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  1. The HTLV-1 Tax oncoprotein rapidly induces cytogenetic damage which can be measured by a significant increase in the number of micronuclei (MN) in cells. Tax is thought to have both aneuploidogenic and clastog...

    Authors: Franca Majone, Roberto Luisetto, Daniela Zamboni, Yoichi Iwanaga and Kuan-Teh Jeang

    Citation: Retrovirology 2005 2:45

    Content type: Research

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  2. We determined the relative ratios of Gag and Pol molecules in highly purified virions of spumaretroviruses or foamy viruses (FVs) using monoclonal antibodies and bacterially expressed reference proteins. We fo...

    Authors: Marc Cartellieri, Wolfram Rudolph, Ottmar Herchenröder, Dirk Lindemann and Axel Rethwilm

    Citation: Retrovirology 2005 2:44

    Content type: Short report

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  3. The positive transcription elongation factor b (P-TEFb) composed by CDK9/CyclinT1 subunits is a dedicated co-factor of HIV transcriptional transactivator Tat protein. Transcription driven by the long terminal ...

    Authors: Alessandro Fraldi, Francesca Varrone, Giuliana Napolitano, Annemieke A Michels, Barbara Majello, Olivier Bensaude and Luigi Lania

    Citation: Retrovirology 2005 2:42

    Content type: Research

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  4. The actual relationship between viral variability and HIV disease progression and/or non-progression can only be extrapolated through epidemiologically-linked HIV-infected cohorts. The rarity of such cohorts a...

    Authors: Meriet Mikhail, Bin Wang, Philippe Lemey, Brenda Beckthold, Anne-Mieke Vandamme, M John Gill and Nitin K Saksena

    Citation: Retrovirology 2005 2:41

    Content type: Research

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  5. GBV-C virus infection has been linked to improved clinical outcome in HIV-1 co-infected individuals. The epidemiology of GBV-C has, thus far, been limited to the gay male, HIV+ population. Here we describe the pr...

    Authors: Stephen M Smith, Michael J Donio, Mahender Singh, James P Fallon, Lavanya Jitendranath, Natalia Chkrebtii, Jihad Slim, Diana Finkel and George Perez

    Citation: Retrovirology 2005 2:38

    Content type: Research

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  6. APOBEC3G is a cellular cytidine deaminase that was recently identified as the Vif-sensitive antiviral host factor responsible for the restriction of vif-defective HIV-1 in primary human cells and certain non-perm...

    Authors: Klaus Strebel

    Citation: Retrovirology 2005 2:37

    Content type: Commentary

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  7. The reverse transcriptase (RT) enzyme of human immunodeficiency virus type 1 (HIV-1) plays a crucial role in the life cycle of the virus by converting the single stranded RNA genome into double stranded DNA th...

    Authors: Vasudha Sundaravaradan, Tobias Hahn and Nafees Ahmad

    Citation: Retrovirology 2005 2:36

    Content type: Research

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  8. Apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3G (APOBEC3G) is a host cellular protein with a broad antiviral activity. It inhibits infectivitiy of a wide variety of retroviruses by deaminati...

    Authors: Amane Sasada, Akifumi Takaori-Kondo, Kotaro Shirakawa, Masayuki Kobayashi, Aierkin Abudu, Masakatsu Hishizawa, Kazunori Imada, Yuetsu Tanaka and Takashi Uchiyama

    Citation: Retrovirology 2005 2:32

    Content type: Research

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  9. Retroviral integration is central to viral persistence and pathogenesis, cancer as well as host genome evolution. However, it is unclear why integration appears essential for retrovirus production, especially ...

    Authors: Olivier Delelis, Caroline Petit, Herve Leh, Gladys Mbemba, Jean-François Mouscadet and Pierre Sonigo

    Citation: Retrovirology 2005 2:31

    Content type: Research

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  10. Human T-cell Leukemia virus type 1 (HTLV-1) and type 2 (HTLV-2) are pathogenic retroviruses that infect humans and cause severe hematological and neurological diseases. Both viruses have simian counterparts (S...

    Authors: Sara Calattini, Sébastien Alain Chevalier, Renan Duprez, Sylviane Bassot, Alain Froment, Renaud Mahieux and Antoine Gessain

    Citation: Retrovirology 2005 2:30

    Content type: Short report

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  11. Human T-cell leukemia virus type 1 (HTLV-1) is associated with the development of adult T-cell leukemia (ATL). HTLV-1 encoded Tax1 oncoprotein activates the transcription of genes involved in cell growth and a...

