Volume 12 Supplement 1

17th International Conference on Human Retroviruses: HTLV and Related Viruses

Meeting abstracts

Edited by Raymond Cesaire, Agnès Lézin and Jean-Marie Péloponèse Jr

Publication of this supplement was funded by EU PO-FEDER of Martinique. The Supplement Editors declare that they have no competing interests.

17th International Conference on Human Retroviruses: HTLV and Related Viruses. Go to conference site.

Trois Ilets, Martinique18-21 June 2015

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17th International Conference on Human Retroviruses: HTLV and Related Viruses, Trois Ilets, Martinique,(FWI). 18-21 June 2015

Authors: Raymond Cesaire, Agnès Lézin and Jean-Marie Péloponèse Jr

Citation: Retrovirology 2015 12(Suppl 1):I1

Content type: Introduction

Published on: 28 August 2015
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HTLV-1 subtype C infection in a socially disadvantaged Indigenous Australian population: epidemiological insights from a retrospective hospital-based cohort study

Authors: Lloyd Einsiedel, Richard Woodman, Maria Flynn, Clinton Pepperill, Kim Wilson, Olivier Cassar and Antoine Gessain

Citation: Retrovirology 2015 12(Suppl 1):O1

Content type: Oral presentation

Published on: 28 August 2015
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HAM-net national patient registration system reveals details of how Japanese patients with HTLV-1-associated myelopathy/tropical spastic paraparesis progress over time

Authors: Ariella Coler-Reilly, Naoko Yagishita, Tomoo Sato, Natsumi Araya, Miho Ishikawa, Mikako Koike, Yumi Saito, Hiroko Suzuki, Yoshihisa Yamano and Ayako Takata

Citation: Retrovirology 2015 12(Suppl 1):O2

Content type: Oral presentation

Published on: 28 August 2015
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Evidence of a predominance of sexual transmission of HTLV-1 in Salvador, the city with the highest prevalence in Brazil

Authors: David Nunes, Ney Boa-Sorte, Maria Fernanda Rios Grassi, Kleber Pimentel, Maria Gloria Teixeira, Mauricio L Barreto, Inês Dourado and Bernardo Galvão-Castro

Citation: Retrovirology 2015 12(Suppl 1):O3

Content type: Oral presentation

Published on: 28 August 2015
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Estimating the number of HTLV-2 infected persons in the world

Authors: Edward L Murphy, Olivier Cassar and Antoine Gessain

Citation: Retrovirology 2015 12(Suppl 1):O5

Content type: Oral presentation

Published on: 28 August 2015
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Temporal Trends in HAM/TSP incidence in Martinique over 25 years (1986-2010): dramatic decrease since 2000

Authors: Stephane Olindo, Severine Jeannin, Martine Saint-Vil, Aissatou Signate, Mireille Edimonana-Kaptue, Julien Joux, Philippe Cabre, Raymond Cesaire, Agnes Lezin and Didier Smadja

Citation: Retrovirology 2015 12(Suppl 1):O6

Content type: Oral presentation

Published on: 28 August 2015
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Prevalence of HTLV-1 infection in northeast of Iran

Authors: Reza Farid, Farhad Farid and Safai A Rezaee

Citation: Retrovirology 2015 12(Suppl 1):O7

Content type: Oral presentation

Published on: 28 August 2015
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Functional comparison of the HTLV-1 and HTLV-2 antisense viral proteins: implications for pathogenesis

Authors: Amanda R Panfil, Nathan Dissinger, Kristina Landes and Patrick L Green

Citation: Retrovirology 2015 12(Suppl 1):O8

Content type: Oral presentation

Published on: 28 August 2015
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The bovine leukemia virus microRNAs permit escape from innate immune response and contribute to viral replication in the natural host

Authors: Nicolas A Gillet, Malik Hamaidia, Alix de Brogniez, Gerónimo Gutiérrez, Nathalie Renotte, Michal Reichert, Karina Trono and Luc Willems

Citation: Retrovirology 2015 12(Suppl 1):O9

Content type: Oral presentation

Published on: 28 August 2015
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Identification of long-range chromatin interactions between HTLV-1 and the host genome

Authors: Hiroko Yaguchi, Anat Melamed, Aileen Rowan, Lucy Cook, Yorifumi Satou and Charles R M Bangham

Citation: Retrovirology 2015 12(Suppl 1):O10

Content type: Oral presentation

Published on: 28 August 2015
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In vivo characterization of the BLV miRNA cluster

