Volume 10 Supplement 1

Frontiers of Retrovirology: Complex retroviruses, retroelements and their hosts

Meeting abstracts

This supplement has not been sponsored.

Frontiers of Retrovirology: Complex retroviruses, retroelements and their hosts.

Cambridge, UK16-18 September 2013

Concatenated PDF 10S1

Page 1 of 3

Molecular architecture of the uncleaved HIV-1 envelope glycoprotein trimer

Authors: Youdong Mao, Luis Castillo-Menendez, Liping Wang, Christopher Gu, Alon Herschhorn, Anik Désormeaux, Andres Finzi, Shi-Hua Xiang and Joseph G Sodroski

Citation: Retrovirology 2013 10(Suppl 1):O1

Content type: Oral presentation Published on: 19 September 2013
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Ubiquitin conjugation to Gag is essential for ESCRT-mediated HIV-1 budding

Authors: Paola Sette, Kunio Nagashima, Robert Piper and Fadila Bouamr

Citation: Retrovirology 2013 10(Suppl 1):O5

Content type: Oral presentation Published on: 19 September 2013
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HIV-1 RNA processing as therapeutic target: characterization of small molecule modulators of HIV-1 RNA processing and transport

Authors: Raymond Wong, Ahalya Balachandran, Matthew Haaland, Peter Stoilov and Alan Cochrane

Citation: Retrovirology 2013 10(Suppl 1):O45

Content type: Oral presentation Published on: 19 September 2013
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Autologous T-cell therapy based on a lentiviral vector expressing long antisense RNA targeted against HIV-1 env gene influences HIV replication and evolution in vivo

Authors: Alexander Pasternak, Nikolay Korokhov, Ben Berkhout, Vladimir Lukashov and Laurent Humeau

Citation: Retrovirology 2013 10(Suppl 1):O46

Content type: Oral presentation Published on: 19 September 2013
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Molecular mechanisms of the interplay between Vpx and SAMHD1

Authors: Ying Wu, Maria DeLucia, Jennifer Mehrens and Jinwoo Ahn

Citation: Retrovirology 2013 10(Suppl 1):P1

Content type: Poster presentation Published on: 19 September 2013
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The interaction of HIV-1 and HIV-2 with cellular protein trafficking pathways

Authors: Justine Alford, Robert Spooner, Michela Marongiu and Emma Anderson

Citation: Retrovirology 2013 10(Suppl 1):P2

Content type: Poster presentation Published on: 19 September 2013
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Characterisation of a spumavirus Gag protein

Authors: David C Goldstone, Thomas G Flower, Neil J Ball, Marta Sanz-Ramos, Melvin W Yap, Roksana W Ogrodowicz, Nicole Stanke, Juliane Reh, Dirk Lindemann and Jonathan P Stoye

Citation: Retrovirology 2013 10(Suppl 1):P3

Content type: Poster presentation Published on: 19 September 2013
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Identification of late assembly domains of the human endogenous retrovirus-K(HML-2)

Authors: Claudia Chudak, Nadine Beimforde, Maja George, Anja Zimmermann, Veronika Lausch, Kirsten Hanke and Norbert Bannert

Citation: Retrovirology 2013 10(Suppl 1):P4

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Replication kinetics and persistence of a conditionally live attenuated SIV (SIVrtTA) in vivo confers protection against homologous and heterologous wild-type challenge in macaques

Authors: Neil Berry, Maria Manoussaka, Claire Ham, Deborah Ferguson, Mark Page, Richard Stebbings, Atze Das, Martin Cranage, Neil Almond and Ben Berkhout

Citation: Retrovirology 2013 10(Suppl 1):P5

Content type: Poster presentation Published on: 19 September 2013
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Overview of human endogenous retroviruses found in human genome assembly GRCh37/hg19

Authors: Luana Vargiu, Patricia Rodriguez-Tomé, Göran O Sperber, Enzo Tramontano and Jonas Blomberg

Citation: Retrovirology 2013 10(Suppl 1):P6

Content type: Poster presentation Published on: 19 September 2013
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HIV-1 Nef targets calnexin: a novel mechanism behind Nef effects on host cell and viral proteins

Authors: Lucas Jennelle, Ruth Hunegnaw, Dmitri Sviridov and Michael Bukrinsky

Citation: Retrovirology 2013 10(Suppl 1):P8

Content type: Poster presentation Published on: 19 September 2013
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Identification and analysis of HML2 sequences in human genome assembly GRCh37/hg19

Authors: Marta Cadeddu, Laura Vargiu, Patricia Rodriguez-Tomé, Göran O Sperber, Jonas Blomberg and Enzo Tramontano

