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  • Open Access

Correlation of HTLV-1 proviral load and lymphocyte proliferation from asymptomatic HTLV-1-positive patients and HAM/TSP patients associated or not to skin disorders

  • 1, 2Email author,
  • 1,
  • 3,
  • 1,
  • 1, 4 and
  • 2
Retrovirology201411 (Suppl 1) :P16

https://doi.org/10.1186/1742-4690-11-S1-P16

  • Published:

Keywords

  • Infectious Disease
  • Cell Count
  • Cancer Research
  • Clinical Status
  • Dermatitis

This study evaluated the prevalence of skin diseases among HTLV-1 infected and the relation between HTLV-1 proviral load, and CD4+ and CD8+ T cells count among, regardless of clinical status, with or without associated skin disorders.193 HTLV-1-infected subjects were studied. Patients were submitted to a complete dermatological examination, lymphocyte proliferation assay (LPA), assay for HTLV-1 proviral load, CD4+ and CD8+ T cells count. A total of 147 patients had an abnormal skin condition; 116 (79%) of these patients also had skin disorder associated with HTLV-1 infection (SD-HTLV-1) (xerosis/ichthyosis or seborrheic dermatitis. The most prevalent SD-HTLV-1 was xerosis/acquired ichthyosis (49%), followed by seborrheic dermatitis (27%). Three of them had the association of adult onset IDH and HAM/TSP. The patients with SD-HTLV-1 were older (51 vs. 47 years), had a higher prevalence of myelopathy/tropical spastic paraparesis (HAM/TSP) (p=0.015), higher HTLV-1 proviral load (p=0.009) and had an increased 3-day basal LPA compared with patients without SD-HTLV-1 (p=0.008). T CD4+ and CD8+ cells counts show no significance. When HAM/TSP patients were excluded from the analysis, the HTLV-1 proviral load showed a significant difference (p=0.021), while LPA showed no difference. There was a high prevalence of skin disorders (76%) among HTLV-1-infected individuals, regardless of clinical status Initial HTLV-1 proviral load and age was higher in SD-HTLV-1 individuals, but the LPA showed an increase only in SD-HTLV-1 subjects with HAM/TSP.

Authors’ Affiliations

(1)
HTLV-outpatient Clinic, Institute of Infectious Diseases “Emilio Ribas”, São Paulo, Brazil
(2)
Department of Dermatology, University of São Paulo Medical School, Brazil
(3)
Department of Clinical Pathology, University of São Paulo Medical School, Brazil
(4)
Institute of Tropical Medicine of São Paulo, University of São Paulo Medical School, Brazil

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