Volume 9 Supplement 2

AIDS Vaccine 2012

Meeting abstracts

AIDS Vaccine 2012. Go to conference site.

Boston, MA, USA9-12 September 2012

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SIVconsv DNA prime - TLR7/IFNα adjuvanted long peptide boost induces potent CD4+ Ab responses and protects against high dose intrarectal SIV challenge

Authors: G Koopman, N Beenhakker, I Nieuwenhuis, G Doxiadis, P Mooij, JW Drijfhout, J Koestler, T Hanke, RE Bontrop, R Wagner, WM Bogers and CJ Melief

Citation: Retrovirology 2012 9(Suppl 2):P29

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Modelling the neuropathological consequences of HIV vaccines that confer partial protection

Authors: D Ferguson, S Clarke, C Ham, A Das, B Berkhout, A Meiser, S Patterson, N Berry and N Almond

Citation: Retrovirology 2012 9(Suppl 2):P30

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Optimizing delivery of HIV-1 conserved region-derived immunogen for induction of T and B cell responses in rhesus macaques

Authors: M Rosario, G Koopman, A Mbewe-Mvula, ML Knudsen, ED Quakkelaar, N Borthwick, R Wagner, DA Price, P Liljestrom, CJ Melief, JW Drijfhout, S Colloca, A Nicosia and T Hanke

Citation: Retrovirology 2012 9(Suppl 2):P31

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A single dose of SAAVI MVA-C reboosts rhesus macaques after more than 3 years post DNA-MVA prime-boost vaccination

Authors: GK Chege, W Burgers, T Muller, EG Shephard, C Williamson and A Williamson

Citation: Retrovirology 2012 9(Suppl 2):P32

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Maturation of protective immunity induced by SIVΔnef correlates with differential expression of transcription factors in SIV-specific CD8+ T cells

Authors: JM Billingsley, PA Rajakumar, NC Salisch, YV Kuzmichev, HS Hong, MA Connole, RK Reeves, H Kang, W Li and RP Johnson

Citation: Retrovirology 2012 9(Suppl 2):P33

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Mapping of SIVmac T-cell epitopes in cynomolgus macaques immunized with auxo-GTU-MultiSIV DNA by the intradermal route followed by electroporation

Authors: A Corneau, B Maciel Da Silva, S Even, J Morin, N Sylla, F Martinon, A Aarninck, A Blancher, I Stanescu, R Le Grand and N Dereuddre-Bosquet

Citation: Retrovirology 2012 9(Suppl 2):P34

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Development of a HIV-1 vaccine using an orally-administered, replication-competent adenovirus serotype 4 vector expressing Env clade C glycoprotein

Authors: J Alexander, M Gurwith, J Mendy, L Vang, D Manayani, J Avanzini, B Guenther, P Farness, BF Haynes, H Liao, DC Montefiori, CC LaBranche and T Mayall

Citation: Retrovirology 2012 9(Suppl 2):P35

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Differential induction of activation and apoptosis by TCR signaling in sooty mangabeys and rhesus macaques

Authors: S Yu, K Rogers, F Villinger and A Kaur

Citation: Retrovirology 2012 9(Suppl 2):P36

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Assessing the protective efficacy of antibodies to the HIV gp41 region by active vaccination

Authors: SK Sharma, J Pokorski, MG Finn, J Jacqueline, E Rakasz, D Burton and R Wyatt

Citation: Retrovirology 2012 9(Suppl 2):P37

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Expression and function of FcγRII on NK cells in rhesus macaques

Authors: X He, H Peng, Z Luo, D Liu, H Liang and Y Shao

Citation: Retrovirology 2012 9(Suppl 2):P38

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Protection against highly pathogenic SIV by BCG-SIV recombinant priming and attenuated replicating vaccinia-SIV recombinant boosting

Authors: X Zhang, H Sakawaki, T Miura, T Igarashi, S Horibata, K Yokomizo, K Matsuo, N Yamamoto, IB Fofana, W Johnson, T Ohashi and H Shida

Citation: Retrovirology 2012 9(Suppl 2):P39

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A prime-boost immunization with rBCG expressing HIV-1 Gag, RT and gp120 and SAAVI MVA-C elicits immune responses in blood and MALT of rhesus macaques

