Volume 9 Supplement 2

AIDS Vaccine 2012

Meeting abstracts

AIDS Vaccine 2012. Go to conference site.

Boston, MA, USA9-12 September 2012

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Significant protection from infection and AIDS progression after gastrointestinal and oral vaccinations, respectively, with a SIV DNA/rMVA vaccine

Authors: A Aldovini, M Manrique, A Cobo-Molinos, P Kozlowski and A Carvlle

Citation: Retrovirology 2012 9(Suppl 2):O1

Content type: Oral presentation Published on: 13 September 2012
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Antibodies to the envelope protein protect macaques from SIVmac251 acquisition in an immunization regimen that mimics the RV-144 Thai trial

Authors: G Franchini, P Pegu, S Gordon, B Keele, M Doster, Y Guan, G Ferrari, R Pal, MG Ferrari, S Whitney, L Hudacik, E Billings, M Rao, D Montefiori, D Venzon, C Fenizia…

Citation: Retrovirology 2012 9(Suppl 2):O2

Content type: Oral presentation Published on: 13 September 2012
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Immune control of an SIV challenge by a heterolgous and direct mucosal vaccination regimen in rhesus monkeys

Authors: C Sun, Z Chen, X Tang, Y Zhang, L Feng, Y Du, L Xiao, L Liu, W Zhu, L Chen and L Zhang

Citation: Retrovirology 2012 9(Suppl 2):O3

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A recombinant attenuated Mycobacterium tuberculosis-SIV combination vaccine is safe and immunogenic in immunocompromised, SIV-infected infant macaques

Authors: K Jensen, UD Ranganathan, P Kozlowski, K Van Rompay, D Canfield, R Ravindran, I Khan, P Luciw, G Fennelly, M Larsen and K Abel

Citation: Retrovirology 2012 9(Suppl 2):O4

Content type: Oral presentation Published on: 13 September 2012
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MAb PGT121 protects against mucosal SHIV challenge in macaques at concentrations corresponding to its highly potent in vitro neutralization capacity

Authors: B Moldt, EG Rakasz, N Schultz, P Chan-Hui, K Swiderek, DI Watkins, DR Burton and P Poignard

Citation: Retrovirology 2012 9(Suppl 2):O5

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Epitope specificity appears to be an important determinant of in vivo killing ability of simian immunodeficiency virus (SIV)-specific CD8+ T Cells

Authors: L Pozzi, A Carville, V Varner, J Sen, D Knipe and A Kaur

Citation: Retrovirology 2012 9(Suppl 2):O6

Content type: Oral presentation Published on: 13 September 2012
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Identification of a clade A HIV envelope immunogen from Protocol G that elicits neutralizing antibodies to tier 2 viruses

Authors: S Hoffenberg, S Kosakovsky Pond, A Carpov, D Wagner, A Wilson, R Powell, R Lindsay, H Arendt, J DeStefano, P Poignard, M Simek, S Fling, S Phogat, C Labranche, D Montefiori, D Burton…

Citation: Retrovirology 2012 9(Suppl 2):O7

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Prime-boost regimen potency and efficacy with alphavirus replicons (SIV antigen) in non-human primates challenged with low-dose intra-rectal SIVsmE660

Authors: K Banerjee, S Balsitis, T Jamil, C Jones, A Dey, J Flandez, L Brito, Y Cu, C Beard, S Santra, R Pal, N Miller, NM Valiante, P Mason, SW Barnett and GR Otten

Citation: Retrovirology 2012 9(Suppl 2):O8

Content type: Oral presentation Published on: 13 September 2012
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Minimally invasive and surface electroporation delivery of DNA vaccines for the induction of robust humoral immune responses against HIV antigens

Authors: NY Sardesai, AS Khan, J McCoy, F Lin, JM Mendoza, M Yang, J Yan, N Hutnick, K Muthumani, DB Weiner and KE Broderick

Citation: Retrovirology 2012 9(Suppl 2):O9

Content type: Oral presentation Published on: 13 September 2012
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Design of lipid nanoparticle delivery agents for multivalent display of recombinant Env trimers in HIV vaccination

