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  1. Content type: Editorial

    Retrovirology has been publishing as an Open Access online journal for approximately six months. In this editorial, I review the reasons for and the advantages of Open Access publishing, update our progress to...

    Authors: Kuan-Teh Jeang

    Citation: Retrovirology 2004 1:24

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  2. Content type: Research

    The HIV-1 genome encodes a well-conserved accessory gene product, Vpr, that serves multiple functions in the retroviral life cycle, including the enhancement of viral replication in nondividing macrophages, th...

    Authors: Xiao-Jian Yao, Nicole Rougeau, Ghislaine Duisit, Julie Lemay and Éric A Cohen

    Citation: Retrovirology 2004 1:21

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  3. Content type: Research

    Human T-cell leukemia virus type I (HTLV-I) Tax protein is a transcriptional regulator of viral and cellular genes. In this study we have examined in detail the determinants for Tax-mediated transcriptional ac...

    Authors: Yick-Pang Ching, Abel CS Chun, King-Tung Chin, Zhi-Qing Zhang, Kuan-Teh Jeang and Dong-Yan Jin

    Citation: Retrovirology 2004 1:18

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  4. Content type: Commentary

    The viral transactivator of HTLV-I, Tax, has long been shown to target the earliest steps of transcription by forming quaternary complexes with sequence specific transcription factors and histone-modifying enz...

    Authors: Cynthia de la Fuente and Fatah Kashanchi

    Citation: Retrovirology 2004 1:19

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  5. Content type: Research

    The viral and host factors involved in transmission of HIV through breastfeeding are largely unknown, and intervention strategies are urgently needed to protect at-risk populations. To evaluate the viral and i...

    Authors: Angela M Amedee, Jenna Rychert, Nedra Lacour, Lynn Fresh and Marion Ratterree

    Citation: Retrovirology 2004 1:17

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  6. Content type: Hypothesis

    The HIV-1 plague continues unabatedly across sub-Saharan Africa. In Botswana and Swaziland, nearly 40% of the entire adult population is already infected. No current program is capable of slowing the advancing...

    Authors: Stephen M Smith

    Citation: Retrovirology 2004 1:16

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  7. Content type: Research

    Despite the effectiveness of currently available antiretroviral therapies in the treatment of HIV-1 infection, a continuing need exists for novel compounds that can be used in combination with existing drugs t...

    Authors: Jing Zhou, Chin Ho Chen and Christopher Aiken

    Citation: Retrovirology 2004 1:15

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  8. Content type: Review

    Apoptosis, or programmed cell death, is a key event in biologic homeostasis but is also involved in the pathogenesis of many human diseases including human immunodeficiency virus (HIV) infection. Although mult...

    Authors: Barbara Ahr, Véronique Robert-Hebmann, Christian Devaux and Martine Biard-Piechaczyk

    Citation: Retrovirology 2004 1:12

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  9. Content type: Research

    Since the discovery of human immunodeficiency virus (HIV-1) twenty years ago, AIDS has become one of the most studied diseases. A number of viruses have subsequently been identified to contribute to the pathog...

    Authors: Elodie Ghedin, Anne Pumfery, Cynthia de la Fuente, Karen Yao, Naomi Miller, Vincent Lacoste, John Quackenbush, Steven Jacobson and Fatah Kashanchi

    Citation: Retrovirology 2004 1:10

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  10. Content type: Review

    During the last two decades, the profusion of HIV research due to the urge to identify new therapeutic targets has led to a wealth of information on the retroviral replication cycle. However, while the late st...

    Authors: Sébastien Nisole and Ali Saïb

    Citation: Retrovirology 2004 1:9

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  11. Content type: Commentary

    Recent data have established the HIV-1 and SIV escape CTL through epitope mutation. However, three novel studies prove that such escape comes at a "cost" to overall viral fitness. Understanding how HIV-1/SIV e...

    Authors: Stephen M Smith

    Citation: Retrovirology 2004 1:8

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  12. Content type: Research

    It is poorly understood why many transforming proteins reportedly enhance both cell growth (transformation) and cell death (apoptosis). At first glance, the ability to transform and the ability to engender apo...

    Authors: Takefumi Kasai and Kuan-Teh Jeang

    Citation: Retrovirology 2004 1:7

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  13. Content type: Research

    The human T-cell leukemia virus type 1 (HTLV-1) Tax protein indirectly influences transcriptional activation, signal transduction, cell cycle control, and apoptosis. The function of Tax primarily relies on pro...

    Authors: Kylene Kehn, Longwen Deng, Cynthia de la Fuente, Katharine Strouss, Kaili Wu, Anil Maddukuri, Shanese Baylor, Robyn Rufner, Anne Pumfery, Maria Elena Bottazzi and Fatah Kashanchi

    Citation: Retrovirology 2004 1:6

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  14. Content type: Research

    To generate a replication-competent retrovirus that could be conditionally inactivated, we flanked the viral genes of the Akv murine leukemia virus with LoxP sites. This provirus can delete its envelope gene b...

    Authors: Clifford L Wang, J Graeme Hodgson, Tiffany Malek, Finn Skou Pedersen and Matthias Wabl

    Citation: Retrovirology 2004 1:5

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  15. Content type: Research

    HTLV-I is associated with adult T-cell leukemia, and both HTLV-I and -II are associated with HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Several published reports suggest that HTLV-I may...

    Authors: Jennie R Orland, Baoguang Wang, David J Wright, Catharie C Nass, George Garratty, James W Smith, Bruce Newman, Donna M Smith and Edward L Murphy

    Citation: Retrovirology 2004 1:4

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  16. Content type: Research

    We previously described the construction of an HIV-1 envelope glycoprotein complex (Env) that is stabilized by an engineered intermolecular disulfide bond (SOS) between gp120 and gp41. The modified Env protein...

    Authors: Rogier W Sanders, Martijn M Dankers, Els Busser, Michael Caffrey, John P Moore and Ben Berkhout

    Citation: Retrovirology 2004 1:3

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  17. Content type: Research

    CCR5 and CXCR4 are the two main coreceptors essential for HIV entry. Therefore, these chemokine receptors have become important targets in the search for anti-HIV agents. Here, we describe the establishment of...

    Authors: Katrien Princen, Sigrid Hatse, Kurt Vermeire, Erik De Clercq and Dominique Schols

    Citation: Retrovirology 2004 1:2

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