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  1. MOV10 protein has ATP-dependent 5′–3′ RNA helicase activity and belongs to the UPF1p superfamily. It can inhibit human immunodeficiency virus type 1 (HIV-1) replication at multiple stages and interact with apo...

    Authors: Cancan Chen, Xiaocao Ma, Qifei Hu, Xinghua Li, Feng Huang, Junsong Zhang, Ting Pan, Jinyu Xia, Chao Liu and Hui Zhang
    Citation: Retrovirology 2017 14:56
  2. Foamy viruses (FV) are ancient complex retroviruses that differ from orthoretroviruses such as human immunodeficiency virus (HIV) and murine leukemia virus (MLV) and comprise a distinct subfamily of retrovirus...

    Authors: Delia M. Pinto-Santini, Carolyn R. Stenbak and Maxine L. Linial
    Citation: Retrovirology 2017 14:55
  3. Stable insertion of the retroviral DNA genome into host chromatin requires the functional association between the intasome (integrase·viral DNA complex) and the nucleosome. The data from the literature suggest...

    Authors: Mohamed S. Benleulmi, Julien Matysiak, Xavier Robert, Csaba Miskey, Eric Mauro, Delphine Lapaillerie, Paul Lesbats, Stéphane Chaignepain, Daniel R. Henriquez, Christina Calmels, Oyindamola Oladosu, Eloïse Thierry, Oscar Leon, Marc Lavigne, Marie-Line Andreola, Olivier Delelis…
    Citation: Retrovirology 2017 14:54
  4. The CRISPR/Cas9 system has been widely used for genome editing in mammalian cells. CXCR4 is a co-receptor for human immunodeficiency virus type 1 (HIV-1) entry, and loss of CXCR4 function can protect cells from C...

    Authors: Qiankun Wang, Shuliang Chen, Qiaoqiao Xiao, Zhepeng Liu, Shuai Liu, Panpan Hou, Li Zhou, Wei Hou, Wenzhe Ho, Chunmei Li, Li Wu and Deyin Guo
    Citation: Retrovirology 2017 14:51
  5. HIV-1 Integrase (IN) interacts with the cellular co-factor LEDGF/p75 and tethers the HIV preintegration complex to the host genome enabling integration. Recently a new class of IN inhibitors was described, th...

    Authors: Céline Amadori, Yme Ubeles van der Velden, Damien Bonnard, Igor Orlov, Nikki van Bel, Erwann Le Rouzic, Laia Miralles, Julie Brias, Francis Chevreuil, Daniele Spehner, Sophie Chasset, Benoit Ledoussal, Luzia Mayr, François Moreau, Felipe García, José Gatell…
    Citation: Retrovirology 2017 14:50
  6. The human immunodeficiency virus type 1 (HIV-1) structural protein Gag is necessary and sufficient to form viral particles. In addition to encoding the amino acid sequence for Gag, the underlying RNA sequence ...

    Authors: Irati Antzin-Anduetza, Charlotte Mahiet, Luke A. Granger, Charlotte Odendall and Chad M. Swanson
    Citation: Retrovirology 2017 14:49
  7. The authors wish to apologize for an error within the scale bar of the microarray heatmap in Additional File 5 of the supplementary information. Two values were incorrectly displayed on the scale bar (11 inste...

    Authors: Franziska K. Geis, Melanie Galla, Dirk Hoffmann, Johannes Kuehle, Daniela Zychlinski, Tobias Maetzig, Juliane W. Schott, Adrian Schwarzer, Christine Goffinet, Stephen P. Goff and Axel Schambach
    Citation: Retrovirology 2017 14:48

    The original article was published in Retrovirology 2017 14:34

  8. In patients with HIV/AIDS receiving antiretroviral therapy (ART), HIV-1 persistence in brain tissue is a vital and unanswered question. HIV-1 infects and replicates in resident microglia and trafficking macrop...

    Authors: Eugene L. Asahchop, Oussama Meziane, Manmeet K. Mamik, Wing F. Chan, William G. Branton, Lothar Resch, M. John Gill, Elie Haddad, Jean V. Guimond, Mark A. Wainberg, Glen B. Baker, Eric A. Cohen and Christopher Power
    Citation: Retrovirology 2017 14:47
  9. Mutations rapidly accumulate in the HIV-1 genome after infection. Some of those mutations are selected by host immune responses and often cause viral fitness losses. This study is to investigate whether strong...

    Authors: Donglai Liu, Chu Wang, Bhavna Hora, Tao Zuo, Nilu Goonetilleke, Michael K. P. Liu, Mark Berrong, Guido Ferrari, Andrew J. McMichael, Tanmoy Bhattacharya, Alan S. Perelson and Feng Gao
    Citation: Retrovirology 2017 14:46
  10. Like all viruses, HIV-1 relies on host systems to replicate. The human purinome consists of approximately two thousand proteins that bind and use purines such as ATP, NADH, and NADPH. By virtue of their purin...