Authors: Anthony Rodari, Benoît Van Driessche, Nadège Delacourt, Caroline Vanhulle, Arsène Burny, Anne Van den Broeke, Olivier Rohr and Carine Van Lint

Citation: Retrovirology 2015 12(Suppl 1):O11

Content type: Oral presentation

Published on: 28 August 2015
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Recurrent TET2 mutations in adult T cell leukemia (ATL) and identification of a Single Nucleotide polymorphism in TET2 region predisposing to ATL development

Authors: Ambroise Marçais, Katia Hanssens, Laetitia Waast, Vahid Asnafi, Patrice Dubreuil, Antoine Gessain, Claudine Pique and Olivier Hermine

Citation: Retrovirology 2015 12(Suppl 1):O12

Content type: Oral presentation

Published on: 28 August 2015
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EZH2 dependent epigenetic landscape in adult T cell leukemia and Tax immortalized cells

Authors: Dai Fujikawa, Makoto Yamagishi, Shota Nakagawa, Naoya Kurokawa, Ai Soejima, Seiichirou Kobayashi, Kaoru Uchimaru, Yuetsu Tanaka, Kazumi Nakano and Toshiki Watanabe

Citation: Retrovirology 2015 12(Suppl 1):O13

Content type: Oral presentation

Published on: 28 August 2015
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Characteristics of HAM/TSP after kidney transplantation from HTLV-1 positive living donors

Authors: Miyuna Kimura, Junji Yamauchi, Hideki Taisho, Tomoo Sato, Naoko Yagishita, Natsumi Araya, Kentaro Sato, Takayuki Kikuchi, Yasuhiro Hasegawa, Tatsuya Chikaraishi, Yuugo Shibagaki and Yoshihisa Yamano

Citation: Retrovirology 2015 12(Suppl 1):O14

Content type: Oral presentation

Published on: 28 August 2015
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Prospective studies of allogeneic hema topoietic stem cell transplantation for adult T-cell leukemia-lymphoma

Authors: Ilseung Cho, Atae Utsunomiya, Ryuji Tanosaki, Tetsuya Eto, Takahiro Fukuda, Youko Suehiro, Mari Kannagi, Jun Okamura and Naokuni Uike

Citation: Retrovirology 2015 12(Suppl 1):O16

Content type: Oral presentation

Published on: 28 August 2015
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Comparison of walking measures in patients with HTLV-1 Associated Myelopathy

Authors: Adine Adonis and Graham P Taylor

Citation: Retrovirology 2015 12(Suppl 1):O17

Content type: Oral presentation

Published on: 28 August 2015
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A three-factor plasma diagnostic model of human T -cell leukemia virus-1 associated myelopathy

Authors: Makoto Ishihara, Natsumi Araya, Tomoo Sato, Naomi Saichi, Risa Fujii, Yoshihisa Yamano and Koji Ueda

Citation: Retrovirology 2015 12(Suppl 1):O18

Content type: Oral presentation

Published on: 28 August 2015
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The clinical spectrum of HTLV-1 infection

Authors: Davi Tanajura, Abraão Neto, Isadora Siqueira, Valéria Gusmão, Paulo Oliveira, Silvana Giozza, Neviton Castro, Natalia Carvalho, Silvane Santos and Edgar M Carvalho

Citation: Retrovirology 2015 12(Suppl 1):O19

Content type: Oral presentation

Published on: 28 August 2015
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Tax as a therapeutic target in ATL

Authors: Zeina Dassouki, Umut Sahin, Hiba El Hajj, Florence Jollivet, Youmna Kfoury, Valérie Lallemand-Breitenbach, Olivier Hermine, Hugues de The and Ali Bazarbachi

Citation: Retrovirology 2015 12(Suppl 1):O20

Content type: Oral presentation

Published on: 28 August 2015
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Deep sequencing of the TCRβ repertoire reveals T cell clonal expansion is associated with HTLV-1 proviral load in HAM/TSP patients

Authors: Alessandra de Paula A Sousa, Kory R Johnson, Joan Ohayon, Jun Zhu, Paolo Muraro and Steven Jacobson

Citation: Retrovirology 2015 12(Suppl 1):O21

Content type: Oral presentation

Published on: 28 August 2015
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A multi-cytokine inhibitory peptide (BNZ 132-1) that is a potential therapeutic agent for HAMTSP and other necrotizing diseases.

