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  • Meeting abstract
  • Open Access

CD64 as a biomarker and therapeutic target in HAM/TSP and HTLV-1-associated Infective Dermatitis

  • 1Email author,
  • 2,
  • 2,
  • 2,
  • 3,
  • 2,
  • 4,
  • 5,
  • 5,
  • 5,
  • 1,
  • 2 and
  • 1, 2
Retrovirology20118 (Suppl 1) :A95

https://doi.org/10.1186/1742-4690-8-S1-A95

  • Published:

Keywords

  • Infectious Disease
  • Flow Cytometry
  • Cancer Research
  • Therapeutic Target
  • Dermatitis

Previous studies have linked CD8+ T cell subset IFN-gamma production to HAM/TSP disease evolution [1, 2], as well as its dependence on infected monocytes (Enose-Akahata et al. 2008). In addition, infective dermatitis (ID) can trigger HAM/TSP in children and adolescents [3]. Therefore, we quantified ex vivo expression of IFN-gamma/STAT1-regulated genes CD64 and CD95 in monocytes and neutrophils by flow cytometry in 44 subjects from Brazil and Peru, ranging from normal donors (ND), asymptomatics (AS), infective dermatitis (ID) and HAM/TSP to HAM/TSP+ID co-morbidity. Ex vivo CD64 expression in neutrophils was significantly associated with disease progression, with ND.

Authors’ Affiliations

(1)
Rega Institute, K.U. Leuven, Leuven, Belgium
(2)
CPqGM-FIOCRUZ, Salvador-Bahia, Brazil
(3)
Fraunhofer Institute, Aachen, Germany
(4)
HUPES-UFBA, Salvador-Bahia, Brazil
(5)
Tropical Medicine Research Center, UCH, Lima, Peru

References

  1. Kubota R, Kawanishi T, Matsubara H, Manns A, Jacobson S: HTLV-I specific IFN-γ + CD8 + lymphocytes correlate with the proviral load in peripheral blood of infected individuals. J. Neuroimmunol. 2000, 102: 208-215. 10.1016/S0165-5728(99)00175-7.View ArticlePubMedGoogle Scholar
  2. Yamano Y, Araya N, Sato T, Utsunomiya A, Azakami K, Hasegawa D, Izumi T, Fujita H, Aratani S, Yagishita N, Fujii R, Nishioka K, Jacobson S, Nakajima T: Abnormally High Levels of Virus-Infected IFN-γ+CCR4+CD4+CD25+ T Cells in a Retrovirus-Associated Neuroinflammatory Disorder. PLoS One. 2009, 4 (8): e6517-10.1371/journal.pone.0006517.PubMed CentralView ArticlePubMedGoogle Scholar
  3. Primo J, Brites C, de Oliveira M, vio Moreno-Carvalho O, Machado M, Bittencourt A: Infective Dermatitis and Human T Cell Lymphotropic Virus Type 1–Associated Myelopathy/Tropical Spastic Paraparesis in Childhood and Adolescence. Clin Infect Dis. 2005, 41 (4): 535-541. 10.1086/432058.View ArticlePubMedGoogle Scholar

Copyright

© Khouri et al; licensee BioMed Central Ltd. 2011

This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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