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CD64 as a biomarker and therapeutic target in HAM/TSP and HTLV-1-associated Infective Dermatitis

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Previous studies have linked CD8+ T cell subset IFN-gamma production to HAM/TSP disease evolution [1, 2], as well as its dependence on infected monocytes (Enose-Akahata et al. 2008). In addition, infective dermatitis (ID) can trigger HAM/TSP in children and adolescents [3]. Therefore, we quantified ex vivo expression of IFN-gamma/STAT1-regulated genes CD64 and CD95 in monocytes and neutrophils by flow cytometry in 44 subjects from Brazil and Peru, ranging from normal donors (ND), asymptomatics (AS), infective dermatitis (ID) and HAM/TSP to HAM/TSP+ID co-morbidity. Ex vivo CD64 expression in neutrophils was significantly associated with disease progression, with ND.

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    Yamano Y, Araya N, Sato T, Utsunomiya A, Azakami K, Hasegawa D, Izumi T, Fujita H, Aratani S, Yagishita N, Fujii R, Nishioka K, Jacobson S, Nakajima T: Abnormally High Levels of Virus-Infected IFN-γ+CCR4+CD4+CD25+ T Cells in a Retrovirus-Associated Neuroinflammatory Disorder. PLoS One. 2009, 4 (8): e6517-10.1371/journal.pone.0006517.

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Correspondence to Ricardo Khouri.

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This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Keywords

  • Infectious Disease
  • Flow Cytometry
  • Cancer Research
  • Therapeutic Target
  • Dermatitis