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  1. Despite the effectiveness of currently available antiretroviral therapies in the treatment of HIV-1 infection, a continuing need exists for novel compounds that can be used in combination with existing drugs t...

    Authors: Jing Zhou, Chin Ho Chen and Christopher Aiken

    Citation: Retrovirology 2004 1:15

    Content type: Research

    Published on:

  2. Apoptosis, or programmed cell death, is a key event in biologic homeostasis but is also involved in the pathogenesis of many human diseases including human immunodeficiency virus (HIV) infection. Although mult...

    Authors: Barbara Ahr, Véronique Robert-Hebmann, Christian Devaux and Martine Biard-Piechaczyk

    Citation: Retrovirology 2004 1:12

    Content type: Review

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  3. Since the discovery of human immunodeficiency virus (HIV-1) twenty years ago, AIDS has become one of the most studied diseases. A number of viruses have subsequently been identified to contribute to the pathog...

    Authors: Elodie Ghedin, Anne Pumfery, Cynthia de la Fuente, Karen Yao, Naomi Miller, Vincent Lacoste, John Quackenbush, Steven Jacobson and Fatah Kashanchi

    Citation: Retrovirology 2004 1:10

    Content type: Research

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  4. During the last two decades, the profusion of HIV research due to the urge to identify new therapeutic targets has led to a wealth of information on the retroviral replication cycle. However, while the late st...

    Authors: Sébastien Nisole and Ali Saïb

    Citation: Retrovirology 2004 1:9

    Content type: Review

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  5. Recent data have established the HIV-1 and SIV escape CTL through epitope mutation. However, three novel studies prove that such escape comes at a "cost" to overall viral fitness. Understanding how HIV-1/SIV e...

    Authors: Stephen M Smith

    Citation: Retrovirology 2004 1:8

    Content type: Commentary

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  6. It is poorly understood why many transforming proteins reportedly enhance both cell growth (transformation) and cell death (apoptosis). At first glance, the ability to transform and the ability to engender apo...

    Authors: Takefumi Kasai and Kuan-Teh Jeang

    Citation: Retrovirology 2004 1:7

    Content type: Research

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  7. The human T-cell leukemia virus type 1 (HTLV-1) Tax protein indirectly influences transcriptional activation, signal transduction, cell cycle control, and apoptosis. The function of Tax primarily relies on pro...

    Authors: Kylene Kehn, Longwen Deng, Cynthia de la Fuente, Katharine Strouss, Kaili Wu, Anil Maddukuri, Shanese Baylor, Robyn Rufner, Anne Pumfery, Maria Elena Bottazzi and Fatah Kashanchi

    Citation: Retrovirology 2004 1:6

    Content type: Research

    Published on:

  8. To generate a replication-competent retrovirus that could be conditionally inactivated, we flanked the viral genes of the Akv murine leukemia virus with LoxP sites. This provirus can delete its envelope gene b...

    Authors: Clifford L Wang, J Graeme Hodgson, Tiffany Malek, Finn Skou Pedersen and Matthias Wabl

    Citation: Retrovirology 2004 1:5

    Content type: Research

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  9. HTLV-I is associated with adult T-cell leukemia, and both HTLV-I and -II are associated with HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Several published reports suggest that HTLV-I may...

    Authors: Jennie R Orland, Baoguang Wang, David J Wright, Catharie C Nass, George Garratty, James W Smith, Bruce Newman, Donna M Smith and Edward L Murphy

    Citation: Retrovirology 2004 1:4

    Content type: Research

    Published on:

  10. We previously described the construction of an HIV-1 envelope glycoprotein complex (Env) that is stabilized by an engineered intermolecular disulfide bond (SOS) between gp120 and gp41. The modified Env protein...

    Authors: Rogier W Sanders, Martijn M Dankers, Els Busser, Michael Caffrey, John P Moore and Ben Berkhout

    Citation: Retrovirology 2004 1:3

    Content type: Research

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  11. CCR5 and CXCR4 are the two main coreceptors essential for HIV entry. Therefore, these chemokine receptors have become important targets in the search for anti-HIV agents. Here, we describe the establishment of...

    Authors: Katrien Princen, Sigrid Hatse, Kurt Vermeire, Erik De Clercq and Dominique Schols

    Citation: Retrovirology 2004 1:2

    Content type: Research

    Published on:

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