    Authors: Manjusha M. Kulkarni, Annette N. Ratcliff, Menakshi Bhat, Yazan Alwarawrah, Philip Hughes, Jesus Arcos, David Loiselle, Jordi B. Torrelles, Nicholas T. Funderburg, Timothy A. Haystead and Jesse J. Kwiek
    Citation: Retrovirology 2017 14:45
  11. The CD4-induced (CD4i) epitopes in gp120 includes the co-receptor binding site, which are formed and exposed after interaction with CD4. Monoclonal antibodies (mAbs) to the CD4i epitopes exhibit limited neutra...

    Authors: Kazuki Tanaka, Takeo Kuwata, Muntasir Alam, Gilad Kaplan, Shokichi Takahama, Kristel Paola Ramirez Valdez, Anna Roitburd-Berman, Jonathan M. Gershoni and Shuzo Matsushita
    Citation: Retrovirology 2017 14:44
  12. The HIV-1 RNA genome has a biased nucleotide composition with a surplus of As. Several hypotheses have been put forward to explain this striking phenomenon, but the A-count of the HIV-1 genome has thus far not...

    Authors: Bep Klaver, Yme van der Velden, Formijn van Hemert, Antoinette C. van der Kuyl and Ben Berkhout
    Citation: Retrovirology 2017 14:43
  13. Myeloid-derived suppressor cells (MDSCs) can suppress T cell responses in several different diseases. Previously these suppressive cells were observed to expand in HIV patients and in a mouse retrovirus model,...

    Authors: Malgorzata Drabczyk-Pluta, Tanja Werner, Daniel Hoffmann, Qibin Leng, Lieping Chen, Ulf Dittmer and Gennadiy Zelinskyy
    Citation: Retrovirology 2017 14:42
  14. Human endogenous retroviruses (HERVs) comprise approximately 8% of the human genome and while the majority are transcriptionally silent, the most recently integrated HERV, HERV-K (HML-2), remains active. Durin...

    Authors: Miguel de Mulder, Devi SenGupta, Steven G. Deeks, Jeffrey N. Martin, Christopher D. Pilcher, Frederick M. Hecht, Jonah B. Sacha, Douglas F. Nixon and Henri-Alexandre Michaud
    Citation: Retrovirology 2017 14:41
  15. Rev-like proteins are post-transcriptional regulatory proteins found in several retrovirus genera, including lentiviruses, betaretroviruses, and deltaretroviruses. These essential proteins mediate the nuclear ...

    Authors: Chijioke N. Umunnakwe, Karin S. Dorman, Drena Dobbs and Susan Carpenter
    Citation: Retrovirology 2017 14:40
  16. Insertion of retroviral genome DNA occurs in the chromatin of the host cell. This step is modulated by chromatin structure as nucleosomes compaction was shown to prevent HIV-1 integration and chromatin remodel...

    Authors: Julien Matysiak, Paul Lesbats, Eric Mauro, Delphine Lapaillerie, Jean-William Dupuy, Angelica P. Lopez, Mohamed Salah Benleulmi, Christina Calmels, Marie-Line Andreola, Marc Ruff, Manuel Llano, Olivier Delelis, Marc Lavigne and Vincent Parissi
    Citation: Retrovirology 2017 14:39
  17. Integrase strand transfer inhibitors (INSTIs) are the newest class of antiretroviral drugs to be approved for treatment and act by inhibiting the essential HIV protein integrase from inserting the viral DNA ge...

    Authors: Kaitlin Anstett, Bluma Brenner, Thibault Mesplede and Mark A. Wainberg
    Citation: Retrovirology 2017 14:36
  18. Simian immunodeficiency virus of chimpanzees (SIVcpz), the progenitor of human immunodeficiency virus type 1 (HIV-1), is associated with increased mortality and AIDS-like immunopathology in wild-living chimpan...

    Authors: Hannah J. Barbian, Raven Jackson-Jewett, Corrine S. Brown, Frederic Bibollet-Ruche, Gerald H. Learn, Timothy Decker, Edward F. Kreider, Yingying Li, Thomas N. Denny, Paul M. Sharp, George M. Shaw, Jeffrey Lifson, Edward P. Acosta, Michael S. Saag, Katharine J. Bar and Beatrice H. Hahn
    Citation: Retrovirology 2017 14:35
  19. Retroviral vectors are derived from wild-type retroviruses, can be used to study retrovirus-host interactions and are effective tools in gene and cell therapy. However, numerous cell types are resistant or les...

