Volume 9 Supplement 2

AIDS Vaccine 2012

Meeting abstracts

AIDS Vaccine 2012. Go to conference site.

Boston, MA, USA9-12 September 2012

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Page 2 of 9

In vivo targeting of HIV gag to dendritic cells in combination with poly ICLC is safe and immunogenic in healthy volunteers

Authors: M Caskey, C Trumpfheller, S Pollak, L Sinnenberg, A Hurley, J Pring, I Shimeliovich, B Yipp, N Anandasabapathy, S Mehandru, P Sarma, R Koup, R Bailer, G Tomaras, A Sato, T Keler…

Citation: Retrovirology 2012 9(Suppl 2):O51

Content type: Oral presentation Published on: 13 September 2012
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First-in-human phase 1 trial of the safety and immunogenicity of a recombinant adenovirus serotype 5 HVR48 (rAd5HVR48) HIV-1 vaccine

Authors: SR Walsh, MS Seaman, JA Johnson, RP Tucker, KH Krause, M Weijtens, MG Pau, J Goudsmit, R Dolin, DH Barouch and LR Baden

Citation: Retrovirology 2012 9(Suppl 2):O52

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Antibody-mediated inhibition of HIV-1 elicited by HIV-I DNA priming and boosting with heterologous HIV-1 recombinant MVA in healthy Tanzanian adults

Authors: A Joachim, C Nilsson, S Aboud, EF Lyamuya, M Robb, M Marovich, C Ochsenbauer, B Wahren, E Sandström, G Biberfeld, G Ferrari and VR Polonis

Citation: Retrovirology 2012 9(Suppl 2):O53

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A first-in-man, double blind, placebo controlled study of the candidate therapeutic vaccine Opal-HIV-Gag(c) in HIV infected patients receiving HAART

Authors: AG Jackson, HN Kløverpris, A Handley, P Hayes, J Gilmour, M Atkins, B Walker, J Ackland, M Sullivan and P Goulder

Citation: Retrovirology 2012 9(Suppl 2):O54

Content type: Oral presentation Published on: 13 September 2012
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Multiple antibody specificities (gp41, V1V2, and V3) elicited in the phase II multiclade (A, B, C) HIV-1 DNA prime, rAd5 boost vaccine trial

Authors: WB Williams, K Jones, A Krambrink, D Grove, P Liu, NL Yates, MA Moody, G Ferrari, J Pollara, Z Moodie, CA Morgan, H Liao, DC Montefiori, C Ochsenbauer, J Kappes, S Hammer…

Citation: Retrovirology 2012 9(Suppl 2):O55

Content type: Oral presentation Published on: 13 September 2012
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Phase 2a safety and immunogenicity testing of DNA and recombinant modified vaccinia ankara virus vaccines expressing virus-like particles

Authors: P Goepfert, M Elizaga, D Montefiori, J Hural, S DeRosa, G Tomaras, K Seaton, A Sato, L Ouedraogo, Y Donastorg, M Cardinali, J Lama, L Baden, M Keefer, J McElrath, S Kalams…

Citation: Retrovirology 2012 9(Suppl 2):O56

Content type: Oral presentation Published on: 13 September 2012
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Impact of transmitted CTL escape mutations on replicative capacity and HIV pathogenesis in early infection

Authors: J Prince, D Claiborne, D Heckerman, J Carlson, H Prentice, M Schaefer, L Yue, J Mulenga, J Tang, P Goepfert, P Farmer, R Kaslow, S Allen and E Hunter

Citation: Retrovirology 2012 9(Suppl 2):O57

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A deeper view of transmitted/founder viruses using 454 whole genome deep sequencing

Authors: DC Tully, KA Power, H Bedard, CL Boutwell, P Charlebois, EM Ryan, NJ Lennon, M Altfeld, MR Henn and TM Allen

Citation: Retrovirology 2012 9(Suppl 2):O58

Content type: Oral presentation Published on: 13 September 2012
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Modeling virus exposure during male to female transmission of HIV-1

Authors: A Carias, M McRaven, M Anderson, RS Veazey and TJ Hope

Citation: Retrovirology 2012 9(Suppl 2):O59

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Beneficial HLA-mediated viral polymorphisms on the transmitted virus additively influence disease progression in HIV-1, subtype C infection

Authors: RS Ntale, DR Chopera, NK Ngandu, M Abrahams, A Debra, M Mlotswa, L Werner, Z Woodman, K Mlisana, S Abdool Karim, CM Gray and C Williamson