    Authors: Masaya Higuchi, Takehiro Matsuda, Naoki Mori, Yasuaki Yamada, Ryouichi Horie, Toshiki Watanabe, Masahiko Takahashi, Masayasu Oie and Masahiro Fujii

    Citation: Retrovirology 2005 2:29

    Content type: Research

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  12. Reducing transmission of HIV-1 through breast milk is needed to help decrease the burden of pediatric HIV/AIDS in society. We have previously reported that alkyl sulfates (i.e., sodium dodecyl sulfate, SDS) ar...

    Authors: Sandra Urdaneta, Brian Wigdahl, Elizabeth B Neely, Cheston M Berlin Jr, Cara-Lynne Schengrund, Hung-Mo Lin and Mary K Howett

    Citation: Retrovirology 2005 2:28

    Content type: Research

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  13. The first Dominique Dormont International Conference on "Viral and host determinantsof HCV, HCMV, and HIV infections "was held in Paris, Val-de-Grâce, on December 3–4, 2004. The following is a summary of the s...

    Authors: Elisabeth Menu, Mickaela C Müller-Trutwin, Gianfranco Pancino, Asier Saez-Cirion, Christine Bain, Geneviève Inchauspé, Gabriel S Gras, Aloïse M Mabondzo, Assia Samri, Françoise Boutboul and Roger Le Grand

    Citation: Retrovirology 2005 2:24

    Content type: Review

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  14. Human T-lymphotropic virus type 1 (HTLV-1) and HTLV-2 were among the first human retroviruses discovered in the early 1980's. The International Retrovirology Association is an organized effort that fostered th...

    Authors: Edward Murphy, Steven Jacobson, Genoveffa Franchini, Graham P Taylor, Barrie Hanchard, Owen Morgan and Michael Lairmore

    Citation: Retrovirology 2005 2:22

    Content type: Commentary

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  15. All human immunodeficiency virus (HIV-1) uses a host tRNALys,3 as the primer for reverse transcription. The tRNALys,3 is bound to a region on the HIV-1 genome, the primer-binding site (PBS), that is complementary...

    Authors: Kenda L Moore-Rigdon, Barry R Kosloff, Richard L Kirkman and Casey D Morrow

    Citation: Retrovirology 2005 2:21

    Content type: Research

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  16. Despite the success of HAART, patients often stop treatment due to the inception of side effects. Furthermore, viral resistance often develops, making one or more of the drugs ineffective. Identification of no...

    Authors: Winnie S Liang, Anil Maddukuri, Tanya M Teslovich, Cynthia de la Fuente, Emmanuel Agbottah, Shabnam Dadgar, Kylene Kehn, Sampsa Hautaniemi, Anne Pumfery, Dietrich A Stephan and Fatah Kashanchi

    Citation: Retrovirology 2005 2:20

    Content type: Research

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  17. Most Internet online resources for investigating HIV biology contain either bioinformatics tools, protein information or sequence data. The objective of this study was to develop a comprehensive online proteom...

    Authors: Ryan S Doherty, Tulio De Oliveira, Chris Seebregts, Sivapragashini Danaviah, Michelle Gordon and Sharon Cassol

    Citation: Retrovirology 2005 2:18

    Content type: Review

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  18. Adult T-cell leukemia (ATL) was first reported as a distinct clinical entity in 1977 in Japan. The predominant physical findings are skin lesions, lymphadenopathy and hepatosplenomegaly. The ATL cells are of m...

    Authors: Kiyoshi Takatsuki

    Citation: Retrovirology 2005 2:16

    Content type: Review

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  19. On February 11, 2005, the New York City Department of Health and Mental Hygiene announced that a city resident had recently been infected with a multi-drug resistant form of HIV and rapidly progressed to AIDS....

    Authors: Stephen M Smith

    Citation: Retrovirology 2005 2:14

    Content type: Commentary

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  20. New York City health officials announced on February 11, 2005 that a patient rapidly developed full-blown AIDS shortly after being diagnosed with a rare, drug-resistant strain of HIV-1. The New York City Depar...

    Authors: Ben Berkhout, Anthony de Ronde and Lia van der Hoek

    Citation: Retrovirology 2005 2:13

    Content type: Commentary

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  21. The human immunodeficiency virus type 1 (HIV-1) is the primary cause of the acquired immunodeficiency syndrome (AIDS), which is a slow, progressive and degenerative disease of the human immune system. The path...