    Authors: Franziska K. Geis, Melanie Galla, Dirk Hoffmann, Johannes Kuehle, Daniela Zychlinski, Tobias Maetzig, Juliane W. Schott, Adrian Schwarzer, Christine Goffinet, Stephen P. Goff and Axel Schambach
    Citation: Retrovirology 2017 14:34

    The Correction to this article has been published in Retrovirology 2017 14:48

  20. Parent-offspring (PO) regression is a central tool to determine the heritability of phenotypic traits; i.e., the relative extent to which those traits are controlled by genetic factors. The applicability of PO...

    Authors: Nadine Bachmann, Teja Turk, Claus Kadelka, Alex Marzel, Mohaned Shilaih, Jürg Böni, Vincent Aubert, Thomas Klimkait, Gabriel E. Leventhal, Huldrych F. Günthard and Roger Kouyos
    Citation: Retrovirology 2017 14:33
  21. Apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3 (APOBEC3) proteins are mammalian-specific cellular deaminases and have a robust ability to restrain lentivirus replication. To antagonize APOBE...

    Authors: Yusuke Nakano, Hirofumi Aso, Andrew Soper, Eri Yamada, Miyu Moriwaki, Guillermo Juarez-Fernandez, Yoshio Koyanagi and Kei Sato
    Citation: Retrovirology 2017 14:31
  22. Authors: Monsef Benkirane, Ben Berkhout, Persephone Borrow, Ariberto Fassati, Masahiro Fujii, J. Victor Garcia, Paul Gorry, Andrew Lever, Johnson Mak, Monique Nijhuis, Klaus Strebel, Francois Venter and Robin Weiss
    Citation: Retrovirology 2017 14:30
  23. Ongoing intra-host HIV-1 evolution has been shown in individuals that naturally suppress the viremia to low levels (HIV controllers) by the analysis of the RNA in plasma compartment. Detection of evolution at ...

    Authors: Suwellen S. D. de Azevedo, Diogo Gama Caetano, Fernanda H. Côrtes, Sylvia L. M. Teixeira, Karina dos Santos Silva, Brenda Hoagland, Beatriz Grinsztejn, Valdilea G. Veloso, Mariza G. Morgado and Gonzalo Bello
    Citation: Retrovirology 2017 14:29
  24. Retroviral envelope (Env) proteins are known to exhibit immunosuppressive properties, which become apparent not only in retroviral infections, but also in gene-based immunizations using retroviral immunogens, ...

    Authors: Nadine Bongard, Dennis Lapuente, Sonja Windmann, Ulf Dittmer, Matthias Tenbusch and Wibke Bayer
    Citation: Retrovirology 2017 14:28
  25. Human endogenous retroviruses (HERVs), the remnants of ancient retroviral infections, constitute approximately 8% of human genomic DNA. Since HERV-K Gag expression is induced by HIV-1 Tat in T cells, induced H...

    Authors: Kazuaki Monde, Hiromi Terasawa, Yusuke Nakano, Ferri Soheilian, Kunio Nagashima, Yosuke Maeda and Akira Ono
    Citation: Retrovirology 2017 14:27
  26. Although human T-lymphotropic virus type 1 (HTLV-1) infection is a prerequisite for the development of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), specific provirus mutations in HAM/TS...

    Authors: Satoshi Nozuma, Eiji Matsuura, Daisuke Kodama, Yuichi Tashiro, Toshio Matsuzaki, Ryuji Kubota, Shuji Izumo and Hiroshi Takashima
    Citation: Retrovirology 2017 14:26
  27. APOBEC3/Rfv3 restricts acute Friend retrovirus (FV) infection and promotes virus-specific neutralizing antibody (NAb) responses. Classical Rfv3 studies utilized FV stocks containing lactate-dehydrogenase eleva...

    Authors: Bradley S. Barrett, Michael S. Harper, Sean T. Jones, Kejun Guo, Karl J. Heilman, Ross M. Kedl, Kim J. Hasenkrug and Mario L. Santiago
    Citation: Retrovirology 2017 14:25
  28. Bovine leukemia virus (BLV) is the causative agent of enzootic bovine leukosis, a malignant B cell lymphoma that has spread worldwide and causes serious problems for the cattle industry. The BLV proviral load,...

    Authors: Shin-nosuke Takeshima, Shinji Sasaki, Polat Meripet, Yoshikazu Sugimoto and Yoko Aida
    Citation: Retrovirology 2017 14:24
  29. It is well established that most new systemic infections of HIV-1 can be traced back to one or a limited number of founder viruses. Usually, these founders are more closely related to minor HIV-1 populations i...