Citation: Retrovirology 2012 9(Suppl 2):O60

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T-cell based sieve analysis ties HLA A*02 to vaccine efficacy and IgA-C1 immune correlate in RV144 Thai trial

Authors: T Hertz, A Gartland, H Janes, S Li, Y Fong, GD Tomaras, D Morris, D Geraghty, GH Kijak, PT Edlefsen, M Rolland, BB Larsen, S Tovanabutra, E Sanders-Buell, AC DeCamp, CA Magaret…

Citation: Retrovirology 2012 9(Suppl 2):O61

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HIV-1 envelope trimer elicits higher neutralizing antibody responses than monomeric gp120

Authors: JM Kovacs, JP Nkolola, H Peng, A Cheung, J Perry, CA Miller, MS Seaman, D Barouch and B Chen

Citation: Retrovirology 2012 9(Suppl 2):O62

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Shaping humoral responses against mini-libraries of HIV env antigens via lipid nanoparticle vaccine delivery

Authors: MC Hanson, J Mata-Fink, W Abraham, KD Wittrup and DJ Irvine

Citation: Retrovirology 2012 9(Suppl 2):O63

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Vaccine responses to conserved regions of the HIV-1 proteome are associated with an increased capacity to inhibit multiple virus isolates ex vivo

Authors: A Ashraf, J Kopycinski, H Cheeseman, F Lala, J Czyzewska-Khan, A Spentzou, DK Gill, M Keefer, J Excler, P Fast, P Hayes, JH Cox and J Gilmour

Citation: Retrovirology 2012 9(Suppl 2):O64

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Antigen-specific T lymphocyte responses elicited by a DNA – MVA HIV CN54gp140 immunization regime are significantly altered by the TLR4 adjuvant GLA

Authors: PF McKay, AV Cope, J Swales, S Joseph, M Esteban, R Tatoud, D Carter, J Weber and RJ Shattock

Citation: Retrovirology 2012 9(Suppl 2):O65

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Quality of T-cell responses versus reduction in viral load: results from an exploratory phase II clinical study of Vacc-4x, a therapeutic HIV vaccine

Authors: K Ellefsen-Lavoie, J Rockstroh, R Pollard, G Pantaleo, D Podzamczer, D Asmuth, J van Lunzen, K Arastéh, D Schürmann, B Peters, B Clotet, D Hardy, A Lazzarin, J Gatell, MA Sommerfelt, I Baksaas…

Citation: Retrovirology 2012 9(Suppl 2):O66

Content type: Oral presentation Published on: 13 September 2012
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DNA vaccines expressing conserved elements provide potent and broad immune responses

Authors: GN Pavlakis, V Kulkarni, A Valentin, M Rosati, NY Sardesai, B Mothe, C Brander, S LeGall, DB Weiner, M Rolland, JI Mullins and BK Felber

Citation: Retrovirology 2012 9(Suppl 2):O67

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Reinventing the nucleic acid vaccine with self-amplifying RNA

Authors: AJ Geall, GR Otten, A Hekele, W Bogers, H Oostermeijer, P Mooij, K Gerrit, E Verschoor, K Banerjee, Y Cu, CW Beard, LA Brito, JB Ulmer, CW Mandl and SW Barnett

Citation: Retrovirology 2012 9(Suppl 2):O68

Content type: Oral presentation Published on: 13 September 2012
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Adenovirus serotype 26 utilizes CD46 as primary cellular receptor and only transiently activates T lymphocytes following vaccination of rhesus monkeys

Authors: H Li, EG Rhee, K Masek-Hammerman, JE Teigler, P Abbink and DH Barouch

Citation: Retrovirology 2012 9(Suppl 2):O69

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Full-length HIV-1 immunogens induce greater T lymphocyte responses to conserved epitopes than conserved-region-only HIV-1 immunogens in monkeys

Authors: KE Stephenson, A SanMiguel, NL Simmons, K Smith, JJ Szinger, BT Korber and DH Barouch

Citation: Retrovirology 2012 9(Suppl 2):O70

Content type: Oral presentation Published on: 13 September 2012
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Rational immunogen design to target specific germline B cell receptors

Authors: J Jardine, O Kalyuzhniy, T Ota, A McGuire, S Menis, J Julien, E Falkowska, S MacPherson, M Jones, DR Burton, IA Wilson, L Stamatatos, D Nemazee and WR Schief

Citation: Retrovirology 2012 9(Suppl 2):O71

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rAd5 prime/NYVAC-B boost regimen is superior to NYVAC-B prime/rAd5 boost regimen for both response rates and magnitude of CD4 and CD8 T-cell responses

