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  2. Since the discovery of human immunodeficiency virus (HIV-1) twenty years ago, AIDS has become one of the most studied diseases. A number of viruses have subsequently been identified to contribute to the pathog...

    Authors: Elodie Ghedin, Anne Pumfery, Cynthia de la Fuente, Karen Yao, Naomi Miller, Vincent Lacoste, John Quackenbush, Steven Jacobson and Fatah Kashanchi
    Citation: Retrovirology 2004 1:10
    Content type: Research Published on:

  3. During the last two decades, the profusion of HIV research due to the urge to identify new therapeutic targets has led to a wealth of information on the retroviral replication cycle. However, while the late st...

    Authors: Sébastien Nisole and Ali Saïb
    Citation: Retrovirology 2004 1:9
    Content type: Review Published on:

  4. Recent data have established the HIV-1 and SIV escape CTL through epitope mutation. However, three novel studies prove that such escape comes at a "cost" to overall viral fitness. Understanding how HIV-1/SIV e...

    Authors: Stephen M Smith
    Citation: Retrovirology 2004 1:8
    Content type: Commentary Published on:

  5. It is poorly understood why many transforming proteins reportedly enhance both cell growth (transformation) and cell death (apoptosis). At first glance, the ability to transform and the ability to engender apo...

    Authors: Takefumi Kasai and Kuan-Teh Jeang
    Citation: Retrovirology 2004 1:7
    Content type: Research Published on:

  6. The human T-cell leukemia virus type 1 (HTLV-1) Tax protein indirectly influences transcriptional activation, signal transduction, cell cycle control, and apoptosis. The function of Tax primarily relies on pro...

    Authors: Kylene Kehn, Longwen Deng, Cynthia de la Fuente, Katharine Strouss, Kaili Wu, Anil Maddukuri, Shanese Baylor, Robyn Rufner, Anne Pumfery, Maria Elena Bottazzi and Fatah Kashanchi
    Citation: Retrovirology 2004 1:6
    Content type: Research Published on:

  7. To generate a replication-competent retrovirus that could be conditionally inactivated, we flanked the viral genes of the Akv murine leukemia virus with LoxP sites. This provirus can delete its envelope gene b...

    Authors: Clifford L Wang, J Graeme Hodgson, Tiffany Malek, Finn Skou Pedersen and Matthias Wabl
    Citation: Retrovirology 2004 1:5
    Content type: Research Published on:

  8. HTLV-I is associated with adult T-cell leukemia, and both HTLV-I and -II are associated with HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Several published reports suggest that HTLV-I may...

    Authors: Jennie R Orland, Baoguang Wang, David J Wright, Catharie C Nass, George Garratty, James W Smith, Bruce Newman, Donna M Smith and Edward L Murphy
    Citation: Retrovirology 2004 1:4
    Content type: Research Published on:

  9. We previously described the construction of an HIV-1 envelope glycoprotein complex (Env) that is stabilized by an engineered intermolecular disulfide bond (SOS) between gp120 and gp41. The modified Env protein...

    Authors: Rogier W Sanders, Martijn M Dankers, Els Busser, Michael Caffrey, John P Moore and Ben Berkhout
    Citation: Retrovirology 2004 1:3
    Content type: Research Published on:

  10. CCR5 and CXCR4 are the two main coreceptors essential for HIV entry. Therefore, these chemokine receptors have become important targets in the search for anti-HIV agents. Here, we describe the establishment of...

    Authors: Katrien Princen, Sigrid Hatse, Kurt Vermeire, Erik De Clercq and Dominique Schols
    Citation: Retrovirology 2004 1:2
    Content type: Research Published on:
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Retrovirology

ISSN: 1742-4690

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