Stress granules inhibit apoptosis by reducing ROS production, but this phenomenon is nullified by HTLV-1 Tax
Retrovirology volume 11, Article number: O52 (2014)
Human T-cell leukemia virus type 1 (HTLV-1) is the etiological agent of adult T-cell leukemia (ATL), and the viral oncoprotein Tax plays key roles in immortalization of human T-cells and leukemogenesis. Here, we identified the ubiquitin-specific protease 10 (USP10) as a Tax-interactor in T-cells. Upon an exposure to arsenic, an oxidative stress inducer, USP10 was recruited into stress granules (SGs), which are the anti-stress machinery. USP10-knockout indicated that USP10, through augmenting formation of SGs, reduced reactive oxygen species (ROS) production and inhibited ROS-dependent apoptosis. Tax mutants and USP10-knockdown indicated that Tax inhibits arsenic-induced SG formation, stimulates ROS production and augments ROS-dependent apoptosis, and they are all dependent on interactions of Tax with USP10. These findings suggest that USP10 is a host factor that controls stress-induced ROS production and apoptosis in HTLV-1-infected T-cells. A clinical trial showed that a combination therapy containing arsenic is effective against some forms of ATL. Thus, these findings may also be relevant to chemotherapy against ATL.
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Takahashi, M., Higuchi, M. & Fujii, M. Stress granules inhibit apoptosis by reducing ROS production, but this phenomenon is nullified by HTLV-1 Tax. Retrovirology 11 (Suppl 1), O52 (2014). https://doi.org/10.1186/1742-4690-11-S1-O52