Volume 11 Supplement 1

16th International Conference on Human Retroviruses: HTLV and Related Viruses

Meeting abstracts

Edited by Benoit Barbeau

Publication of this supplement was funded by the Canadian Institutes of Health Research (#201206). The Supplement Editor declares that he has no competing interests.

16th International Conference on Human Retroviruses: HTLV and Related Viruses. Go to conference site.

Montreal, Canada26-30 June 2013

Page 2 of 5

Estimation of clonal diversity in HTLV-1 infection

Authors: Daniel J Laydon, Anat Melamed, Aaron Sim, Nicolas A Gillet, Kathleen Sim, Sam Darko, J Simon Kroll, Daniel C Douek, David A Price, Charles RM Bangham and Becca Asquith

Citation: Retrovirology 2014 11(Suppl 1):O50

Content type: Oral presentation Published on: 7 January 2014
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Molecular mechanisms of apoptosis suppression by HTLV-1 bZIP factor in HTLV-1 infected cells

Authors: Azusa Tanaka-Nakanishi, Jun-ichirou Yasunaga, Ken Takai and Masao Matsuoka

Citation: Retrovirology 2014 11(Suppl 1):O51

Content type: Oral presentation Published on: 7 January 2014
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Stress granules inhibit apoptosis by reducing ROS production, but this phenomenon is nullified by HTLV-1 Tax

Authors: Masahiko Takahashi, Masaya Higuchi and Masahiro Fujii

Citation: Retrovirology 2014 11(Suppl 1):O52

Content type: Oral presentation Published on: 7 January 2014
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Biochemical analysis of the diverse functions of the HTLV-1-encoded oncoprotein Tax

Authors: Jennifer K Nyborg, Dinaida Egan and Neelam Sharma

Citation: Retrovirology 2014 11(Suppl 1):O53

Content type: Oral presentation Published on: 7 January 2014
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Molecular hallmarks of adult T cell leukemia: miRNA, epigenetics, and emerging signaling abnormalities

Authors: Makoto Yamagishi, Dai Fujikawa, Naoya Kurokawa, Ai Soejima, Ryutaro Takahashi, Naoki Sakai, Shota Nakagawa, Kazumi Nakano, Seiichiro Kobayashi, Atae Utsunomiya, Kazunari Yamaguchi, Kaoru Uchimaru, Seishi Ogawa and Toshiki Watanabe

Citation: Retrovirology 2014 11(Suppl 1):O54

Content type: Oral presentation Published on: 7 January 2014
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Deregulation of RNAi silencing pathway by Human T-cell leukemia virus type 1 bZIP factor (HBZ)

Authors: Hélène Gazon, Jean-Michel Mesnard, Raymond Césaire and Jean-Marie Peloponese Jr

Citation: Retrovirology 2014 11(Suppl 1):O55

Content type: Oral presentation Published on: 7 January 2014
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HBZ RNA may promote cell survival against clastogenic damages and thereby contributes to the development of leukemic ATL cells

Authors: Marco Goicochea, Toshie Nata, Robert Gallo, Hua Cheng and Yutaka Tagaya

Citation: Retrovirology 2014 11(Suppl 1):O56

Content type: Oral presentation Published on: 7 January 2014
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A BDNF/TrKB autocrine loop stimulated by HBZ is involved in HTLV-1-infected cell-survival

Authors: Nicholas Polakowski, Marie Terol, Isabelle Nash, Kimson Hoang, Hélène Gazon, Torsten Wurm, Raymond Césaire, Jean-Marie Péloponèse, Jean-Michel Mesnard and Isabelle Lemasson

Citation: Retrovirology 2014 11(Suppl 1):O57

Content type: Oral presentation Published on: 7 January 2014
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The SUMOylation machinery is dispensable for Tax-induced NF-kB activation

Authors: Sabrina Pène, Amandine Bonnet, Laetitia Waast, Laurence Bénit and Claudine Pique