Citation: Retrovirology 2013 10(Suppl 1):P9

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Dissecting the contribution of Gag domain in resistance development in HIV-1 patients failing ARV therapy

Authors: Ilaria Carli, Claudia Del Vecchio, Saverio G Parisi, Federico Dal Bello, Arianna Calistri, Giorgio Palù and Cristina Parolin

Citation: Retrovirology 2013 10(Suppl 1):P10

Content type: Poster presentation Published on: 19 September 2013
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Reduction of HIV-1 infectivity by exploiting the cellular ERAD machinery

Authors: Antonio Casini, Michele Olivieri, Oscar Burrone and Anna Cereseto

Citation: Retrovirology 2013 10(Suppl 1):P11

Content type: Poster presentation Published on: 19 September 2013
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HIV-1 uncoating in human CD4⁺ T cells: kinetic and functional analyses

Authors: Nan-Yu Chen, Lihong Zhou, Paul G Gane, Amanda Price, Madeleine Zufferey, Jeremy Luban, Leo James, David Selwood and Ariberto Fassati

Citation: Retrovirology 2013 10(Suppl 1):P13

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Frequent genetic defects in long-term survivors for more than 26 years in the absence of antiretroviral therapy in Korea: its association with ginseng treatment

Authors: Young-Keol Cho, Ba-Reum Kim and Jung-Eun Kim

Citation: Retrovirology 2013 10(Suppl 1):P14

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Frequent gross deletions in pol gene in 10 HIV-1 infected patients treated with Korean red ginseng for 3 years: dosage dependency

Authors: Young-Keol Cho, Jung-Eun Kim and Ba-Reum Kim

Citation: Retrovirology 2013 10(Suppl 1):P15

Content type: Poster presentation Published on: 19 September 2013
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2-Hydroxyisoquinoline-1,3(2H, 4H)diones (HQDs), novel inhibitors of the HIV integrase catalytic activity with a high barrier to resistance

Authors: Frauke Christ, Jonas Demeulemeester, Belete Desimmie, Virginie Suchaud, Oliver Taltynov, Cedric Lion, Fabrice Bailly, Sergei Strelkov, Philipe Cotelle and Zeger Debyser

Citation: Retrovirology 2013 10(Suppl 1):P16

Content type: Poster presentation Published on: 19 September 2013
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Differential effects of Tra2β isoforms on HIV-1 RNA processing and expression

Authors: Craig Platt, Maria Calimano, Josip Nemet, Jodi Bubenik and Alan Cochrane

Citation: Retrovirology 2013 10(Suppl 1):P17

Content type: Poster presentation Published on: 19 September 2013
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Site directed mutagenesis studies on HIV-1 reverse transcriptase (RT) shed light on the mechanism of action of a new Ribonuclease H/ DNA polymerase RT dual inhibitor

Authors: Angela Corona, Rita Meleddu, Francesca Esposito, Simona Distinto, Giulia Bianco, Elias Maccioni, Stuart SF Le Grice and Enzo Tramontano

Citation: Retrovirology 2013 10(Suppl 1):P19

Content type: Poster presentation Published on: 19 September 2013
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Functional analyses of glycosylated gag molecules derived from different gammaretroviruses

Authors: Emilia Cristiana Cuccurullo, Mauro Pistello, Yasuhiro Takeuchi, Takayuki Miyazawa and Pizzato Massimo

Citation: Retrovirology 2013 10(Suppl 1):P22

Content type: Poster presentation Published on: 19 September 2013
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HIV-1 induced autophagy modulation in Langerhans cells

Authors: Magdalena Czubala, John Paul Mitchell, Fabien Blanchet and Vincent Piguet

Citation: Retrovirology 2013 10(Suppl 1):P23

Content type: Poster presentation Published on: 19 September 2013
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Characterization of microRNAs derived from the HIV-1 TAR RNA hairpin

Authors: Alex Harwig, Ben Berkhout and Atze Das

Citation: Retrovirology 2013 10(Suppl 1):P24

Content type: Poster presentation Published on: 19 September 2013
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HIV-1 interacts with human testicular germ cells in vitro

Authors: Dominique Mahé, Claire Deleage, Giulia Matusali, Anne-Pascale Satie, Karim Bensalah, Laurence Guézenec, Bernard Jégou and Nathalie Dejucq-Rainsford

Citation: Retrovirology 2013 10(Suppl 1):P26

Content type: Poster presentation Published on: 19 September 2013
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Latent HIV-1 can be reactivated by superinfection in a Tat-dependent manner, which can lead to the emergence of recombinant viruses