Authors: S Pejawar-Gaddy, J Kovacs, D Barouch, B Chen and D Irvine

Citation: Retrovirology 2012 9(Suppl 2):O10

Content type: Oral presentation Published on: 13 September 2012
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Eliciting neutralizing antibodies with gp120 outer domain

Authors: Y Qin, DP Han, K Takamoto and MW Cho

Citation: Retrovirology 2012 9(Suppl 2):O11

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Oral immunization with a recombinant Lactococcus lactis expressing HIV-1 Gag on the tip of the pilus induces strong mucosal immune responses

Authors: V Chamcha, JR Scott and R Amara

Citation: Retrovirology 2012 9(Suppl 2):O12

Content type: Oral presentation Published on: 13 September 2012
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SIVΔnef vaccination mobilizes systemic and mucosal natural killer cells in Mamu A*01+ macaques

Authors: R Reeves, T Evans, J Gillis, M Connole, F Wong, Y Yu and R Johnson

Citation: Retrovirology 2012 9(Suppl 2):O13

Content type: Oral presentation Published on: 13 September 2012
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RV144-like trial in macaques using ALVAC-SIV & gp120 induces innate immunity and increases the frequency of NK22 & NKG2A+ cells in mucosal tissues

Authors: NP Liyanage, P Pegu, S Gordon, M Cameron, K Foulds, M Doster, M Vaccari, R Koup, M Roederer, R Sékaly and G Franchini

Citation: Retrovirology 2012 9(Suppl 2):O14

Content type: Oral presentation Published on: 13 September 2012
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Adenovirus vectors from various serotypes induce distinct cytokine profiles

Authors: JE Teigler, M Iampietro and DH Barouch

Citation: Retrovirology 2012 9(Suppl 2):O15

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Infiltration of dendritic cells and antigen uptake in the muscle after injection of HIV-1 Env gp120 in adjuvant

Authors: F Liang, KJ Sandgren, H Fausther-Bovendo, D O'hagan, A Seubert, E De Gregorio, S Rao, N Sullivan, RA Seder, RA Koup and K Loré

Citation: Retrovirology 2012 9(Suppl 2):O16

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Early pro-inflammatory host response to recombinant HSV-SIV vaccination in sooty mangabeys

Authors: N Rout, S Yu, V Varner, C Kasala-Hallinan, K Rogers, J Sen, D Knipe, F Villinger and A Kaur

Citation: Retrovirology 2012 9(Suppl 2):O17

Content type: Oral presentation Published on: 13 September 2012
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Vaccination with MVA/HIV induces differential recruitment of monocyte subsets into the circulation and monocyte-specific transcriptional programs

Authors: E Andersen-Nissen, DE Zak, TR Hensley, DJ Adams, X Hu, A Sato, M Elizaga, PA Goepfert, HL Robinson, A Aderem and MJ McElrath

Citation: Retrovirology 2012 9(Suppl 2):O18

Content type: Oral presentation Published on: 13 September 2012
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Immune complexes can dampen inflammatory signaling at the mucosal surface during protective SIV vaccination

Authors: AJ Smith, SW Wietgrefe, CS Reilly, PJ Southern, L Duan, KE Perkey, L Shang, R Johnson and AT Haase

Citation: Retrovirology 2012 9(Suppl 2):O19

Content type: Oral presentation Published on: 13 September 2012
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Vaccine-elicited systemic and mucosal humoral responses of lactating rhesus monkeys vaccinated with the transmitted/founder HIV Envelope 1086C

Authors: G Fouda, J Amos, AB Wilks, A Chand, D Montefiori, B Haynes, N Letvin, D Pickup, H Liao and SR Permar

Citation: Retrovirology 2012 9(Suppl 2):O20

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Expanded memory CD4+ T Cells in the fetal and the infant Gut; a mucosal route for mother-to-child transmission of HIV-1