Authors: GK Chege, R Chapman, EG Shephard and A Williamson

Citation: Retrovirology 2012 9(Suppl 2):P40

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Passive immunization with polyclonal anti-SHIV IgG: partial protection or increased acquisition of heterologous tier 2 SHIV – depending on IgG dose

Authors: AM Sholukh, NB Siddappa, V Shanmuganathan, SK Lakhashe, RA Rasmussen, JD Watkins, HK Vyas, MM Mukhtar, G Hemashettar, S Thorat, JK Yoon, F Villinger, FJ Novembre, G Landucci, DN Forthal, S Ratcliffe…

Citation: Retrovirology 2012 9(Suppl 2):P41

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Vectored immunoprophylaxis protects humanized mice from mucosal HIV transmission

Authors: AB Balazs, J Chen, C Hong, S Ouyang, D An and D Baltimore

Citation: Retrovirology 2012 9(Suppl 2):P42

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Characterization in rabbits & nonhuman primates of the neutralizing antibody response elicited by DNA & protein vaccination with SIVmac251 & SIVsmE660

Authors: VP Menon, S Whitney, J Francis, L Ajayi, N Petrovsky, D Montefiori, R Pal and K Vaniambadi

Citation: Retrovirology 2012 9(Suppl 2):P43

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The breadth of maternal HIV-1 specific neutralizing antibodies is not associated with a lower risk of mother-to-infant transmission

Authors: A Chaillon, T Wack, M Braibant, L Mandelbrot, S Blanche, J Warszawski and F Barin

Citation: Retrovirology 2012 9(Suppl 2):P44

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Continuous evolution of HIV-1 more than ten years after infection in an elite neutralizer

Authors: A Chaillon, M Braibant, S Hué, S Bencharif, A Moreau, D Enard, A Samri, H Agut and F Barin

Citation: Retrovirology 2012 9(Suppl 2):P45

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V5 region in the HIV-1 envelope glycoprotein determines viral sensitivity to the broadly neutralizing monoclonal antibody VRC01

Authors: D Guo, X Shi, K Arledge, D Song, L Jiang, L Fu, S Zhang, X Wang and L Zhang

Citation: Retrovirology 2012 9(Suppl 2):P46

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Comprehensive mapping of SIVmac239 envelope antigenic determinants recognized by specific polyclonal antibodies in vaccinated and/or infected macaques

Authors: J Guo, T Zuo, L Zhang and Z Chen

Citation: Retrovirology 2012 9(Suppl 2):P47

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Recognition and penetration of the HIV-1 Env glycan shield by potent broadly neutralizing antibodies

Authors: J Julien, L Kong, R Pejchal, R Khayat, J Lee, RS Stanfield, LM Walker, KJ Doores, E Folkowska, P Poignard, R Depetris, RW Sanders, WC Koff, JP Moore, AB Ward, DR Burton…

Citation: Retrovirology 2012 9(Suppl 2):P48

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Neutralization and enhancement of trans infection by erythrocyte-bound HIV with antibodies and complement

Authors: Z Beck, GR Matyas, VR Polonis and CR Alving

Citation: Retrovirology 2012 9(Suppl 2):P49

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Design of epitope-specific probes for sera analysis and antibody isolation

Authors: I Georgiev, P Acharya, SD Schmidt, Y Li, D Wycuff, G Ofek, N Doria-Rose, TS Luongo, Y Yang, T Zhou, BR Donald, JR Mascola and PD Kwong

Citation: Retrovirology 2012 9(Suppl 2):P50

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Critical role for monocytes in mediating HIV-specific antibody-dependent cellular cytotoxicity

Authors: M Kramski, GF Lichtfuss, A Schorcht, AP Johnston, R De Rose, R Center, A Jawarowski and S Kent

Citation: Retrovirology 2012 9(Suppl 2):P51

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HIV-1 envelope glycoprotein characteristics that correlate with the development of cross-reactive neutralizing activity in HIV-1 infected individuals

Authors: TL van den Kerkhof, Z Euler, MJ van Gils, BD Boeser-Nunnink, NL Verwer, H Schuitemaker and RW Sanders

