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  1. Dicistronic MLV-based retroviral vectors, in which two IRESes independently initiate the translation of two proteins from a single RNA, have been shown to direct co-expression of proteins in several cell cultu...

    Authors: Edmund A Derrington, Marcelo López-Lastra and Jean-Luc Darlix
    Citation: Retrovirology 2005 2:60
  2. Infection by jaagsiekte sheep retrovirus (JSRV) and by enzootic nasal tumor virus (ENTV) depends on cell-surface expression of the virus entry receptor, hyaluronidase 2 (Hyal2). Human Hyal2 binds the envelope ...

    Authors: Fuh-Mei Duh, Clarissa Dirks, Michael I Lerman and A Dusty Miller
    Citation: Retrovirology 2005 2:59
  3. A series of amino acid substitutions (M239F, M239G, P240F, V241G) were placed in the p10-CA protease cleavage site (VVAM*PVVI) to change the rate of cleavage of the junction. The effects of these substitutions...

    Authors: Marcy L Vana, Aiping Chen, Peter Boross, Irene Weber, Dalbinder Colman, Eric Barklis and Jonathan Leis
    Citation: Retrovirology 2005 2:58
  4. The human HERV-W multicopy family includes a unique proviral locus, termed ERVWE1, whose full-length envelope ORF was preserved through evolution by the action of a selective pressure. The encoded Env protein ...

    Authors: Bertrand Bonnaud, Jean Beliaeff, Olivier Bouton, Guy Oriol, Laurent Duret and François Mallet
    Citation: Retrovirology 2005 2:57
  5. A recent publication in Lancet by Dr. David Margolis and colleagues raised the prospect that HIV infection may be curable. In this pilot study, which received much attention from the press, Dr. Margolis'group fou...

    Authors: Stephen M Smith
    Citation: Retrovirology 2005 2:56
  6. Lentiviral vectors have shown immense promise as vehicles for gene delivery to non-dividing cells particularly to cells of the central nervous system (CNS). Improvements in the biosafety of viral vectors are p...

    Authors: Padraig M Strappe, David W Hampton, Douglas Brown, Begona Cachon-Gonzalez, Maeve Caldwell, James W Fawcett and Andrew ML Lever
    Citation: Retrovirology 2005 2:55
  7. The Tax oncoprotein of human T-cell leukemia virus type 1 (HTLV-1) is leukemogenic in transgenic mice and induces permanent T-cell growth in vitro. It is found in active CDK holoenzyme complexes from adult T-cell...

    Authors: Kirsten Fraedrich, Birthe Müller and Ralph Grassmann
    Citation: Retrovirology 2005 2:54
  8. The retroviral phenomenon of superinfection resistance (SIR) defines an interference mechanism that is established after primary infection, preventing the infected cell from being superinfected by a similar ty...

    Authors: Micha Nethe, Ben Berkhout and Antoinette C van der Kuyl
    Citation: Retrovirology 2005 2:52
  9. Endogenous retroviral sequences (ERVs) are integral parts of most eukaryotic genomes and vastly outnumber exogenous retroviruses (XRVs). ERVs with a relatively complete structure were retrieved from the geneti...

    Authors: Patric Jern, Göran O Sperber and Jonas Blomberg
    Citation: Retrovirology 2005 2:50
  10. There is evidence suggesting that actin binding to HIV-1 encoded proteins, or even actin dynamics themselves, might play a key role in virus budding and/or release from the infected cell. A crucial step in the...

    Authors: Gilles Audoly, Michel R Popoff and Pablo Gluschankof
    Citation: Retrovirology 2005 2:48
  11. HIV-1 Tat protein recruits human positive transcription elongation factor P-TEFb, consisting of CDK9 and cyclin T1, to HIV-1 transactivation response (TAR) RNA. CDK9 is maintained in dephosphorylated state by ...

    Authors: Tatyana Ammosova, Kareem Washington, Zufan Debebe, John Brady and Sergei Nekhai
    Citation: Retrovirology 2005 2:47
  12. Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia (ATL), whereas HTLV type 2 (HTLV-2), is not associated with ATL or any other leukemia. HTLV-1 encodes the transformin...

