accumulation of MxB/Mx2-resistant HIV-1 capsid variants during expansion of the HIV-1 epidemic in human populations. EBioMedicine. 2016;8:230–6.
Article
PubMed
PubMed Central
Google Scholar
Setiawan LC, van Dort KA, Rits MAN, Kootstra NA. Mutations in CypA binding region of HIV-1 capsid affect capsid stability and viral replication in primary macrophages. AIDS Res Hum Retroviruses. 2016;32:390–8.
Article
CAS
PubMed
Google Scholar
Saha B, Chisholm D, Kell AM, Mandell MA. A non-canonical role for the autophagy machinery in anti-retroviral signaling mediated by TRIM5alpha. PLoS Pathog. 2020;16:e1009017.
Article
CAS
PubMed
PubMed Central
Google Scholar
Manel N, Hogstad B, Wang Y, Levy DE, Unutmaz D, Littman DR. A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells. Nature. 2010;467:214–7.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bulli L, Apolonia L, Kutzner J, Pollpeter D, Goujon C, Herold N, Schwarz S-M, Giernat Y, Keppler OT, Malim MH, Schaller T. Complex interplay between HIV-1 capsid and MX2-independent alpha interferon-induced antiviral factors. J Virol. 2016;90:7469–80.
Article
CAS
PubMed
PubMed Central
Google Scholar
Sultana T, Mamede JI, Saito A, Ode H, Nohata K, Cohen R, Nakayama EE, Iwatani Y, Yamashita M, Hope TJ, Shioda T. Multiple pathways to avoid beta interferon sensitivity of HIV-1 by mutations in capsid. J Virol. 2019;93.
Aberham C, Weber S, Phares W. Spontaneous mutations in the human immunodeficiency virus type 1 gag gene that affect viral replication in the presence of cyclosporins. J Virol. 1996;70:3536–44.
Article
CAS
PubMed
PubMed Central
Google Scholar
Qi M, Yang R, Aiken C. Cyclophilin A-dependent restriction of human immunodeficiency virus type 1 capsid mutants for infection of nondividing cells. J Virol. 2008;82:12001–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Yamashita M, Emerman M. Cellular restriction targeting viral capsids perturbs human immunodeficiency virus type 1 infection of nondividing cells. J Virol. 2009;83:9835–43.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ylinen LMJ, Schaller T, Price A, Fletcher AJ, Noursadeghi M, James LC, Towers GJ. Cyclophilin A levels dictate infection efficiency of human immunodeficiency virus type 1 capsid escape mutants A92E and G94D. J Virol. 2009;83:2044–7.
Article
CAS
PubMed
Google Scholar
Yang R, Aiken C. A mutation in alpha helix 3 of CA renders human immunodeficiency virus type 1 cyclosporin A resistant and dependent: rescue by a second-site substitution in a distal region of CA. J Virol. 2007;81:3749–56.
Article
CAS
PubMed
PubMed Central
Google Scholar
Takemura T, Kawamata M, Urabe M, Murakami T. Cyclophilin A-dependent restriction to capsid N121K mutant human immunodeficiency virus type 1 in a broad range of cell lines. J Virol. 2013;87:4086–90.
Article
CAS
PubMed
PubMed Central
Google Scholar
Schneidewind A, Brockman MA, Yang R, Adam RI, Li B, Le Gall S, Rinaldo CR, Craggs SL, Allgaier RL, Power KA, et al. Escape from the dominant HLA-B27-restricted cytotoxic T-lymphocyte response in Gag is associated with a dramatic reduction in human immunodeficiency virus type 1 replication. J Virol. 2007;81:12382–93.
Article
CAS
PubMed
PubMed Central
Google Scholar
Matsuoka S, Dam E, Lecossier D, Clavel F, Hance AJ. Modulation of HIV-1 infectivity and cyclophilin A-dependence by Gag sequence and target cell type. Retrovirology. 2009;6:21.
Article
PubMed
PubMed Central
CAS
Google Scholar
Battivelli E, Lecossier D, Matsuoka S, Migraine J, Clavel F, Hance AJ. Strain-specific differences in the impact of human TRIM5alpha, different TRIM5alpha alleles, and the inhibition of capsid-cyclophilin A interactions on the infectivity of HIV-1. J Virol. 2010;84:11010–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Henning MS, Dubose BN, Burse MJ, Aiken C, Yamashita M. In vivo functions of CPSF6 for HIV-1 as revealed by HIV-1 capsid evolution in HLA-B27-positive subjects. PLoS Pathog. 2014;10:e1003868.