Citation: Retrovirology 2012 9(Suppl 2):P52

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Cross-group neutralization of HIV-1 and evidence for conservation of the PG9/PG16 epitopes within divergent groups of HIV-1

Authors: M Braibant, E Gong, J Plantier, F Simon and F Barin

Citation: Retrovirology 2012 9(Suppl 2):P53

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Residue 315 regulates V3 exposure and V3 antibody recognition on HIV subtype B and C viruses

Authors: S Manhas, B Clark, MK Gorny, S Zolla-Pazner and R Pantophlet

Citation: Retrovirology 2012 9(Suppl 2):P54

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Plasma antibodies that cross react to subtype-B and C third variable (V3) region develop in Indian HIV-1 infected iIndividuals with time

Authors: R Andrabi, A Gupta, M Bala and K Luthra

Citation: Retrovirology 2012 9(Suppl 2):P55

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Cross-reactive neutralizing activity in HIV-1 infected injecting drug users

Authors: Z Euler, MJ van Gils and H Schuitemaker

Citation: Retrovirology 2012 9(Suppl 2):P56

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Structural definition for a new modality of broad and potent antibody neutralization at the CD4-binding site on HIV-1 gp120

Authors: T Zhou, S Moquin, R Lynch, X Wu, J Zhu, Y Yang, B Zhang, JR Mascola and PD Kwong

Citation: Retrovirology 2012 9(Suppl 2):P57

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The impact of differences in viral entry and trafficking on the mechanism of HIV-1 neutralization

Authors: CD Macedo Cincotta, LM Wieczorek, B Barrows, B Brown, L Asher, N Michael, M Marovich and VR Polonis

Citation: Retrovirology 2012 9(Suppl 2):P58

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Rate and affinity binding constants determined by SPR spectroscopy reveal differential antigenicity of HIV gp120 and gp140

Authors: TL Gearhart, JD Steckbeck, JK Craigo and RC Montelaro

Citation: Retrovirology 2012 9(Suppl 2):P59

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Neutralizing anti-HIV antibodies develop in a humanized mouse model of HIV-1 infection

Authors: E Seung, A Dugast, T Dudek, H Mattoo, V Vrbanac, T Tivey, T Murooka, A Cariappa, AD Luster, S Pillai and AM Tager

Citation: Retrovirology 2012 9(Suppl 2):P60

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A comprehensive binding and neutralization analysis of plasma of HIV-1 subtype-C infected donors from India suggest MPER directed neutralization

Authors: R Andrabi, M Bala, R Kumar and K Luthra

Citation: Retrovirology 2012 9(Suppl 2):P61

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Highly efficient neutralization of human immunodeficiency viruses by plasma from antiretroviral drug treated patients is mediated by IgG fractions

Authors: R Andrabi, M Makhdoomi, R Kumar, M Bala, T Velpandian and K Luthra

Citation: Retrovirology 2012 9(Suppl 2):P62

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Modulation of antibody secreting cells and neutralizing Ab activity in HIV infected individuals undergoing structured treatment interruptions

Authors: A Llano, J Carrillo, B Mothe, S Marfil, E García, L Ruiz, E Yuste, V Sanchez, J Blanco and C Brander

Citation: Retrovirology 2012 9(Suppl 2):P63

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Construction and characterization of neutralizing antibody fragments for efficient access to V3 epitope

Authors: Y Maruta

Citation: Retrovirology 2012 9(Suppl 2):P64

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Affinity maturation pathway of an anti-MPER neutralizing mAb, CAP206-CH12

Authors: NL Tumba, ES Gray, BE Lambson, SS Abdool Karim, H Liao, BF Haynes, M Alam and L Morris

Citation: Retrovirology 2012 9(Suppl 2):P65

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Comparison of the neutralization sensitivity of South African and Indian HIV-1 subtype C viruses to South African plasma antibodies

Authors: T Hermanus, N Mkhize, P Moore, M Nonyane, J Battacharya, SA Karim and L Morris

Citation: Retrovirology 2012 9(Suppl 2):P66

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Biophysical dissection of the antigen-antibody interaction of the broadly reactive anti-V3 human mAb 447-52D