Authors: P Bart, Y Huang, N Frahm, S Karuna, M Allen, NK Kochar, S Chappuis, J Gaillard, B Graham and G Pantaleo

Citation: Retrovirology 2012 9(Suppl 2):O72

Content type: Oral presentation Published on: 13 September 2012
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Live, attenuated rubella vectors expressing HIV and SIV vaccine antigens

Authors: I Berkower, Y Ni and K Virnik

Citation: Retrovirology 2012 9(Suppl 2):P1

Content type: Poster presentation Published on: 13 September 2012
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HIV-1 capture and antigen presentation by dendritic cells: enhanced viral capture does not correlate with better T-Cell activation

Authors: M Rodriguez-Plata, A Urrutia, S Cardinaud, M Buzon, N Izquierdo-Useros, JG Prado, M Puertas, I Erkizia, P Coulon, S Cedeño, B Clotet, A Moris and J Martinez-Picado

Citation: Retrovirology 2012 9(Suppl 2):P2

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CYPA, a novel and potential genetic adjuvant enhanced HIV-1 DNA vaccine immunoreactivity

Authors: J Hou, Y Liu and Y Shao

Citation: Retrovirology 2012 9(Suppl 2):P3

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Cross-clade neutralization of HIV-1 by a monoclonal antibody obtained by immunization with liposomes containing lipid A and a synthetic MPER peptide

Authors: GR Matyas, O Jobe, L Wieczorek, KK Peachman, Z Beck, VR Polonis, M Rao and CR Alving

Citation: Retrovirology 2012 9(Suppl 2):P4

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IL-12 plus CTB in intranasal DNA-MVA schemes improved magnitude and quality of both systemic and mucosal HIV cellular immune responses

Authors: AM Rodriguez, C Maeto, J Falivene, MP Holgado and MM Gherardi

Citation: Retrovirology 2012 9(Suppl 2):P5

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Engineered gp120 immunogens that elicit VRC01-like antibodies by vaccination

Authors: J Mata-Fink, M Hanson, B Kriegsman, D Irvine and K Wittrup

Citation: Retrovirology 2012 9(Suppl 2):P6

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TLR-3 and TLR-7/8 ligands indirectly activate Langerhans cells when intradermally injected by triggering the recruitment of inflammatory cells

Authors: O Epaulard, L Adam, R Le Grand and F Martinon

Citation: Retrovirology 2012 9(Suppl 2):P7

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Fusion of CTA and CTB gene to immunogen significantly enhances the immunogenicity of DNA vaccine

Authors: X Ren, Y Wan, X Xie and J Xu

Citation: Retrovirology 2012 9(Suppl 2):P8

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HIV-1 gp120 impairs the induction of B cell responses by TLR9-activated plasmacytoid dendritic cells

Authors: NP Chung, K Matthews, RW Sanders and JP Moore

Citation: Retrovirology 2012 9(Suppl 2):P9

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Soluble and bacteriophage T4 displayed gp41 mutant proteins as HIV-1 vaccine candidates

Authors: G Gao, KK Peachman, L Wieczorek, V Polonis, CR Alving, M Rao and VB Rao

Citation: Retrovirology 2012 9(Suppl 2):P10

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Evaluation of Latent Membrane Protein 1 as a novel vaccine adjuvant

Authors: JM Termini, S Gupta and GW Stone

Citation: Retrovirology 2012 9(Suppl 2):P11

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Potent induction of antibody-secreting B-cells by human dermal-derived CD14+ dendritic cells triggered by dual toll-like receptor ligation

Authors: K Matthews, NP Chung, PJ Klasse, JP Moore and RW Sanders

Citation: Retrovirology 2012 9(Suppl 2):P12

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Recombinant IL-21 induces perforin and granzyme B in total and virus specific CD8 Tcells in acute and early stages of SIV infection in rhesus macaques

Authors: S Pallikkuth, L Micci, Z Ende, K Rogers, G Silvestry, F Villinger, M Paiardini and S Pahwa

Citation: Retrovirology 2012 9(Suppl 2):P13

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Inverse dose-response to gp140 YU2 foldon trimer formulated with aluminum phosphate and ISCOMATRIX® adjuvants

Authors: A Wilson, R Powell, S Hoffenberg, A Carpov, H Arendt, J DeStefano and MJ Caulfield

Citation: Retrovirology 2012 9(Suppl 2):P14

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Robust antibody and cellular responses with an improved DNA vaccine alone