    Authors: Chikako Tsubata, Masaya Higuchi, Masahiko Takahashi, Masayasu Oie, Yuetsu Tanaka, Fumitake Gejyo and Masahiro Fujii
    Citation: Retrovirology 2005 2:46
  13. The HTLV-1 Tax oncoprotein rapidly induces cytogenetic damage which can be measured by a significant increase in the number of micronuclei (MN) in cells. Tax is thought to have both aneuploidogenic and clastog...

    Authors: Franca Majone, Roberto Luisetto, Daniela Zamboni, Yoichi Iwanaga and Kuan-Teh Jeang
    Citation: Retrovirology 2005 2:45
  14. We determined the relative ratios of Gag and Pol molecules in highly purified virions of spumaretroviruses or foamy viruses (FVs) using monoclonal antibodies and bacterially expressed reference proteins. We fo...

    Authors: Marc Cartellieri, Wolfram Rudolph, Ottmar Herchenröder, Dirk Lindemann and Axel Rethwilm
    Citation: Retrovirology 2005 2:44
  15. The positive transcription elongation factor b (P-TEFb) composed by CDK9/CyclinT1 subunits is a dedicated co-factor of HIV transcriptional transactivator Tat protein. Transcription driven by the long terminal ...

    Authors: Alessandro Fraldi, Francesca Varrone, Giuliana Napolitano, Annemieke A Michels, Barbara Majello, Olivier Bensaude and Luigi Lania
    Citation: Retrovirology 2005 2:42
  16. The actual relationship between viral variability and HIV disease progression and/or non-progression can only be extrapolated through epidemiologically-linked HIV-infected cohorts. The rarity of such cohorts a...

    Authors: Meriet Mikhail, Bin Wang, Philippe Lemey, Brenda Beckthold, Anne-Mieke Vandamme, M John Gill and Nitin K Saksena
    Citation: Retrovirology 2005 2:41
  17. GBV-C virus infection has been linked to improved clinical outcome in HIV-1 co-infected individuals. The epidemiology of GBV-C has, thus far, been limited to the gay male, HIV+ population. Here we describe the pr...

    Authors: Stephen M Smith, Michael J Donio, Mahender Singh, James P Fallon, Lavanya Jitendranath, Natalia Chkrebtii, Jihad Slim, Diana Finkel and George Perez
    Citation: Retrovirology 2005 2:38
  18. APOBEC3G is a cellular cytidine deaminase that was recently identified as the Vif-sensitive antiviral host factor responsible for the restriction of vif-defective HIV-1 in primary human cells and certain non-perm...

    Authors: Klaus Strebel
    Citation: Retrovirology 2005 2:37
  19. The reverse transcriptase (RT) enzyme of human immunodeficiency virus type 1 (HIV-1) plays a crucial role in the life cycle of the virus by converting the single stranded RNA genome into double stranded DNA th...

    Authors: Vasudha Sundaravaradan, Tobias Hahn and Nafees Ahmad
    Citation: Retrovirology 2005 2:36
  20. Apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3G (APOBEC3G) is a host cellular protein with a broad antiviral activity. It inhibits infectivitiy of a wide variety of retroviruses by deaminati...

    Authors: Amane Sasada, Akifumi Takaori-Kondo, Kotaro Shirakawa, Masayuki Kobayashi, Aierkin Abudu, Masakatsu Hishizawa, Kazunori Imada, Yuetsu Tanaka and Takashi Uchiyama
    Citation: Retrovirology 2005 2:32
  21. Retroviral integration is central to viral persistence and pathogenesis, cancer as well as host genome evolution. However, it is unclear why integration appears essential for retrovirus production, especially ...

    Authors: Olivier Delelis, Caroline Petit, Herve Leh, Gladys Mbemba, Jean-François Mouscadet and Pierre Sonigo
    Citation: Retrovirology 2005 2:31
  22. Human T-cell Leukemia virus type 1 (HTLV-1) and type 2 (HTLV-2) are pathogenic retroviruses that infect humans and cause severe hematological and neurological diseases. Both viruses have simian counterparts (S...

