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  1. It is poorly understood why many transforming proteins reportedly enhance both cell growth (transformation) and cell death (apoptosis). At first glance, the ability to transform and the ability to engender apo...

    Authors: Takefumi Kasai and Kuan-Teh Jeang
    Citation: Retrovirology 2004 1:7
  2. The human T-cell leukemia virus type 1 (HTLV-1) Tax protein indirectly influences transcriptional activation, signal transduction, cell cycle control, and apoptosis. The function of Tax primarily relies on pro...

    Authors: Kylene Kehn, Longwen Deng, Cynthia de la Fuente, Katharine Strouss, Kaili Wu, Anil Maddukuri, Shanese Baylor, Robyn Rufner, Anne Pumfery, Maria Elena Bottazzi and Fatah Kashanchi
    Citation: Retrovirology 2004 1:6
  3. To generate a replication-competent retrovirus that could be conditionally inactivated, we flanked the viral genes of the Akv murine leukemia virus with LoxP sites. This provirus can delete its envelope gene b...

    Authors: Clifford L Wang, J Graeme Hodgson, Tiffany Malek, Finn Skou Pedersen and Matthias Wabl
    Citation: Retrovirology 2004 1:5
  4. HTLV-I is associated with adult T-cell leukemia, and both HTLV-I and -II are associated with HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Several published reports suggest that HTLV-I may...

    Authors: Jennie R Orland, Baoguang Wang, David J Wright, Catharie C Nass, George Garratty, James W Smith, Bruce Newman, Donna M Smith and Edward L Murphy
    Citation: Retrovirology 2004 1:4
  5. We previously described the construction of an HIV-1 envelope glycoprotein complex (Env) that is stabilized by an engineered intermolecular disulfide bond (SOS) between gp120 and gp41. The modified Env protein...

    Authors: Rogier W Sanders, Martijn M Dankers, Els Busser, Michael Caffrey, John P Moore and Ben Berkhout
    Citation: Retrovirology 2004 1:3
  6. CCR5 and CXCR4 are the two main coreceptors essential for HIV entry. Therefore, these chemokine receptors have become important targets in the search for anti-HIV agents. Here, we describe the establishment of...

    Authors: Katrien Princen, Sigrid Hatse, Kurt Vermeire, Erik De Clercq and Dominique Schols
    Citation: Retrovirology 2004 1:2

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