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Table 2 Capsid-dependent cellular proteins

From: HIV-1 capsid variability: viral exploitation and evasion of capsid-binding molecules

Gene name

Gene ID

Also known as

Gene description

Strategy for gene discovery

References

CPSF6

11052

Cleavage and polyadenylation specific factor 6

Subunit of a cleavage factor required for 3′ RNA cleavage and polyadenylation processing

Expression cloning

[93]

Cyclophilin A

5478

PPIA

Member of the peptidyl-prolyl cis–trans isomerase (PPIase) family

GAL4 two-hybrid screen

[104]

FEZ1

9638

Fasciculat ion and elongation protein zeta 1

Ortholog of the Caenorhabditis elegans unc-76 gene that is necessary for axonal bundling and elongation within axon bundles

RNAi-mediated inhibition

[100]

KIF5B

3799

Kinesin family member 5b

Member of the kinesin family protein with ATPase that acts as a microtubule motor

Pharmacological and RNAi-mediated inhibition

[125]

MX2

4600

MXB, MX dynamin like GTPase

Member of both the dynamin family and the family of large GTPases

Transcriptional profiling

[156, 292, 293]

NUP153

9972

Nucleoporin 153

Nucleoporin carrying characteristic XFXFG pentapeptides

Large-scale RNAi screening

[356, 357]

NUP358

5903

RANBP2

A large RAN-binding protein that localizes to the nuclear pore complex

Large-scale RNAi screening

[356, 357]

SUN2

25777

Sad1 and unc84 domain containing 2

An inner nuclear membrane protein with a major role in nuclear-cytoplasmic connection

Sun2-null mouse cells

[129, 358]

TNPO3

23534

Transportin (TRN) 3/TRN-SR2

Nuclear transport receptor for serine/arginine-rich proteins

Yeast-two-hybrid and siRNA screens

[356, 357, 359]

TRIM5α

85363

Tripartite motif containing 5α

Member of the tripartite motif (TRIM) family

Expression cloning

[230]

TRIM34

53840

Tripartite motif containing 34

Member of the TRIM family

HIV-CRISPR screening

[290]