    Authors: Samuel Mundia Kariuki, Philippe Selhorst, Kevin K. Ariën and Jeffrey R. Dorfman
    Citation: Retrovirology 2017 14:22
  30. Human endogenous retroviruses (HERVs) are genomic sequences of retroviral origin which were believed to be integrated into germline chromosomes millions of years ago and account for nearly 8% of the human geno...

    Authors: Richa Tyagi, Wenxue Li, Danelvis Parades, Mario A. Bianchet and Avindra Nath
    Citation: Retrovirology 2017 14:21
  31. Syncytin-1 and 2, human fusogenic glycoproteins encoded by the env genes of the endogenous retroviral loci ERVWE1 and ERVFRDE1, respectively, contribute to the differentiation of multinucleated syncytiotropho...

    Authors: Martina Benešová, Kateřina Trejbalová, Denisa Kovářová, Zdenka Vernerová, Tomáš Hron, Dana Kučerová and Jiří Hejnar
    Citation: Retrovirology 2017 14:20
  32. HIV-1 Vif interacts with the cellular core-binding factor β (CBFβ) and counteracts the protective roles of certain human APOBEC3 (A3) proteins by targeting them for proteasomal degradation. Previous studies ha...

    Authors: Belete A. Desimmie, Jessica L. Smith, Hiroshi Matsuo, Wei-Shau Hu and Vinay K. Pathak
    Citation: Retrovirology 2017 14:19
  33. Despite improved clinical outcomes seen following antiretroviral therapy (ART), resting CD4+ T cells continue to harbor latent human immunodeficiency virus type one (HIV-1). However, such cells are not likely ...

    Authors: Mariluz Araínga, Benson Edagwa, R. Lee Mosley, Larisa Y. Poluektova, Santhi Gorantla and Howard E. Gendelman
    Citation: Retrovirology 2017 14:17
  34. Prototype foamy virus (PFV) is a member of the Spumaretrovirinae subfamily of retroviruses, which maintains lifelong latent infection while being nonpathogenic to their natural hosts. Autophagy is a cell-progr...

    Authors: Peipei Yuan, Lanlan Dong, Qingqing Cheng, Shuang Wang, Zhi Li, Yan Sun, Song Han, Jun Yin, Biwen Peng, Xiaohua He and Wanhong Liu
    Citation: Retrovirology 2017 14:16
  35. Recently, Oberle et al. published a paper in Retrovirology evaluating the question of whether selection plays a role in HIV transmission. The Oberle study found no obvious genotypic or phenotypic differences betw...

    Authors: Mileidy Gonzalez, Anthony L. DeVico and John L. Spouge
    Citation: Retrovirology 2017 14:13
  36. Characterizing HIV-1 transmission networks can be important in understanding the evolutionary patterns and geospatial spread of the epidemic. We reconstructed the broad molecular epidemiology of HIV from indiv...

    Authors: Antoine Chaillon, Asma Essat, Pierre Frange, Davey M. Smith, Constance Delaugerre, Francis Barin, Jade Ghosn, Gilles Pialoux, Olivier Robineau, Christine Rouzioux, Cécile Goujard, Laurence Meyer and Marie-Laure Chaix
    Citation: Retrovirology 2017 14:15
  37. A20-binding inhibitor of NF-κB activation (ABIN1), an important immune regulator, was previously shown to be involved in HIV-1 replication. However, the reported studies done with overexpressed ABIN1 provided ...

    Authors: Shiyou Chen, Xiaodan Yang, Weijia Cheng, Yuhong Ma, Yafang Shang, Liu Cao, Shuliang Chen, Yu Chen, Min Wang and Deyin Guo
    Citation: Retrovirology 2017 14:12
  38. The foamy viral genome encodes four central purine-rich elements localized in the integrase-coding region of pol. Previously, we have shown that the first two of these RNA elements (A and B) are required for prot...

    Authors: Rebecca Moschall, Sarah Denk, Steffen Erkelenz, Christian Schenk, Heiner Schaal and Jochen Bodem
    Citation: Retrovirology 2017 14:10
  39. Multiple toll-like receptors (TLRs) are expressed in cells of the monocytic lineage, including microglia, which constitute the major reservoir for human immunodeficiency virus (HIV) infection in the brain. We ...

    Authors: David Alvarez-Carbonell, Yoelvis Garcia-Mesa, Stephanie Milne, Biswajit Das, Curtis Dobrowolski, Roxana Rojas and Jonathan Karn
    Citation: Retrovirology 2017 14:9
  40. In the Friend retrovirus mouse model we developed potent adenovirus-based vaccines that were designed to induce either strong Friend virus GagL85–93-specific CD8+ T cell or antibody responses, respectively. To op...

    Authors: Meike Kaulfuß, Ina Wensing, Sonja Windmann, Camilla Patrizia Hrycak and Wibke Bayer
    Citation: Retrovirology 2017 14:8

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