Citation: Retrovirology 2014 11(Suppl 1):O60

Content type: Oral presentation Published on: 7 January 2014
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Nonsense-mediated mRNA decay inhibition by HTLV-1 Tax protein

Authors: Vincent Mocquet, Julia Neusiedler, Francesca Rende, David Cluet, Jean-Philippe Robin, Jean-Michel Terme, Madeleine Duc-Dodon, Christelle Morris, Hervé Le Hir, Vincenzo Ciminale and Pierre Jalinot

Citation: Retrovirology 2014 11(Suppl 1):O61

Content type: Oral presentation Published on: 7 January 2014
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Elucidating the role of Bovine Leukemia Virus encoded micro-RNAs

Authors: Keith Durkin, Nicolas Rosewick, Mélanie Momont, Wannes Thys, Arsène Burny, Michel Georges and Anne Van den Broeke

Citation: Retrovirology 2014 11(Suppl 1):O62

Content type: Oral presentation Published on: 7 January 2014
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Massive depletion of BLV proviral clones located in genomic transcriptionally active sites during primary infection

Authors: Nicolas A Gillet, Gerónimo Gutiérrez, Alix de Brogniez, Sabrina M Rodriguez, Nathalie Renotte, Irene Alvarez, Lucas Vagnoni, Karina Trono and Luc Willems

Citation: Retrovirology 2014 11(Suppl 1):O63

Content type: Oral presentation Published on: 7 January 2014
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Transcriptomic analyses reveal that the cellular Gem protein promotes HTLV-1 infected cell migration and viral transmission

Authors: Sébastien A Chevalier, Cynthia A Pise-Masison, Antoine Gessain and Renaud Mahieux

Citation: Retrovirology 2014 11(Suppl 1):O64

Content type: Oral presentation Published on: 7 January 2014
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Role of protein arginine methyltransferase 5 over-expression in HTLV-1-driven cellular transformation and leukemia

Authors: Amanda R Panfil, Jacob J Al-Saleem, Robert A Baiocchi and Patrick L Green

Citation: Retrovirology 2014 11(Suppl 1):O65

Content type: Oral presentation Published on: 7 January 2014
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Alternative splicing signatures discriminate ATL cells from untransformed CD4+ counterparts deriving from HTLV-1 infected individuals

Authors: Morgan Thenoz, Céline Vernin, Christiane Pinatel, Nicolas Nazaret, Joel Lachuer, Antoine Gessain, Didier Auboeuf, Eric Wattel and Franck Mortreux

Citation: Retrovirology 2014 11(Suppl 1):O66

Content type: Oral presentation Published on: 7 January 2014
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An altered maturation and adhesion phenotype of dendritic cells in diseased individuals compared to asymptomatic carriers of human T-cell leukemia virus type 1

Authors: Sharrón L Manuel, Mohit Sehgal, Zafar K Khan, James J Goedert, Michael R Betts and Pooja Jain

Citation: Retrovirology 2014 11(Suppl 1):O67

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High resolution lectin microarray system for the ATL cell-typing and the evaluation of anti-cancer efficacy of medications

Authors: Hidekatsu Iha, Emi Ikebe, Takashi Matsumoto, Akira Nishizono, Masao Ogata, Yuetsu Tanaka, Mitsuo Hori, Eisaburo Sueoka, Jun-ichi Fujisawa and Kazuhiro Morishita

Citation: Retrovirology 2014 11(Suppl 1):O68

Content type: Oral presentation Published on: 7 January 2014
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Characterization of glycans of CD4+T cells in HAM/TSP

Authors: Daisuke Kodama, Kimiko Izumo, Ryuji Kubota, Toshio Matsuzaki, Hiroshi Takashima and Shuji Izumo

Citation: Retrovirology 2014 11(Suppl 1):O69

Content type: Oral presentation Published on: 7 January 2014
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Characterization of a human betaretrovirus in patients with primary biliary cirrhosis

Authors: Weiwei Wang, Stan Indik, Shawn T Wasilenko, Gane K-S Wong and Andrew L Mason

