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  1. The persistence of latent HIV-1 reservoirs is the principal barrier preventing the eradication of HIV-1 infection in patients by current antiretroviral therapy. It is thus crucial to understand the molecular m...

    Authors: Sandie Munier, Delphine Delcroix-Genête, Laëtitia Carthagéna, Audrey Gumez and Uriel Hazan
    Citation: Retrovirology 2005 2:73
  2. Every year the Cancer Research Institute from University of California at Irvine organizes the West Coast Retrovirus Meeting where participants have a chance to discuss the latest progress in understanding the...

    Authors: Sheila M Barry, Marta Melar, Philippe Gallay and Thomas J Hope
    Citation: Retrovirology 2005 2:72
  3. Human T-cell leukemia virus type 1 and type 2 are related human retroviruses. HTLV-1 is the etiological agent of the Adult T-cell Leukemia/Lymphoma and of the Tropical Spastic Paraparesis/HTLV-1 Associated Mye...

    Authors: Sébastien A Chevalier, Laurent Meertens, Sara Calattini, Antoine Gessain, Lars Kiemer and Renaud Mahieux
    Citation: Retrovirology 2005 2:70
  4. Human immunodeficiency virus type 1 (HIV-1) Tat transactivation is an essential step in the viral life cycle. Over the past several years, it has become widely accepted that Tat exerts its transcriptional effe...

    Authors: John Brady and Fatah Kashanchi
    Citation: Retrovirology 2005 2:69
  5. Given the high prevalence of mother to child infection, the development of a better understanding of African subtype C HIV-1 transmission and natural evolution is of significant importance. In this study, we g...

    Authors: Hong Zhang, Federico Hoffmann, Jun He, Xiang He, Chipepo Kankasa, Ruth Ruprecht, John T West, Guillermo Orti and Charles Wood
    Citation: Retrovirology 2005 2:67
  6. We have examined the kinetics of processing of the HIV-1 Gag-Pro-Pol precursor in an in vitro assay with mature protease added in trans. The processing sites were cleaved at different rates to produce distinct...

    Authors: Steve C Pettit, Jeffrey N Lindquist, Andrew H Kaplan and Ronald Swanstrom
    Citation: Retrovirology 2005 2:66
  7. Increasing evidence indicates that RNA interference (RNAi) may be used to provide antiviral immunity in mammalian cells. Human micro (mi)RNAs can inhibit the replication of a primate virus, whereas a virally-e...

    Authors: Anne Gatignol, Sébastien Lainé and Guerline Clerzius
    Citation: Retrovirology 2005 2:65
  8. Human T-cell leukemia virus type I (HTLV-I) causes adult T-cell leukemia (ATL) after a long latent period. Among accessory genes encoded by HTLV-I, the tax gene is thought to play a central role in oncogenesis. H...

    Authors: Yuko Taniguchi, Kisato Nosaka, Jun-ichirou Yasunaga, Michiyuki Maeda, Nancy Mueller, Akihiko Okayama and Masao Matsuoka
    Citation: Retrovirology 2005 2:64
  9. HIV-1 and all retroviruses are related to retroelements of simpler organisms such as the yeast Ty elements. Recent work has suggested that the yeast retroelement Ty1 replicates via an unexpected RNA lariat int...

    Authors: Ying Ye, Jessica De Leon, Noriko Yokoyama, Yathi Naidu and David Camerini
    Citation: Retrovirology 2005 2:63
  10. In addition to mediating the integration process, HIV-1 integrase (IN) has also been implicated in different steps during viral life cycle including reverse transcription and viral DNA nuclear import. Although...

    Authors: Zhujun Ao, Keith R Fowke, Éric A Cohen and Xiaojian Yao
    Citation: Retrovirology 2005 2:62

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