Figure 6
From: Host restriction factors in retroviral infection: promises in virus-host interaction
Schematic illustration of Vpx protein from SIVmac and human SAMHD1 protein. SAMHD1 splicing variants are shown on the top. Numbers indicate amino acid positions. The three α-helices of Vpx and the SAM, HD, and the C-terminal variable region of SAMHD1 are indicated. Other critical residues and motifs include nuclear localization signal (NLS), a critical residue that determines Vpx interaction with DCAF1 (Q76), four critical residues in SAMHD1 NLS (11KPPR14), and four residues in the HD domain (H167, H206, D207, D311) are all indicated.