Citation: Retrovirology 2014 11(Suppl 1):O70

Content type: Oral presentation Published on: 7 January 2014
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Latency, tropism and genetic variation of Simian Foamy Virus in blood and saliva from infected Humans

Authors: Réjane Rua, Edouard Betsem, Thomas Montange, Florence Buseyne and Antoine Gessain

Citation: Retrovirology 2014 11(Suppl 1):O71

Content type: Oral presentation Published on: 7 January 2014
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HTLV-3 and HTLV-4 antisense proteins enhance the transactivation potential of several Jun family members through interaction via their bZIP-like domain

Authors: Émilie Larocque, Charlotte André-Arpin, Jean-Michel Mesnard, William M Switzer and Benoit Barbeau

Citation: Retrovirology 2014 11(Suppl 1):O72

Content type: Oral presentation Published on: 7 January 2014
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Localization and sub-cellular shuttling of HTLV-1 Tax with the microRNA machinery

Authors: Rachel Van Duyne, Irene Guendel, Aarthi Narayanan, Kylene Kehn-Hall, Elizabeth Jaworski, Jessica Roman, William Coley, Zachary Klase, Anastas Popratiloff, Renaud Mahieux and Fatah Kashanchi

Citation: Retrovirology 2014 11(Suppl 1):O73

Content type: Oral presentation Published on: 7 January 2014
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The structure and genomic integration site of the HTLV-1 provirus determine selective clonal expansion and transformation to adult T cell leukaemia/lymphoma

Authors: Lucy B Cook, Heather Niederer, Anat Melamed, Graham P Taylor, Masao Matsuoka and Charles RM Bangham

Citation: Retrovirology 2014 11(Suppl 1):O76

Content type: Oral presentation Published on: 7 January 2014
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Different routes of entry of HTLV-1 during infection of primary dendritic cells and CD4+ T cells

Authors: Kathryn S Jones, Cari Petrow-Sadowski, Daniel C Bertolette, Nabela Enam, Rachel K Bagni, Stig MR Jensen, David A Davis, Robert Yarchoan and Francis W Ruscetti

Citation: Retrovirology 2014 11(Suppl 1):O77

Content type: Oral presentation Published on: 7 January 2014
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Adult T-cell leukemia/lymphoma following elevation of serum levels of soluble cytokine receptors, sCD25 and sCD30

Authors: Shigeki Takemoto, Koji Uzawa, Kazuki Morita, Ratiorn Pornkuna, Yoshio Haga, Masako Iwanaga, Yasuko Sagara, Fumio Kawano and Toshiki Watanabe

Citation: Retrovirology 2014 11(Suppl 1):P1

Content type: Poster presentation Published on: 7 January 2014
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Soluble CD30 is a new biomarker to predict two-year overall survival of adult T cell leukemia/lymphoma patients

Authors: Ratiorn Pornkuna, Shigeki Takemoto, Michihiro Hidaka and Yoshio Haga

Citation: Retrovirology 2014 11(Suppl 1):P2

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Clinical manifestations in HTLV-1 infected individuals without HAM/TSP: Results of an 8 years cohort

Authors: Davi Tanajura, Néviton Castro, Paulo Oliveira, Glória Orge, Anselmo Souza, Natália Barbosa, Silvane Santos and Edgar Carvalho

Citation: Retrovirology 2014 11(Suppl 1):P3

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A phase II study of lenalidomide in patients with relapsed or refractory ATLL

Authors: Adrienne A Phillips, Jalanni Giddings and Steven M Horwitz

Citation: Retrovirology 2014 11(Suppl 1):P4

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Sensitive detection and apoptotic cell death induction of adult T-cell leukemia/lymphoma (ATL) cells with photodynamic actions

Authors: Takashi Oka, Hirofumi Fujita, Lamia Abd Al-Kader, Ichiro Murakami, Atae Utsunomiya and Tadashi Yoshino

Citation: Retrovirology 2014 11(Suppl 1):P5

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Prevalence and influence of tuberculosis in the neurologic manifestations of the Human T cell lymphotropic virus type 1 (HTLV-1)

