Open Access

Erratum to: Are T cells the only HIV-1 reservoir?

  • Abraham Joseph Kandathil1,
  • Sho Sugawara1 and
  • Ashwin Balagopal1Email author
Retrovirology201714:11

https://doi.org/10.1186/s12977-017-0333-x

Published: 8 February 2017

The original article was published in Retrovirology 2016 13:86

Erratum to: Retrovirology (2016) 13:86 DOI 10.1186/s12977-016-0323-4

Unfortunately, the original version of this article [1] contained an error. Table 1 has errors with the references. The correct Table 1 is found below.
Table 1

Summary data on HIV-1 reservoirs and assays in various cell populations

 

Memory CD4+T cells

Myeloid cells

Dendritic cells

FDCs

Epithelial cells

Monocytes

Macrophages

pDCs

mDCs

Available VOA?

Yes (gold standard) [112]

Yes [24]

Yes [25]

No

No

Yes [87]

No

Has VOA been applied to PLWH taking long-term ART?

Yes (gold standard) [18]

No [24]

Yes [25]

NA

NA

Yes [87]

No

Has HIV-1 been demonstrated in the indicated cell type in PLWH taking long-term ART?

Yes (gold standard) [18]

No [24]

Yes [25]

NA

NA

Yes [87]

Yes [98, 99]

Is HIV in this reservoir replication competent?

Yes (gold standard) [18]

NA

No

NA

NA

Yes [87]

NA

Available animal models?

Yes [124]

Yes [24, 58]

Yes [24, 58]

Yes [130]

Yes [130]

Yes [85]

No

Have animal models been studied during long-term ART?

Yes [138]

No

No

No

No

No

No

Do animal models with suppressed viremia contain replication competent HIV-1?

Yes [138]

NA

NA

NA

NA

NA

NA

Longevity or T½ of uninfected cells

1–12 months [29, 30]a

2–3 days [31]

≥24–36 months [32]b

?

?

?

?

Longevity or T½ of reservoir in this cell type

44 months [18]a

NA

?

?

?

9 months [85]c

?

? Not known, NA not applicable

aThere are discrepant data on the longevity of uninfected memory CD4+T cells and latent HIV-1 reservoirs therein. However, it is difficult to accurately estimate the T½ of HIV-1 infected T cells due to possible clonal proliferation: i.e., the listed T½ describes the duration of the HIV-1 reservoir itself, but does not directly address the T½ of the cell that harbors the reservoir

bIn the described experiments, donor alveolar macrophages were found 2–3 years after lung transplantation in human subjects: while we assume that these TRM persisted for this duration, it is possible that they underwent proliferation and replacement locally

cThe indicated longevity is for the infectious virions that were found on FDC dendrites, although it is controversial whether this cell type was actually infected

138 Dinoso JB, Rabi SA, Blankson JN, Gama L, Mankowski JL, Siliciano RF, Zink MC, Clements JE. A simian immunodeficiency virus-infected macaque model to study viral reservoirs that persist during highly active antiretroviral therapy. J Virol. 2009;83(18):9247–57

Notes

Declarations

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Authors’ Affiliations

(1)
Department of Medicine, Johns Hopkins University Baltimore

Reference

  1. Kandathil AJ, Sugawara S, Balagopal A. Are T cells the only HIV-1 reservoir? Retrovirology. 2016;13:86. doi:10.1186/s12977-016-0323-4.View ArticlePubMedPubMed CentralGoogle Scholar

Copyright

© The Author(s) 2017

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