Authors: MJ Bunders, C van der Loos, PL Klarenbeek, J van Hamme, J Wilde, N de Vries, RA van Lier, N Kootstra, ST Pals and TW Kuijpers

Citation: Retrovirology 2012 9(Suppl 2):O21

Content type: Oral presentation Published on: 13 September 2012
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Cell free HIV-1 virus can infect inner and outer foreskin polarized explants

Authors: MP Lemos, ML Perez, J Sanchez, J Lama, S Montano and J McElrath

Citation: Retrovirology 2012 9(Suppl 2):O22

Content type: Oral presentation Published on: 13 September 2012
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Inflammation in the male genital tract: implications for HIV acquisition and transmission

Authors: AJ Olivier, L Roberts, D Coetzee, A Williamson, JS Passmore and WA Burgers

Citation: Retrovirology 2012 9(Suppl 2):O23

Content type: Oral presentation Published on: 13 September 2012
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New tools to measure community and stakeholder engagement and its impact on outcomes of clinical research

Authors: P Bahati, S Hannah, S Seidel, S Aggett, R Siskind, R Campbell, S Williams, A Downie and S Rosas

Citation: Retrovirology 2012 9(Suppl 2):O24

Content type: Oral presentation Published on: 13 September 2012
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An assessment of Good Participatory Practice Guidelines at HIV prevention research clinical centers in Eastern and Southern Africa

Authors: BP Ngongo, S Hannah, J Mbogua, M Seyoum, M Warren, E Baas and F Priddy

Citation: Retrovirology 2012 9(Suppl 2):O25

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Social and ethical considerations in engaging American Indian and Alaska Native communities in HIV clinical research

Authors: J Velcoff, DL Humes, R Foley and M Ignacio

Citation: Retrovirology 2012 9(Suppl 2):O26

Content type: Oral presentation Published on: 13 September 2012
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Knowledge/attitude/practices of HPV & cervical cancer, willingness to participate in vaccine trial in preparation for HIV & HPV vaccine trials in Mali

Authors: D Poole, K Tracy, L Levitz, S Yekta, E Kossow, T Huang, M Rochas, K Sangare, K Tounkara, B Aboubacar, O Koita, F Siby Diallo, S Sow, I Téguété, A Dolo, F Bougoudogo…

Citation: Retrovirology 2012 9(Suppl 2):O27

Content type: Oral presentation Published on: 13 September 2012
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Referral and access to care of HIV prevalent cases; experience from the early capture HIV cohort study in Kampala

Authors: LN Mutengu, H Kibuuka, M Millard, A Sekiziyivu, S Wakabi, J Nanyondo, G Kawooya, M Robb and N Michael

Citation: Retrovirology 2012 9(Suppl 2):O28

Content type: Oral presentation Published on: 13 September 2012
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A short segment in the HIV-1 gp120 V1/V2 region is a major determinant of neutralization resistance to PG9-like antibodies

Authors: NA Doria-Rose, I Georgiev, RP Staupe, S O'Dell, G Chuang, J Gorman, JS McLellan, M Pancera, M Bonsignori, BF Haynes, DR Burton, WC Koff, PD Kwong and JR Mascola

Citation: Retrovirology 2012 9(Suppl 2):O29

Content type: Oral presentation Published on: 13 September 2012
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Characterization of V1V2-specific antibodies present in broadly neutralizing plasma isolated from HIV-1 infected individuals

Authors: C Krachmarov, K Revesz, R Prattipati, C Reichman, Z Lai, W Honnen, B Li, C Derdeyn and A Pinter

Citation: Retrovirology 2012 9(Suppl 2):O30

Content type: Oral presentation Published on: 13 September 2012
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Design of an HIV Env antigen that binds with high affinity to antibodies against linear, conformational and broadly neutralizing epitopes within V1/V2

Authors: L Liao, M Bonsignori, K Hwang, AM Moody, R Park, S Crawford, H Chen, TL Jeffries, M Cooper, X Lu, R De, N Karasavvas, S Rerks-Ngarm, S Nitayaphan, J Kaewkungwal, S Tovanabutra…