Authors: Maria de Lourdes Bastos, Anselmo Souza, Natália Carvalho, Yuri Neves, Silvane Santos and Edgar M Carvalho

Citation: Retrovirology 2014 11(Suppl 1):P6

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Inflammation with HTLV-1-specific CTLs occurs in the spinal cord of HTLV-1 carriers and the brain of the patients with HAM/TSP

Authors: Eiji Matsuura, Satoshi Nozuma, Toshio Matsuzaki, Osamu Watanabe, Ryuji Kubota, Shuji Izumo and Hiroshi Takashima

Citation: Retrovirology 2014 11(Suppl 1):P7

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Case reports: combination therapy with proteasome inhibitor Bortezomib and humanized anti-CD25 Basiliximab for treatment of adult T cell leukaemia lymphoma

Authors: Huseini Kagdi, Paul Fields, Andrew Hodson and Graham Taylor

Citation: Retrovirology 2014 11(Suppl 1):P8

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The potential of CD127 as a prognostic and residual disease marker in chronic adult T cell leukaemia/lymphoma

Authors: Huseini Kagdi, Anat Melamed, Silva Hilburn, Nicolas Gillet, Andrew Hodson, Maria A Demontis, Aileen Rowan, Lucy Cook, Charles Bangham and Graham Taylor

Citation: Retrovirology 2014 11(Suppl 1):P9

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Amendment on brain signal intensity on Magnetic Resonance Imaging of asymptomatic HTLV-1 seropositive and HTLV-1 associated myelopathy

Authors: Rafael HC Bastos, Luciana C Silva, Débora B Reiss, Gabriela S Freitas, Mariana A Souza, Cláudia LF Horiguchi, João GR Ribas, Aline M Silva, Marina L Martins, Anísia da SD Ferreira, Tatiana Martins, Anna Bárbara FC Proietti and Luiz CF Romanelli

Citation: Retrovirology 2014 11(Suppl 1):P10

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HTLV-1 and bronchiectasis in a UK cohort, report and review

Authors: Shohreh Honarbakhsh and Graham P Taylor

Citation: Retrovirology 2014 11(Suppl 1):P11

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Sensitivity and specificity of spinal cord Magnetic Resonance Imaging in the diagnosis of HTLV-1 associated myelopathy

Authors: Luiz CF Romanelli, Rafael HC Bastos, Luciana C Silva, Tatiana Martins, Débora B Reiss, Gabriela S Freitas, Mariana A Souza, Cláudia LF Horiguchi, João GR Ribas, Aline M Silva, Fernando A Proietti, Marina L Martins, Anísia da SD Ferreira and Anna Bárbara FC Proietti

Citation: Retrovirology 2014 11(Suppl 1):P12

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Digital droplet PCR for precise quantification of human T-lymphotropic virus 1 proviral loads

Authors: Giovanna S Brunetto, Raya Massoud, Joan Ohayon, Kaylan Fenton, Irene Cortese and Steven Jacobson

Citation: Retrovirology 2014 11(Suppl 1):P13

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BNZ-gamma peptide, a potential therapeutic agent in HTLV-1 associated myelopathy

Authors: Raya Massoud, Yoshimi Enose-Akahata, Yutaka Tagaya, Nazli Azimi and Steven Jacobson

Citation: Retrovirology 2014 11(Suppl 1):P14

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Induction of molecular remission by using anti-CC-chemokine receptor 4 (anti-CCR4) antibodies for adult T-cell leukemia: a risk of opportunistic infection after treatment with anti-CCR4 antibodies

Authors: Yasuhiuro Maeda, Go Eguchi, Takahiro Kumode and Terufumi Yamaguchi

Citation: Retrovirology 2014 11(Suppl 1):P15

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Correlation of HTLV-1 proviral load and lymphocyte proliferation from asymptomatic HTLV-1-positive patients and HAM/TSP patients associated or not to skin disorders

