Figure 4
From: Host restriction factors in retroviral infection: promises in virus-host interaction
Schematic illustration of human TRIM5α protein. Numbers indicate amino acid positions. The RING finger (R), B-box (B), coiled-coil motif (CC), two linkers (L1, L2), and SPRY domain are indicated. Four variable regions in SPRY, the critical residue (R121) in the B domain that determines oligomerization, and the critical residue (R332) in V1 region that determines species-specific Gag binding are also indicated.