Authors: Toshie Nata, Juan Carlos Zapata, Raya Massoud, Steve Jacobson, Nazli Azimi and Yutaka Tagaya

Citation: Retrovirology 2015 12(Suppl 1):O22

Content type: Oral presentation

Published on: 28 August 2015
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Humanized anti CCR4 antibody KW0761 targets HTLV-1 infected CD4+ CCR4+ and CD8+CCR4+ T cells to treat HAM/TSP

Authors: Yoshihisa Yamano, Junji Yamauchi, Ariella Coler-Reilly, Tomoo Sato, Natsumi Araya, Naoko Yagishita, Yasuo Kunitomo, Katsunori Takahashi, Yuetsu Tanaka, Hisanao Akiyama, Yasuhiro Hasegawa and Atae Utsunomiya

Citation: Retrovirology 2015 12(Suppl 1):O23

Content type: Oral presentation

Published on: 28 August 2015
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HTLV-1 infection interferes with immune responses to Mycobacterium tuberculosis antigens

Authors: Natália B Carvalho, Maria de Lourdes Bastos, Yuri Neves, Anselmo Souza, Eduardo Martins Netto, Silvane Santos and Edgar M Carvalho

Citation: Retrovirology 2015 12(Suppl 1):O24

Content type: Oral presentation

Published on: 28 August 2015
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Monocyte accumulation is an early event in HAM/TSP pathogenesis, while monocyte activation and IFN-regulated gene expression persist in chronic HAM/TSP

Authors: Soraya Maria Menezes, Harry Freitag Muhammad, George Soares, Ricardo Khouri, Daniele Decanine, Gilvaneia Silva Santos, Saul Velloso Schnitman, Ramon Kruschewsky, Giovanni López, Carolina Alvarez, Michael Talledo, Eduardo Gotuzzo, Bernardo Galvão-Castro and Johan Van Weyenbergh

Citation: Retrovirology 2015 12(Suppl 1):O25

Content type: Oral presentation

Published on: 28 August 2015
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Tumor suppressor in lung cancer identifies latency infected cells in non malignant HTLV-1 infection

Authors: Kiruthika Manivannan, Aileen G Rowan, Graham P Taylor and Charles RM Bangham

Citation: Retrovirology 2015 12(Suppl 1):O26

Content type: Oral presentation

Published on: 28 August 2015
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Host determinants of HTLV-1 integration site preference

Authors: Amy J McCallin, Goedele N Maertens and Charles RM Bangham

Citation: Retrovirology 2015 12(Suppl 1):O27

Content type: Oral presentation

Published on: 28 August 2015
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In vivo immunogenicity of Tax (11-19) epitope in HLA-A2/DTR transgenic mice: implication for dendritic cell-based anti-HTLV-1 vaccine.

Authors: Divya Sagar, Shet Masih, Todd Schell, Steven Jacobson, Joseph D Comber, Ramila Philip, Brian Wigdahl, Pooja Jain and Zafar K Khan

Citation: Retrovirology 2015 12(Suppl 1):O28

Content type: Oral presentation

Published on: 28 August 2015
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Development of HTLV-1 associated myelopathy/tropical spastic paraparesis in a patient with simian T-lymphotropic virus type 1-like infection.

Authors: Yoshimi Enose-Akahata, Breanna Caruso, Benjamin Haner, Raya Massoud, Bridgette Jeanne Billioux, Joan Ohayon, William M Switzer and Steven Jacobson

Citation: Retrovirology 2015 12(Suppl 1):O30

Content type: Oral presentation

Published on: 28 August 2015
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A gain-of-function CCR4 mutations in adult T-cell leukemia/lymphoma (ATL) enhance the chemotactic abilities and P13K/AKT activation

Authors: Masao Nakagawa, Roland Schmitz, Wenming Xiao, Yandan Yang, Thomas A Waldmann and Louis M Staudt

Citation: Retrovirology 2015 12(Suppl 1):O31

Content type: Oral presentation

Published on: 28 August 2015
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HTLV-1-induced leukotriene B4 secretion promotes the recruitment of target cells

Authors: Florent Percher, Patricia Jeannin, Antoine Gessain, Olivier Gout, Pierre-Emmanuel Ceccaldi and Philippe V Afonso

Citation: Retrovirology 2015 12(Suppl 1):O32

Content type: Oral presentation

Published on: 28 August 2015
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Crossing of the intestinal barrier by HTLV-1 infected lymphocytes