Citation: Retrovirology 2012 9(Suppl 2):O31

Content type: Oral presentation Published on: 13 September 2012
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Evidence for Env-V2 sieve effect in breakthrough SIV _MAC251 infections in rhesus monkeys vaccinated with Ad26/MVA and MVA/Ad26 constructs

Authors: S Sina, S Tovanabutra, E Sanders-Buell, A Bates, M Bose, S Howell, G Ibitamuno, M Lazzaro, A O'Sullivan, J Lee, T Cervenka, J Kuroiwa, K Baldwin, DH Barouch, M Robb, R O'Connell…

Citation: Retrovirology 2012 9(Suppl 2):O32

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Structural basis for germline gene usage of a potent class of antibodies targeting the CD4 binding site of HIV-1 gp120

Authors: AP West Jr., R Diskin, MC Nussenzweig and PJ Bjorkman

Citation: Retrovirology 2012 9(Suppl 2):O33

Content type: Oral presentation Published on: 13 September 2012
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Structure-guided modification and optimization of antibody VRC07

Authors: Y Kwon, I Georgiev, S O'Dell, W Shi, G Chuang, Y Yang, B Zhang, J Zhu, GJ Nabel, JR Mascola and PD Kwong

Citation: Retrovirology 2012 9(Suppl 2):O34

Content type: Oral presentation Published on: 13 September 2012
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Isolation of a clonal lineage of IgA broadly neutralizing antibodies from a chronically infected Tanzanian subject

Authors: M Moody, MS Drinker, TC Gurley, JD Amos, JA Eudailey, LC Armand, R Parks, ES Gray, L Morris, A Finzi, X Yang, J Sodroski, H Liao, GD Tomaras, DC Montefiori and BF Haynes

Citation: Retrovirology 2012 9(Suppl 2):O35

Content type: Oral presentation Published on: 13 September 2012
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Deep sequencing with longitudinal sampling of a VRC01-like-antibody response in a chronically infected individual

Authors: Z Zhang, X Wu, N Longo, B Zhang, J Zhu, C NISC, JC Mullikin, L Wu, GJ Nabel, M Connors, PD Kwong, JR Mascola and L Shapiro

Citation: Retrovirology 2012 9(Suppl 2):O36

Content type: Oral presentation Published on: 13 September 2012
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Antibody effector function is regulated by a combination of adaptive and innate signals

Authors: A Mahan, K Dionne, J Eusebio and G Alter

Citation: Retrovirology 2012 9(Suppl 2):O37

Content type: Oral presentation Published on: 13 September 2012
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Non-neutralizing IgG anti-PID antibodies decreased viral load following high dose vaginal challenge of non-human primates

Authors: C Moog, N Dereuddre-Bosquet, M Biedma, S Schmidt, T Decoville, I Mangeot, S Zolla-Pazner, B Vcelar, D Katinger, V Holl and R Le Grand

Citation: Retrovirology 2012 9(Suppl 2):O38

Content type: Oral presentation Published on: 13 September 2012
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Vaccine-induced ADCC-mediating antibodies target unique and overlapping envelope epitopes

Authors: J Pollara, M Bonsignori, M Moody, M Alam, H Liao, K Hwang, J Pickeral, J Kappes, C Ochsenbauer, K Soderberg, TC Gurley, DM Kozink, DJ Marshall, JF Whitesides, D Montefiori, JE Robinson…

Citation: Retrovirology 2012 9(Suppl 2):O39

Content type: Oral presentation Published on: 13 September 2012
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454 pyrosequencing and bioinformatics analysis of the lineage of the broad and potent gp41-directed antibody 10e8

Authors: G Ofek, J Zhu, Y Yang, B Zhang, K Mckee, M Louder, J Huang, L Laub, M Connors, J Mascola and PD Kwong

Citation: Retrovirology 2012 9(Suppl 2):O40

Content type: Oral presentation Published on: 13 September 2012
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Engineered mice and B cell lines expressing broadly neutralizing antibodies and their unmutated precursors: tools for HIV vaccinology