Authors: Daniel Aaron Donahue, Sophie M Bastarache, Richard D Sloan and Mark A Wainberg

Citation: Retrovirology 2013 10(Suppl 1):P27

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Altered expression of ligands for the NKG2D and DNAM-1 activating receptors during HIV-1 infection

Authors: Lia Vassena, Erica Giuliani, Giulia Matusali and Margherita Doria

Citation: Retrovirology 2013 10(Suppl 1):P28

Content type: Poster presentation Published on: 19 September 2013
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Genomic flexibility of human endogenous retrovirus type K

Authors: Derek Dube, Rafael Contreras-Galindo, Shirley He, Steven King, Marta Gonzalez-Hernandez, Scott Gitlin, Mark Kaplan and David Markovitz

Citation: Retrovirology 2013 10(Suppl 1):P29

Content type: Poster presentation Published on: 19 September 2013
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Targeting CCL2 inhibits viral DNA accumulation and induces APOBEC3A expression in HIV-1 infected primary human macrophages

Authors: Michela Sabbatucci, Alessandra Mallano, Cristina Purificato, Daniela Angela Covino, Maurizio Federico, Stefano Vella, Sandra Gessani, Mauro Andreotti and Laura Fantuzzi

Citation: Retrovirology 2013 10(Suppl 1):P30

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A second generation HIV-IN-EGFP fluorescent viral system to analyze HIV-1 in the nuclear compartment of infected cells

Authors: Ashwanth Christopher Francis, Cristina Di Primio, Valentina Quercioli, Annegret Boll, Daniele Arosio and Anna Cereseto

Citation: Retrovirology 2013 10(Suppl 1):P31

Content type: Poster presentation Published on: 19 September 2013
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Mapping antigenic variation in HIV-1 envelope

Authors: Simon Frost

Citation: Retrovirology 2013 10(Suppl 1):P32

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Identification of HIV-1 sequences targeted by the miRNA Induced silencing complex (miRISC) using Argonaute 2 cross-linking and immunoprecipitation (HITS-CLIP)

Authors: Agathe Eckenfelder, Natalia Pinzon Restrepo, Damien Ulveling, Jean-François Zagury, Hervé Seitz, Stéphane Emiliani and Sarah Gallois-Montbrun

Citation: Retrovirology 2013 10(Suppl 1):P33

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HIV-1 capsid interacts with cytoskeletal-associated proteins for intracytoplasmic routing to the nucleus

Authors: Juliette Fernandez, Kathleen Gärtner, Andreas Becker, Anne Danckaert, Sandie Munier, Anaba Zambo, Spencer Shorte, Yves Jacob, Pierre Charneau and Nathalie J Arhel

Citation: Retrovirology 2013 10(Suppl 1):P34

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HIV-1 replication changes the function of the PKR activator PACT

Authors: Guerline Clerzius, Eileen Shaw, Aïcha Daher, Samantha Burugu, Jean-François Gélinas, Jean-Pierre Routy, Rekha C Patel and Anne Gatignol

Citation: Retrovirology 2013 10(Suppl 1):P35

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Functional characterization of HIV-1 Nef proteins with heterologous membrane targeting signals

Authors: Miriam M Geist, Xiaoyu Pan and Oliver T Fackler

Citation: Retrovirology 2013 10(Suppl 1):P36

Content type: Poster presentation Published on: 19 September 2013
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Post transcriptional regulation of HIV-1 gene expression by MATR3, PSF and Rev

Authors: Lavina Gharu, Ania Kula, Maryana Bardina and Alessandro Marcello

Citation: Retrovirology 2013 10(Suppl 1):P37

Content type: Poster presentation Published on: 19 September 2013
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Contact-induced polarization shapes HIV-1 infected T cells for efficient HIV-1 dissemination at the virological synapse

Authors: Elisabetta Groppelli, Shimona Starling and Clare Jolly

Citation: Retrovirology 2013 10(Suppl 1):P38

Content type: Poster presentation Published on: 19 September 2013
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Human PAF1 inhibition of HIV-1

Authors: Ana Guerrero Alonso, Kelly Marno, William Ogunkolade, Julieta Diaz-Delfin, Eithne O’Sullivan and Áine McKnight

Citation: Retrovirology 2013 10(Suppl 1):P39

Content type: Poster presentation Published on: 19 September 2013
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A novel method to examine individual RNA structures within a mixed population reveals insights into the HIV-1 RNA dimerization process