Authors: A Killikelly, H Zhang, B Spurrier, C Williams, MK Gorny, S Zolla-Pazner and X Kong

Citation: Retrovirology 2012 9(Suppl 2):P67

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Characteristics of HIV-1 gp120 molecules that bind ancestor, intermediate and mature forms of VRC01-like antibodies

Authors: M Joyce, B Zhang, T Zhou, S Moquin, X Wu, M Louder, Z Zhang, I Georgiev, J Zhu, L Shapiro, JR Mascola, GJ Nabel and PD Kwong

Citation: Retrovirology 2012 9(Suppl 2):P68

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Optimization and validation of the HIV-1 neutralizing antibody assay in A3R5 cells

Authors: M Sarzotti-Kelsoe, X Daniell, CA Todd, M Bilska, C LaBranche, LG Perez, C Ochsenbauer, J Kappes, W Rountree, DA Ozaki, JH Kim, R McLinden, T Denny and DC Montefiori

Citation: Retrovirology 2012 9(Suppl 2):P69

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Crystal structure analysis of anti-V2 mAb 2158 suggests a conformational epitope involving an N-linked glycan

Authors: B Spurrier, R Pan, J Sampson, C Williams, M Gorny, S Zolla-Pazner and X Kong

Citation: Retrovirology 2012 9(Suppl 2):P70

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Detection of antibodies to the α4β7 integrin binding site on HIV-1 gp120 V2 loop using a novel cell adhesion assay

Authors: M Rao, N Karasavvas, A Pinter, H Liao, M Bonsignori, B Mathieson, S Zolla-Pazner, BF Haynes, NL Michael, JH Kim, CR Alving and KK Peachman

Citation: Retrovirology 2012 9(Suppl 2):P71

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Superinfection by discordant subtypes of HIV-1 does not enhance the neutralizing antibody response against autologous virus

Authors: LM Mayr, RL Powell, JN Ngai, A Nádas and PN Nyambi

Citation: Retrovirology 2012 9(Suppl 2):P72

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Hyperglycosylated gp120 mutants elicit improved CD4-binding site directed antibodies in a heterologous prime:boost regimen

Authors: FK Ahmed, BE Clark and R Pantophlet

Citation: Retrovirology 2012 9(Suppl 2):P73

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Structural comparison of somatically related PG9 and PG16 in complex with their epitope reveals differences in glycan recognition

Authors: M Pancera, JS McLellan, S Shahzad-ul-Hussan, N Doria-Rose, B Zhang, Y Yang, DR Burton, WC Koff, CA Bewley and PD Kwong

Citation: Retrovirology 2012 9(Suppl 2):P74

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Neutralizing and non-neutralizing antibody responses in HIV-1 subtype C chronically infected patients with divergent rates of disease progression

Authors: D Archary, R Rong, ML Gordon, S Boliar, ES Gray, A Dugast, T Hermanus, PJ Goulder, HM Coovadia, L Morris, G Alter, CA Derdeyn and T Ndung'u

Citation: Retrovirology 2012 9(Suppl 2):P75

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Structural analyses of antigen binding similarities and differences between rabbit and human anti-gp120 V3 mAbs

Authors: R Pan, JM Sampson, Y Chen, M Vaine, S Wang, S Lu and X Kong

Citation: Retrovirology 2012 9(Suppl 2):P76

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Refined identification of neutralization-resistant CRF02_AG viruses and their sensitivity to anti-MPER neutralizing antibodies

Authors: RA Jacob, F Abrahams, M Tongo, M Schomaker, P Roux, E Mpoudi Ngole, WA Burgers and JR Dorfman

Citation: Retrovirology 2012 9(Suppl 2):P77

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Antibody-dependent cellular cytotoxicity-mediating antibodies from an HIV-1 vaccine efficacy trial preferentially use the VH1 gene family

Authors: M Bonsignori, J Pollara, MA Moody, TB Kepler, X Chen, TC Gurley, DM Kozink, DJ Marshall, JF Whitesides, J Kaewkungwal, S Nitayaphan, P Pitisuttithum, S Rerks-Ngarm, JH Kim, NL Michael, DC Montefiori…

Citation: Retrovirology 2012 9(Suppl 2):P78

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