Article
PubMed
PubMed Central
CAS
Google Scholar
Sokolskaja E, Sayah DM, Luban J. Target cell cyclophilin A modulates human immunodeficiency virus type 1 infectivity. J Virol. 2004;78:12800–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hatziioannou T, Perez-Caballero D, Cowan S, Bieniasz PD. Cyclophilin interactions with incoming human immunodeficiency virus type 1 capsids with opposing effects on infectivity in human cells. J Virol. 2005;79:176–83.
Article
CAS
PubMed
PubMed Central
Google Scholar
Song C, Aiken C. Analysis of human cell heterokaryons demonstrates that target cell restriction of cyclosporine-resistant human immunodeficiency virus type 1 mutants is genetically dominant. J Virol. 2007;81:11946–56.
Article
CAS
PubMed
PubMed Central
Google Scholar
De Iaco A, Luban J. Cyclophilin A promotes HIV-1 reverse transcription but its effect on transduction correlates best with its effect on nuclear entry of viral cDNA. Retrovirology. 2014;11:11.
Article
PubMed
PubMed Central
CAS
Google Scholar
Sokolskaja E, Berthoux L, Luban J. Cyclophilin A and TRIM5alpha independently regulate human immunodeficiency virus type 1 infectivity in human cells. J Virol. 2006;80:2855–62.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zhang F, Hatziioannou T, Perez-Caballero D, Derse D, Bieniasz PD. Antiretroviral potential of human tripartite motif-5 and related proteins. Virology. 2006;353:396–409.
Article
CAS
PubMed
Google Scholar
Kane M, Yadav SS, Bitzegeio J, Kutluay SB, Zang T, Wilson SJ, Schoggins JW, Rice CM, Yamashita M, Hatziioannou T, Bieniasz PD. MX2 is an interferon-induced inhibitor of HIV-1 infection. Nature. 2013;502:563–6.
Article
CAS
PubMed
PubMed Central
Google Scholar
Matreyek KA, Wang W, Serrao E, Singh PK, Levin HL, Engelman A. Host and viral determinants for MxB restriction of HIV-1 infection. Retrovirology. 2014;11:90.
Article
PubMed
PubMed Central
CAS
Google Scholar
De Iaco A, Luban J. Inhibition of HIV-1 infection by TNPO3 depletion is determined by capsid and detectable after viral cDNA enters the nucleus. Retrovirology. 2011;8:98.
Article
PubMed
PubMed Central
CAS
Google Scholar
Ambrose Z, Lee K, Ndjomou J, Xu H, Oztop I, Matous J, Takemura T, Unutmaz D, Engelman A, Hughes SH, KewalRamani VN. Human immunodeficiency virus type 1 capsid mutation N74D alters cyclophilin A dependence and impairs macrophage infection. J Virol. 2012;86:4708–14.
Article
CAS
PubMed
PubMed Central
Google Scholar
Shah VB, Aiken C. Gene expression analysis of a panel of cell lines that differentially restrict HIV-1 CA mutants infection in a cyclophilin a-dependent manner. PLoS ONE. 2014;9:e92724.
Article
PubMed
PubMed Central
CAS
Google Scholar
Kootstra NA, Navis M, Beugeling C, van Dort KA, Schuitemaker H. The presence of the Trim5alpha escape mutation H87Q in the capsid of late stage HIV-1 variants is preceded by a prolonged asymptomatic infection phase. AIDS (London, England). 2007;21:2015–23.
Article
CAS
Google Scholar
Brockman MA, Schneidewind A, Lahaie M, Schmidt A, Miura T, Desouza I, Ryvkin F, Derdeyn CA, Allen S, Hunter E, et al. Escape and compensation from early HLA-B57-mediated cytotoxic T-lymphocyte pressure on human immunodeficiency virus type 1 Gag alter capsid interactions with cyclophilin A. J Virol. 2007;81:12608–18.
Article
CAS
PubMed
PubMed Central