Authors: N Hutnick, DJ Myles, K Muthumani, M Morrow, J Yan, AS Khan, NY Sardasai and DB Weiner

Citation: Retrovirology 2012 9(Suppl 2):P15

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Adjuvant-dependent cytokine profiles in the context of a DNA prime-protein boost HIV-1 vaccine

Authors: R Buglione-Corbett, K Pouliot, R Marty-Roix, K West, S Wang, E Lien and S Lu

Citation: Retrovirology 2012 9(Suppl 2):P16

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Neutralizing antibodies elicited in rabbits by patient-derived Env trimer immunization

Authors: L Heyndrickx, G Stewart-Jones, H Schuitemaker, E Bowles, L Buonaguro, M Jansson, B Grevstad, L Vinner, M Ramaswamy, P Biswas, G Scarlatti, G Vanham and A Fomsgaard

Citation: Retrovirology 2012 9(Suppl 2):P17

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Rationally designed HIV envelope glycoproteins delivered in a novel adjuvant elicited more broadly reactive antigen-specific antibody responses

Authors: AK Dey, A Kassa, A Nandi, Y Sun, C Labranche, K Hartog, D Montefiori, A Carfi, I Srivastava and SW Barnett

Citation: Retrovirology 2012 9(Suppl 2):P18

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CCL28 induces mucosal homing of HIV-1-specific IgA-secreting plasma cells in mice immunized with HIV-1 Virus-like Particles

Authors: V Rainone, G Dubois, V Temchura, K Uberla, M Nebuloni, E Lauri, D Trabattoni, F Veas and M Clerici

Citation: Retrovirology 2012 9(Suppl 2):P19

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NMR spectroscopy of HIV-1 gp120 outer domain

Authors: M Sastry, L Xu, S Bhattacharya, GJ Nabel, CA Bewley and PD Kwong

Citation: Retrovirology 2012 9(Suppl 2):P20

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Immunogenicity of native and CD4 liganded monomeric and trimeric envelope glycoproteins based on HIV-1 Subtype C consensus Founder virus sequences

Authors: MA Killick, A Capovilla and MA Papathanasopoulos

Citation: Retrovirology 2012 9(Suppl 2):P21

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Multivalent adenoviral vectors which use an antigen capsid-incorporation strategy for HIV vaccination

Authors: L Gu, ZC Li, V Krendelchtchikova, A Krendelchtchikov and QL Matthews

Citation: Retrovirology 2012 9(Suppl 2):P22

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Hyperglycosylated resurfaced stabilized GP120 core as an immunogen elicits antibodies targeted at the CD4-binding site

Authors: K Dai, JC Boyington, W Shi, SD Schmidt, I Georgiev, D Lingwood, PD Kwong, JR Mascola, Z Yang and GJ Nabel

Citation: Retrovirology 2012 9(Suppl 2):P23

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Macaques primed with self-amplifying RNA vaccines expressing HIV-1 envelope and boosted with recombinant protein show potent T- and B-cell responses

Authors: WM Bogers, H Oostermeijer, P Mooij, G Koopman, E Verschoor, D Davis, JL Heeney, Y Cu, K Banerjee, B Burke, A Dey, A Geall and SW Barnett

Citation: Retrovirology 2012 9(Suppl 2):P24

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GM-CSF co-expressing DNA/MVA vaccine, prevention of acquisition by two series of SIVE660 challenges followed by a series of SIV251 challenges

Authors: H Robinson, S Kannanganat, S Gangadhara, L Lai, T Yu, P Kozlowski, P Earl, B Moss and RR Amara

Citation: Retrovirology 2012 9(Suppl 2):P25

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Efficacy of vaccine-induced Vif-specific CTL responses against SIVmac239 infection: implications for antigen design in AIDS vaccines

Authors: N Iwamoto, N Takahashi, T Nomura, H Yamamoto and T Matano

Citation: Retrovirology 2012 9(Suppl 2):P26

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Induction of HIV-1 Gag-specific memory T cells in Chacma baboons by MVA prime and VLP boost vaccine regimen

Authors: V Singh, G Chege, E Shephard and A Williamson

Citation: Retrovirology 2012 9(Suppl 2):P27

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Construction of SHIVs expressing quaternary neutralization epitopes in Env and mimicking the neutralization phenotype of typical HIV-1 isolates

Authors: JF Theis, A de Parseval, WJ Honnen, A Phogat, UC Ganapathi, Z Lai, L Peng, C Reichman, PL Moore, L Morris, Y Li, S Hu and A Pinter

Citation: Retrovirology 2012 9(Suppl 2):P28

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