    Authors: Morten Hjuler Nielsen, Finn Skou Pedersen and Jørgen Kjems

    Citation: Retrovirology 2005 2:10

    Content type: Review

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  22. The nuclear transcription factor NF-κB binds to the HIV-1 long terminal repeat (LTR) and is a key regulator of HIV-1 gene expression in cells latently infected with this virus. In this report, we have analyzed...

    Authors: Qinmiao Sun, Hittu Matta and Preet M Chaudhary

    Citation: Retrovirology 2005 2:9

    Content type: Research

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  23. HIV-1 Tat activates transcription of HIV-1 viral genes by inducing phosphorylation of the C-terminal domain (CTD) of RNA polymerase II (RNAPII). Tat can also disturb cellular metabolism by inhibiting prolifera...

    Authors: Nicolas Epie, Tatyana Ammosova, Tamar Sapir, Yaroslav Voloshin, William S Lane, Willie Turner, Orly Reiner and Sergei Nekhai

    Citation: Retrovirology 2005 2:6

    Content type: Research

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  24. HIV infection and progression to AIDS is characterized by the depletion of T cells, which could be due, in part, to apoptosis mediated by the extra-cellular HIV-encoded Tat protein as a consequence of Tat bind...

    Authors: Jean de Mareuil, Manon Carre, Pascale Barbier, Grant R Campbell, Sophie Lancelot, Sandrine Opi, Didier Esquieu, Jennifer D Watkins, Charles Prevot, Diane Braguer, Vincent Peyrot and Erwann P Loret

    Citation: Retrovirology 2005 2:5

    Content type: Research

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  25. Human T-lymphotropic virus type 1 (HTLV-1) proviral load is related to the development of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and has also been shown to be elevated in the perip...

    Authors: Maria Yakova, Agnès Lézin, Fabienne Dantin, Gisèle Lagathu, Stéphane Olindo, Georges Jean-Baptiste, Serge Arfi and Raymond Césaire

    Citation: Retrovirology 2005 2:4

    Content type: Research

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  26. Retroviruses have a diploid genome and recombine at high frequency. Recombinant proviruses can be generated when two genetically different RNA genomes are packaged into the same retroviral particle. It was sho...

    Authors: Sergey A Kharytonchyk, Alla I Kireyeva, Anna B Osipovich and Igor K Fomin

    Citation: Retrovirology 2005 2:3

    Content type: Research

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  27. The antibacterial activity of host defense peptides (HDP) is largely mediated by permeabilization of bacterial membranes. The lipid membrane of enveloped viruses might also be a target of antimicrobial peptide...

    Authors: Lars Steinstraesser, Bettina Tippler, Janine Mertens, Evert Lamme, Heinz-Herbert Homann, Marcus Lehnhardt, Oliver Wildner, Hans-Ulrich Steinau and Klaus Überla

    Citation: Retrovirology 2005 2:2

    Content type: Research

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  28. Several cellular positive and negative elongation factors are involved in regulating RNA polymerase II processivity during transcription elongation in human cells. In recruiting several of these regulatory fac...

    Authors: Yueh-Hsin Ping, Chia-ying Chu, Hong Cao, Jean-Marc Jacque, Mario Stevenson and Tariq M Rana

    Citation: Retrovirology 2004 1:46

    Content type: Research

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  29. The identification of the molecular mechanisms of human immunodeficiency virus type 1, HIV-1, transcriptional regulation is required to develop novel inhibitors of viral replication. NF-κB transacting factors ...

    Authors: Camillo Palmieri, Francesca Trimboli, Antimina Puca, Giuseppe Fiume, Giuseppe Scala and Ileana Quinto

    Citation: Retrovirology 2004 1:45

    Content type: Research

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  30. MicroRNAs (miRNAs) are 21~25-nucleotides (nt) long and interact with mRNAs to trigger either translational repression or RNA cleavage through RNA interference (RNAi), depending on the degree of complementarity...

    Authors: Shinya Omoto, Masafumi Ito, Yutaka Tsutsumi, Yuko Ichikawa, Harumi Okuyama, Ebiamadon Andi Brisibe, Nitin K Saksena and Yoichi R Fujii

    Citation: Retrovirology 2004 1:44

    Content type: Research

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  31. MicroRNAs (miRNAs) are small RNAs of 21–25 nucleotides that specifically regulate cellular gene expression at the post-transcriptional level. miRNAs are derived from the maturation by cellular RNases III of im...

    Authors: Yamina Bennasser, Shu-Yun Le, Man Lung Yeung and Kuan-Teh Jeang

    Citation: Retrovirology 2004 1:43

    Content type: Short report

    Published on:

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