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  1. The HIV-1 genome encodes a well-conserved accessory gene product, Vpr, that serves multiple functions in the retroviral life cycle, including the enhancement of viral replication in nondividing macrophages, th...

    Authors: Xiao-Jian Yao, Nicole Rougeau, Ghislaine Duisit, Julie Lemay and Éric A Cohen
    Citation: Retrovirology 2004 1:21
  2. The viral transactivator of HTLV-I, Tax, has long been shown to target the earliest steps of transcription by forming quaternary complexes with sequence specific transcription factors and histone-modifying enz...

    Authors: Cynthia de la Fuente and Fatah Kashanchi
    Citation: Retrovirology 2004 1:19
  3. Human T-cell leukemia virus type I (HTLV-I) Tax protein is a transcriptional regulator of viral and cellular genes. In this study we have examined in detail the determinants for Tax-mediated transcriptional ac...

    Authors: Yick-Pang Ching, Abel CS Chun, King-Tung Chin, Zhi-Qing Zhang, Kuan-Teh Jeang and Dong-Yan Jin
    Citation: Retrovirology 2004 1:18
  4. The viral and host factors involved in transmission of HIV through breastfeeding are largely unknown, and intervention strategies are urgently needed to protect at-risk populations. To evaluate the viral and i...

    Authors: Angela M Amedee, Jenna Rychert, Nedra Lacour, Lynn Fresh and Marion Ratterree
    Citation: Retrovirology 2004 1:17
  5. The HIV-1 plague continues unabatedly across sub-Saharan Africa. In Botswana and Swaziland, nearly 40% of the entire adult population is already infected. No current program is capable of slowing the advancing...

    Authors: Stephen M Smith
    Citation: Retrovirology 2004 1:16
  6. Despite the effectiveness of currently available antiretroviral therapies in the treatment of HIV-1 infection, a continuing need exists for novel compounds that can be used in combination with existing drugs t...

    Authors: Jing Zhou, Chin Ho Chen and Christopher Aiken
    Citation: Retrovirology 2004 1:15
  7. Apoptosis, or programmed cell death, is a key event in biologic homeostasis but is also involved in the pathogenesis of many human diseases including human immunodeficiency virus (HIV) infection. Although mult...

    Authors: Barbara Ahr, Véronique Robert-Hebmann, Christian Devaux and Martine Biard-Piechaczyk
    Citation: Retrovirology 2004 1:12
  8. Since the discovery of human immunodeficiency virus (HIV-1) twenty years ago, AIDS has become one of the most studied diseases. A number of viruses have subsequently been identified to contribute to the pathog...

    Authors: Elodie Ghedin, Anne Pumfery, Cynthia de la Fuente, Karen Yao, Naomi Miller, Vincent Lacoste, John Quackenbush, Steven Jacobson and Fatah Kashanchi
    Citation: Retrovirology 2004 1:10
  9. During the last two decades, the profusion of HIV research due to the urge to identify new therapeutic targets has led to a wealth of information on the retroviral replication cycle. However, while the late st...

    Authors: Sébastien Nisole and Ali Saïb
    Citation: Retrovirology 2004 1:9
  10. Recent data have established the HIV-1 and SIV escape CTL through epitope mutation. However, three novel studies prove that such escape comes at a "cost" to overall viral fitness. Understanding how HIV-1/SIV e...

    Authors: Stephen M Smith
    Citation: Retrovirology 2004 1:8
  11. It is poorly understood why many transforming proteins reportedly enhance both cell growth (transformation) and cell death (apoptosis). At first glance, the ability to transform and the ability to engender apo...

    Authors: Takefumi Kasai and Kuan-Teh Jeang
    Citation: Retrovirology 2004 1:7
  12. The human T-cell leukemia virus type 1 (HTLV-1) Tax protein indirectly influences transcriptional activation, signal transduction, cell cycle control, and apoptosis. The function of Tax primarily relies on pro...

    Authors: Kylene Kehn, Longwen Deng, Cynthia de la Fuente, Katharine Strouss, Kaili Wu, Anil Maddukuri, Shanese Baylor, Robyn Rufner, Anne Pumfery, Maria Elena Bottazzi and Fatah Kashanchi
    Citation: Retrovirology 2004 1:6
  13. To generate a replication-competent retrovirus that could be conditionally inactivated, we flanked the viral genes of the Akv murine leukemia virus with LoxP sites. This provirus can delete its envelope gene b...

    Authors: Clifford L Wang, J Graeme Hodgson, Tiffany Malek, Finn Skou Pedersen and Matthias Wabl
    Citation: Retrovirology 2004 1:5
  14. HTLV-I is associated with adult T-cell leukemia, and both HTLV-I and -II are associated with HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Several published reports suggest that HTLV-I may...

    Authors: Jennie R Orland, Baoguang Wang, David J Wright, Catharie C Nass, George Garratty, James W Smith, Bruce Newman, Donna M Smith and Edward L Murphy
    Citation: Retrovirology 2004 1:4
  15. We previously described the construction of an HIV-1 envelope glycoprotein complex (Env) that is stabilized by an engineered intermolecular disulfide bond (SOS) between gp120 and gp41. The modified Env protein...

    Authors: Rogier W Sanders, Martijn M Dankers, Els Busser, Michael Caffrey, John P Moore and Ben Berkhout
    Citation: Retrovirology 2004 1:3
  16. CCR5 and CXCR4 are the two main coreceptors essential for HIV entry. Therefore, these chemokine receptors have become important targets in the search for anti-HIV agents. Here, we describe the establishment of...

    Authors: Katrien Princen, Sigrid Hatse, Kurt Vermeire, Erik De Clercq and Dominique Schols
    Citation: Retrovirology 2004 1:2

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