Authors: Renata Okajima, Jerusa Smid, Alberto JS Duarte, Augusto Cesar Penalva de Oliveira, Jorge Casseb and José Antonio Sanches Junior

Citation: Retrovirology 2014 11(Suppl 1):P16

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Nation-wide epidemiological study in Japan on HTLV-1 associated myelopathy/tropical spastic paraparesis using HAM-net, a novel patient registration system

Authors: Ariella LG Coler-Reilly, Michiyo Hashimoto, Naoko Yagishita, Tomoo Sato, Hitoshi Ando, Junji Yamauchi, Natsumi Araya, Miyako Kimura, Yoshihisa Yamano and Ayako Takata

Citation: Retrovirology 2014 11(Suppl 1):P17

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CXCL10 and neopterin in CSF are candidate prognostic biomarkers for HTLV-1-associated myelopathy/tropical spastic paraparesis

Authors: Yoshihisa Yamano, Tomoo Sato, Hitoshi Ando, Natsumi Araya, Naoko Yagishita, Junji Yamauchi, Ariella Coler-Reilly, Atae Utsunomiya, Steven Jacobson and Shuji Izumo

Citation: Retrovirology 2014 11(Suppl 1):P18

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The kinetics of HTLV-1 proviral load after allogeneic hematopoietic cell transplantation with reduced intensity conditioning regimen; a comparison with that from sibling donors and that from unrelated donors

Authors: Ilseung Choi, Ryuji Tanosaki, Atae Utsunomiya, Yoko Suehiro, Jun Okamura and Naokuni Uike

Citation: Retrovirology 2014 11(Suppl 1):P19

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Using the 6 minute walk to investigate endurance in patients with HTLV associated myelopathy

Authors: A Adonis and G Taylor

Citation: Retrovirology 2014 11(Suppl 1):P20

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Immunotherapeutic potential of varicella vaccine in smoldering and cutaneous adult T-cell leukemia/lymphoma

Authors: M Amano and M Setoyama

Citation: Retrovirology 2014 11(Suppl 1):P21

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Quantifying spinal cord cross-sectional area in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)

Authors: Winston Liu, Anshika Bakshi, Raya Massoud, Giovanna S Brunetto, Daniel S Reich, Govind Nair and Steven Jacobson

Citation: Retrovirology 2014 11(Suppl 1):P22

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Follow-up of HTLV-1 positive individuals in the GIPH cohort (1997-2013): Proviral load was not a prognostic marker for HAM/TSP

Authors: Poliane C Gonçalves, Gabriela S Freitas, Luiz CF Romanelli, Fernando A Proietti, Anna B Carneiro-Proietti and Marina L Martins

Citation: Retrovirology 2014 11(Suppl 1):P23

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Effect of a novel anti-CCR4 monoclonal antibody (Mogamulizmab) on skin lesions of adult T-cell leukemia-lymphoma (ATL) and its adverse skin reactions (ASR)

Authors: Kentaro Yonekura, Tamotsu Kanzaki, Nobuaki Nakano, Masahito Tokunaga, Ayumu Kubota, Shogo Takeuchi, Yoshifusa Takatsuka and Atae Utsunomiya

Citation: Retrovirology 2014 11(Suppl 1):P24

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Is age an effect modifier in the relationship between HAM / TSP and depression?

Authors: Ney Boa-Sorte, Ana Verena Galvão-Castro, Danilo Borba, Maria Fernanda Rios Grassi and Bernardo Galvão-Castro

Citation: Retrovirology 2014 11(Suppl 1):P25

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Vestibulospinal tract dysfunction in HTLV-1-asymptomatic infection and in HAM/TSP

Authors: Ludimila Labanca, Ana Lúcia B Starling, Silvio Roberto S Pereira, Luiz Cláudio F Romanelli, Anna Bárbara F Carneiro-Proietti, Lucas N Carvalho, Daniele R Fernandes and Denise U Gonçalves

Citation: Retrovirology 2014 11(Suppl 1):P26

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16th International Conference on Human Retroviruses: HTLV and Related Viruses

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