Authors: D Nemazee, C Doyle-Cooper, T Ota, AB Cooper, M Huber, E Falkowska, K Doores, L Hangartner, K Le, D Sok, J Jardine, J Lifson, X Wu, JR Mascola, P Poignard, JM Binley…

Citation: Retrovirology 2012 9(Suppl 2):O41

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Cellular immune responses and changes in VL after a Dendritic Cells (DC)-based therapeutic vaccine in cART treated chronic HIV-infected patients with CD4 T cells above 450/mm

Authors: F García, AC Guardo, M Maleno, L Papagno, M Bargalló, N Climent, B Autran, J Gatell, T Gallart and M Plana

Citation: Retrovirology 2012 9(Suppl 2):O42

Content type: Oral presentation Published on: 13 September 2012
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Alterations in function and distribution of regulatory T Cells (Tregs) may blunt vaccine induced immune responses in HIV infection

Authors: J van Lunzen, I Toth, P Hartjen and J Schulze zur Wiesch

Citation: Retrovirology 2012 9(Suppl 2):O43

Content type: Oral presentation Published on: 13 September 2012
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Identification of CD8+ T cell host factors involved in HIV control

Authors: G Gaiha, K McKim, M Woods, M Lichterfeld, A Brass and B Wallker

Citation: Retrovirology 2012 9(Suppl 2):O44

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PD-1, IL-10, IFN-γ and IL-12 form a network to regulate HIV-1-specific CD4 T Cell and antigen-presenting cell function

Authors: F Porichis, L Barblu, DS Kwon, M Hart, J Zupkosky, GJ Freeman, DG Kavanagh and DE Kaufmann

Citation: Retrovirology 2012 9(Suppl 2):O45

Content type: Oral presentation Published on: 13 September 2012
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Distinct gene expression profiles associated with the susceptibility of pathogen-specific CD4+ T cells to HIV-1 infection

Authors: H Hu, M Nau, P Ehrenberg, A Chenine, Z Daye, Z Wei, N Michael, M Vahey, J Kim, M Marovich and S Ratto-Kim

Citation: Retrovirology 2012 9(Suppl 2):O46

Content type: Oral presentation Published on: 13 September 2012
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HIV control through a single nucleotide on the HLA-I locus

Authors: H Kløverpris, M Harndahl, J Carlson, A Leslie, M van der Stok, G Huang, F Chen, L Riddell, D Steyn, D Goedhals, C van Vuuren, J Frater, B Walker, T Ndung'u', S Buus and P Goulder

Citation: Retrovirology 2012 9(Suppl 2):O47

Content type: Oral presentation Published on: 13 September 2012
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Accelerated heterologous prime-boost adenovirus vector-based SIV vaccine in neonatal rhesus monkeys

Authors: J Liu, H Li, M Iampietro and DH Barouch

Citation: Retrovirology 2012 9(Suppl 2):O48

Content type: Oral presentation Published on: 13 September 2012
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Intra-dermal immunisation with SIV gag-based vaccines alone inhibits acquisition of SIVmac251

Authors: N Almond, R Stebbings, M Page, B Li, N Berry, C Ham, D Ferguson, N Rose, E Mee, C Stahl-Hennig, G Dickson, T Athanasapoulos, A Benlahrech, S Herath, A Meiser and S Patterson

Citation: Retrovirology 2012 9(Suppl 2):O49

Content type: Oral presentation Published on: 13 September 2012
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Safety and immunogenicity of a randomized phase I prime-boost trial with ALVAC-HIV (vCP205) and gp160 MN/LAI-2 adjuvanted in alum or polyphosphazene

Authors: RJ O'Connell, VR Polonis, S Ratto-Kim, J Cox, LL Jagodzinski, J Malia, NL Michael, J Excler, ML Robb and JH Kim

Citation: Retrovirology 2012 9(Suppl 2):O50

Content type: Oral presentation Published on: 13 September 2012
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