    Authors: Sara Calattini, Sébastien Alain Chevalier, Renan Duprez, Sylviane Bassot, Alain Froment, Renaud Mahieux and Antoine Gessain
    Citation: Retrovirology 2005 2:30
  23. Human T-cell leukemia virus type 1 (HTLV-1) is associated with the development of adult T-cell leukemia (ATL). HTLV-1 encoded Tax1 oncoprotein activates the transcription of genes involved in cell growth and a...

    Authors: Masaya Higuchi, Takehiro Matsuda, Naoki Mori, Yasuaki Yamada, Ryouichi Horie, Toshiki Watanabe, Masahiko Takahashi, Masayasu Oie and Masahiro Fujii
    Citation: Retrovirology 2005 2:29
  24. Reducing transmission of HIV-1 through breast milk is needed to help decrease the burden of pediatric HIV/AIDS in society. We have previously reported that alkyl sulfates (i.e., sodium dodecyl sulfate, SDS) ar...

    Authors: Sandra Urdaneta, Brian Wigdahl, Elizabeth B Neely, Cheston M Berlin Jr, Cara-Lynne Schengrund, Hung-Mo Lin and Mary K Howett
    Citation: Retrovirology 2005 2:28
  25. The first Dominique Dormont International Conference on "Viral and host determinantsof HCV, HCMV, and HIV infections "was held in Paris, Val-de-Grâce, on December 3–4, 2004. The following is a summary of the s...

    Authors: Elisabeth Menu, Mickaela C Müller-Trutwin, Gianfranco Pancino, Asier Saez-Cirion, Christine Bain, Geneviève Inchauspé, Gabriel S Gras, Aloïse M Mabondzo, Assia Samri, Françoise Boutboul and Roger Le Grand
    Citation: Retrovirology 2005 2:24
  26. Human T-lymphotropic virus type 1 (HTLV-1) and HTLV-2 were among the first human retroviruses discovered in the early 1980's. The International Retrovirology Association is an organized effort that fostered th...

    Authors: Edward Murphy, Steven Jacobson, Genoveffa Franchini, Graham P Taylor, Barrie Hanchard, Owen Morgan and Michael Lairmore
    Citation: Retrovirology 2005 2:22
  27. All human immunodeficiency virus (HIV-1) uses a host tRNALys,3 as the primer for reverse transcription. The tRNALys,3 is bound to a region on the HIV-1 genome, the primer-binding site (PBS), that is complementary...

    Authors: Kenda L Moore-Rigdon, Barry R Kosloff, Richard L Kirkman and Casey D Morrow
    Citation: Retrovirology 2005 2:21
  28. Despite the success of HAART, patients often stop treatment due to the inception of side effects. Furthermore, viral resistance often develops, making one or more of the drugs ineffective. Identification of no...

    Authors: Winnie S Liang, Anil Maddukuri, Tanya M Teslovich, Cynthia de la Fuente, Emmanuel Agbottah, Shabnam Dadgar, Kylene Kehn, Sampsa Hautaniemi, Anne Pumfery, Dietrich A Stephan and Fatah Kashanchi
    Citation: Retrovirology 2005 2:20
  29. Most Internet online resources for investigating HIV biology contain either bioinformatics tools, protein information or sequence data. The objective of this study was to develop a comprehensive online proteom...

    Authors: Ryan S Doherty, Tulio De Oliveira, Chris Seebregts, Sivapragashini Danaviah, Michelle Gordon and Sharon Cassol
    Citation: Retrovirology 2005 2:18
  30. Adult T-cell leukemia (ATL) was first reported as a distinct clinical entity in 1977 in Japan. The predominant physical findings are skin lesions, lymphadenopathy and hepatosplenomegaly. The ATL cells are of m...

    Authors: Kiyoshi Takatsuki
    Citation: Retrovirology 2005 2:16
  31. On February 11, 2005, the New York City Department of Health and Mental Hygiene announced that a city resident had recently been infected with a multi-drug resistant form of HIV and rapidly progressed to AIDS....

    Authors: Stephen M Smith
    Citation: Retrovirology 2005 2:14
  32. New York City health officials announced on February 11, 2005 that a patient rapidly developed full-blown AIDS shortly after being diagnosed with a rare, drug-resistant strain of HIV-1. The New York City Depar...

    Authors: Ben Berkhout, Anthony de Ronde and Lia van der Hoek
    Citation: Retrovirology 2005 2:13

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