Authors: Florent Percher, Patricia Jeannin, Pierre-Guillaume Deliège, Antoine Gessain, Aurore Vidy-Roche, Philippe V Afonso and Pierre-Emmanuel Ceccaldi

Citation: Retrovirology 2015 12(Suppl 1):O33

Content type: Oral presentation

Published on: 28 August 2015
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HTLV-1 tax hijacks cellular ubiquitination machinery to assemble K63-linked polyubiquitin for canonical NF-κB activation

Authors: Yik-Khuan A Ho, Huijun Zhi, Tara Bowlin, Batsukh Dorjbal, Subha Philip, Muhammad A Zahoor, Hsiu-Ming Shih, Brian Schaefer, JN Mark Glover and Chou-Zen Giam

Citation: Retrovirology 2015 12(Suppl 1):O34

Content type: Oral presentation

Published on: 28 August 2015
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Insight into the biogenesis of tax nuclear speckles using comparative interactome analysis

Authors: Hampus Engstrom, David J Archer, Sucharita Dutta and John O Semmes

Citation: Retrovirology 2015 12(Suppl 1):O35

Content type: Oral presentation

Published on: 28 August 2015
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IL8 Gene Polymorphism SNP rs4073 analysis between HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis and HTLV-1 Carriers

Authors: Jorge Rúa, Jason Rosado, Giovanni Lopez, Carolina Alvarez, Daniel Clark, Eduardo Gotuzzo and Michael Talledo

Citation: Retrovirology 2015 12(Suppl 1):O36

Content type: Oral presentation

Published on: 28 August 2015
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A NKG2D Thr72Ala polymorphism is not associated with HAM/TSP and proviral load values in Peruvian HTLV-1 infected patients with HAM/TSP and asymptomatic carriers

Authors: Cynthia Bernia, Jason Rosado, Giovanni López, Eduardo Gotuzzo and Michael Talledo

Citation: Retrovirology 2015 12(Suppl 1):O37

Content type: Oral presentation

Published on: 28 August 2015
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SQSTM1/p62 regulates HTLV-1 tax mediated NF-κB activation

Authors: Aurélien Schwob, Jean-Louis Palgen, Renaud Mahieux and Chloé Journo

Citation: Retrovirology 2015 12(Suppl 1):O38

Content type: Oral presentation

Published on: 28 August 2015
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Detection of HTLV-1 replication and CD4+ proliferation in the humanized BLT mouse model

Authors: Cynthia A Pise-Masison, Christopher C Nixon, Maria Fernanda de Castro Amarante, Robyn Washington Parks, Katherine McKinnon, Breanna Caruso, Veronica Galli, Steve Jacobson, Jerome Zack and Genoveffa Franchini

Citation: Retrovirology 2015 12(Suppl 1):O39

Content type: Oral presentation

Published on: 28 August 2015
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A transgenic Drosophila melanogaster model to study HTLV-I oncoprotein Tax-driven leukemogenesis in vivo

Authors: Margret Shirinian, Zakaria Kambris, Lama Hamadeh, Chloé Journo, Caroline Grabbe, Renaud Mahieux and Ali Bazarbachi

Citation: Retrovirology 2015 12(Suppl 1):O40

Content type: Oral presentation

Published on: 28 August 2015
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Anti-CCR4 antibody activates virus specific immune response in STLV-1 infected Japanese monkey

Authors: Kenji Sugata, Jun-ichirou Yasunaga, Kisato Nosaka and Masao Matsuoka

Citation: Retrovirology 2015 12(Suppl 1):O41

Content type: Oral presentation

Published on: 28 August 2015
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Selective targeting of JAK/STAT signaling is potentiated by Bcl-xL blockade in IL-2-dependent adult T-cell leukemia

Authors: Meili Zhang, Lesley A Mathews Griner, Wei Ju, Damien Y Duveau, Rajarshi Guha, Michael Petrus, Bernard Wen, Michiyuki Maeda, Paul Shinn, Marc Ferrer, Kevin C Conlon, Richard Bamford, John J O'Shea, Craig J Thomas and Thomas A Waldmann

Citation: Retrovirology 2015 12(Suppl 1):O42

Content type: Oral presentation

Published on: 28 August 2015
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Tax peptide vaccine suppressed the leukemia in humanized mouse model of ATL

