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Volume 9 Supplement 2

AIDS Vaccine 2012

  • Poster presentation
  • Open Access

Human leukocyte antigen class I supertypes and viral control in HIV-1 infected former plasma donors from China

  • 1,
  • 1,
  • 1,
  • 1,
  • 1 and
  • 1
Retrovirology20129 (Suppl 2) :P167

https://doi.org/10.1186/1742-4690-9-S2-P167

  • Published:

Keywords

  • Viral Load
  • Human Leukocyte Antigen
  • Human Leukocyte Antigen Class
  • Plasma Viral Load
  • Human Leukocyte Antigen Allele

Background

The role of human leukocyte antigen (HLA) class I supertypes in controlling human immunodeficiency virus type 1 (HIV-1) infection in Chinese has not been established. The aim of this study is to examine the frequency of HLA-A and HLA-B alleles and supertypes of 222 HIV-1 infected former plasma donors in central China and to investigate their impact on HIV-1 viral control.

Methods

HLA-A and HLA-B alleles were genotyped with PCR-SSP and sequence-based typing assay to four-digit resolution. The HLA alleles were classified functionally to 4 HLA-A supertypes and 6 HLA-B supertypes according to their shared peptide binding properties. Plasma viral load was determined using the Roche Amplicor ultrasensitive assay which has a lower detection limit of 50 copies HIV-1 RNA per ml.

Results

HLA-A03 supertypes(A03s) and HLA-B62 supertypes(B62s) were associated with lower viral load (P=0.0206, P=0.0483), whereas HLA- A24 supertypes(A24s) appeared to have an association with higher viral load (P=0.0483). There was a highly significant correlation between the genotypic supertypes(GS) and viral load (Kendall's tau b = 0.180, P=0.000). The median viral load was lower among A*3001(P=0.0139), A*1101(P=0.0096), B*5101(P=0.0025), B*3501(P=0.0091) or B*4601(P=0.001) carriers and higher in A*2301(P=0.0106) carriers.

Conclusion

HLA-A03s and -B62s may be associated with favorable HIV-1 viral control, A24s associated with unfavorable viral control; HLA-B*4601 within B62s and HLA-A*2301 within A24s might contribute to the outcomes of HIV-1 viral control.

Authors’ Affiliations

(1)
National Center for AIDS/STD Control and Prevention, Beijing, China

Copyright

© Hao et al; licensee BioMed Central Ltd. 2012

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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