Authors: Julia Kenyon, Liam Prestwood, Stuart Le Grice and Andrew Lever

Citation: Retrovirology 2013 10(Suppl 1):P41

Content type: Poster presentation Published on: 19 September 2013
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Nef variants from non-pathogenic lentiviral strains inhibit iron uptake through an AP2-dependent inhibition of transferrin endocytosis

Authors: Herwig Koppensteiner, Kristin Höhne, Marcos Vinicius Gondim, Francois-Xavier Gobert, Miriam Widder, Swantje Gundlach, Anke Heigele, Frank Kirchhoff, Michael Winkler, Philippe Benaroch and Michael Schindler

Citation: Retrovirology 2013 10(Suppl 1):P42

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Tumor suppressor proteins restricts LINE-1 retrotransposition

Authors: Misao Kuroki, Mariko Yasuda-lnoue, Shiori Nakashima and Yasuo Ariumi

Citation: Retrovirology 2013 10(Suppl 1):P43

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New host factors and pathways involved in CD4 downregulation in HIV-1 infected cells

Authors: Alessia Landi, Jolien Vermeire, Veronica Iannucci, Hanne Vanderstraeten, Evelien Naessens, Mostafa Bentahir and Bruno Verhasselt

Citation: Retrovirology 2013 10(Suppl 1):P45

Content type: Poster presentation Published on: 19 September 2013
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Novel insights from structural analysis of lentiviral and gammaretroviral reverse transcriptases in complex with RNA/DNA hybrids

Authors: Stuart Le Grice, Mikalai Lapkouski, Lan Tian, Jennifer Miller, Elzbieta Nowak, Wojciech Potrzebowski, Peter Konarev, Jason Rausch, Marion Bona, Dmitri Svergun, Janusz Bujnicki, Marcin Nowotny and Wei Yang

Citation: Retrovirology 2013 10(Suppl 1):P46

Content type: Poster presentation Published on: 19 September 2013
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The interferon-induced MxB protein inhibits an early step of HIV-1 infection

Authors: Zhenlong Liu, Qinghua Pan, Shilei Ding, Jin Qian, Fengwen Xu, Jinming Zhou, Shan Cen, Fei Guo and Chen Liang

Citation: Retrovirology 2013 10(Suppl 1):P48

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Essential domains and sequences of the foamy virus Bet protein involved in binding and counteracting APOBEC3 restriction factors

Authors: Dragana Slavkovic Lukic, Agnes Hotz-Wagenblatt and Martin Löchelt

Citation: Retrovirology 2013 10(Suppl 1):P49

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N-terminal foamy virus Gag domains and individual residues are critical for capsid assembly and interaction with the unique Env leader protein Elp for Env-dependent budding

Authors: Yang Liu and Martin Löchelt

Citation: Retrovirology 2013 10(Suppl 1):P50

Content type: Poster presentation Published on: 19 September 2013
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Characterization of human anti-V3 monoclonal antibody 904 isolated from an Indian clade C Human Immunodeficiency Virus type-1 (HIV-1) infected donor

Authors: Raiees Andrabi, Muzamil Makhdoomi and Kalpana Luthra

Citation: Retrovirology 2013 10(Suppl 1):P52

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Role of nucleoporins in nuclear import and 3D location of HIV-1 in the nuclear compartment

Authors: Ruben Maeso, Francis Ashwanth and Anna Cereseto

Citation: Retrovirology 2013 10(Suppl 1):P53

Content type: Poster presentation Published on: 19 September 2013
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Naturally-arising amino acid polymorphisms of HIV-1 Nef that differentially modulate downregulation of HLA-A and HLA-B molecules

Authors: Macdonald Mahiti, Philip Mwimanzi, Yoko Ogata, Bruce Walker, Zabrina Brumme, Mark Brockman and Takamasa Ueno

Citation: Retrovirology 2013 10(Suppl 1):P54

Content type: Poster presentation Published on: 19 September 2013
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Impact of the HIV integrase genetic context on the phenotypic expression and in vivo dynamics of integrase inhibitor resistance mutations

Authors: Nga Nguyen, Sylvie Rato, Francois Clavel, Constance Delaugerre and Fabrizio Mammano

Citation: Retrovirology 2013 10(Suppl 1):P56

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Novel restriction factor RNA-associated early-stage anti-viral factor (REAF) inhibits human and simian immunodeficiency viruses

Authors: Kelly Marno, Babatunji Ogunkolade, Corinna Pade, Nidia Oliveira, Eithne O’Sullivan and Áine McKnight

Citation: Retrovirology 2013 10(Suppl 1):P57

Content type: Poster presentation Published on: 19 September 2013
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