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  1. The persistence of latent HIV-1 reservoirs is the principal barrier preventing the eradication of HIV-1 infection in patients by current antiretroviral therapy. It is thus crucial to understand the molecular m...

    Authors: Sandie Munier, Delphine Delcroix-Genête, Laëtitia Carthagéna, Audrey Gumez and Uriel Hazan
    Citation: Retrovirology 2005 2:73
  2. Every year the Cancer Research Institute from University of California at Irvine organizes the West Coast Retrovirus Meeting where participants have a chance to discuss the latest progress in understanding the...

    Authors: Sheila M Barry, Marta Melar, Philippe Gallay and Thomas J Hope
    Citation: Retrovirology 2005 2:72
  3. Human T-cell leukemia virus type 1 and type 2 are related human retroviruses. HTLV-1 is the etiological agent of the Adult T-cell Leukemia/Lymphoma and of the Tropical Spastic Paraparesis/HTLV-1 Associated Mye...

    Authors: Sébastien A Chevalier, Laurent Meertens, Sara Calattini, Antoine Gessain, Lars Kiemer and Renaud Mahieux
    Citation: Retrovirology 2005 2:70
  4. Human immunodeficiency virus type 1 (HIV-1) Tat transactivation is an essential step in the viral life cycle. Over the past several years, it has become widely accepted that Tat exerts its transcriptional effe...

    Authors: John Brady and Fatah Kashanchi
    Citation: Retrovirology 2005 2:69
  5. Given the high prevalence of mother to child infection, the development of a better understanding of African subtype C HIV-1 transmission and natural evolution is of significant importance. In this study, we g...

    Authors: Hong Zhang, Federico Hoffmann, Jun He, Xiang He, Chipepo Kankasa, Ruth Ruprecht, John T West, Guillermo Orti and Charles Wood
    Citation: Retrovirology 2005 2:67
  6. We have examined the kinetics of processing of the HIV-1 Gag-Pro-Pol precursor in an in vitro assay with mature protease added in trans. The processing sites were cleaved at different rates to produce distinct...

    Authors: Steve C Pettit, Jeffrey N Lindquist, Andrew H Kaplan and Ronald Swanstrom
    Citation: Retrovirology 2005 2:66
  7. Increasing evidence indicates that RNA interference (RNAi) may be used to provide antiviral immunity in mammalian cells. Human micro (mi)RNAs can inhibit the replication of a primate virus, whereas a virally-e...

    Authors: Anne Gatignol, Sébastien Lainé and Guerline Clerzius
    Citation: Retrovirology 2005 2:65
  8. Human T-cell leukemia virus type I (HTLV-I) causes adult T-cell leukemia (ATL) after a long latent period. Among accessory genes encoded by HTLV-I, the tax gene is thought to play a central role in oncogenesis. H...

    Authors: Yuko Taniguchi, Kisato Nosaka, Jun-ichirou Yasunaga, Michiyuki Maeda, Nancy Mueller, Akihiko Okayama and Masao Matsuoka
    Citation: Retrovirology 2005 2:64

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