Authors: Jun-ichi Fujisawa, Sung-il Lee, Jinchun Yao, Yihua Ren and Masakazu Tanaka

Citation: Retrovirology 2015 12(Suppl 1):O43

Content type: Oral presentation

Published on: 28 August 2015
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Role of myosin Va on HTLV-1 p8I protein's traffic to cell surface

Authors: Jaqueline G Jesus, Rui MPS Júnior, Maria F de Castro-Amarante, Simone K Haddad, Enilza M Espreáfico, Genoveffa Franchini and Luiz CJ Alcântara

Citation: Retrovirology 2015 12(Suppl 1):P1

Content type: Poster presentation

Published on: 28 August 2015
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Deciphering the molecular basis of arsenic/interferon-alpha induced eradication of leukemia initiating cells in adult T cell leukemia

Authors: Hiba El Hajj, Nadim Tawil, Rita Hleihel, Mark Jabbour, Ghazi Zaatari, Zafar Nawaz, Maysaloun Merhi, Edna Wang, Hideki Hasegawa, William Hall, Olivier Hermine, Hugues De Thé and Ali Bazarbachi

Citation: Retrovirology 2015 12(Suppl 1):P2

Content type: Poster presentation

Published on: 28 August 2015
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An efficient vaccine against bovine leukemia virus

Authors: Gerónimo Gutiérrez, Sabrina M Rodríguez, Agustín Vilor, Nicolas Gillet, Alix DeBrogniez, Karina Trono and Luc Willems

Citation: Retrovirology 2015 12(Suppl 1):P3

Content type: Poster presentation

Published on: 28 August 2015
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Detection and quantification of STLV-1 and SFV proviral load in blood and saliva of naturally infected non-human primates

Authors: Sandrine Alais, Amandine Pasquier, Jocelyn Turpin, Rejane Rua, Antoine Gessain, Romain Lacoste and Renaud Mahieux

Citation: Retrovirology 2015 12(Suppl 1):P4

Content type: Poster presentation

Published on: 28 August 2015
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Treatment of an aggressive STLV-1 associated lymphoma in a naturally infected baboon

Authors: Jocelyn Turpin, Sandrine Alais, Ambroise Marçais, Julie Bruneau, Anat Melamed, Nicolas Gadot, Olivier Hermine, Charles Bangham, Romain Lacoste and Renaud Mahieux

Citation: Retrovirology 2015 12(Suppl 1):P5

Content type: Poster presentation

Published on: 28 August 2015
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HTLV-1 burden dependent on hijacking monocytes chemotaxis

Authors: Maria F Castro-Amarante, Cynthia A Pise-Masison, Katherine McKinnon, Robyn W Parks, Veronica Galli, Raya Massoud, Giovanna Brunetto, Breanna Caruso, David Venzon, Steven Jacobson and Genoveffa Franchini

Citation: Retrovirology 2015 12(Suppl 1):P7

Content type: Poster presentation

Published on: 28 August 2015
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The effect of chemotherapeutics on cell-to-cell transport of HTLV-1 and the p8 protein through membrane nanotubes

Authors: M Omsland, C Pise-Masison, BT Gjertsen, G Franchini and V Andresen

Citation: Retrovirology 2015 12(Suppl 1):P8

Content type: Poster presentation

Published on: 28 August 2015
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Human bone marrow mesenchymal stromal cells exhibit suppressive effects on lymphocytes derived from HTLV-1 infected individuals

Authors: Evandra Strazza Rodrigues, Mayra Dorigan De Macedo, Katia Kaori Otaguiri, Maristela Delgado Orellana, Maurício Cristiano Rocha-Junior, Osvaldo Massaiti Takayanagui, Svetoslav Nanev Slavov, Dimas Tadeu Covas and Simone Kashima

Citation: Retrovirology 2015 12(Suppl 1):P9

Content type: Poster presentation

Published on: 28 August 2015
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The HTLV-1 latency-maintenance factor p30II activates p53-dependent metabolic effectors to promote oncogene-activation and aberrant lymphoproliferation

Authors: Robert Harrod, Megan Romeo, Aditi Malu, Tetiana Hutchison, Averi White, Rachel Gardner, Olivia Nguyen, Catherine Hazen and Neha Rao

Citation: Retrovirology 2015 12(Suppl 1):P10

Content type: Poster presentation

Published on: 28 August 2015
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17th International Conference on Human Retroviruses: HTLV and Related Viruses

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