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Volume 8 Supplement 1

15th International Conference on Human Retroviruses: HTLV and Related Viruses

CD64 as a biomarker and therapeutic target in HAM/TSP and HTLV-1-associated Infective Dermatitis

Retrovirology volume 8, Article number: A95 (2011) Cite this article

Previous studies have linked CD8+ T cell subset IFN-gamma production to HAM/TSP disease evolution [1, 2], as well as its dependence on infected monocytes (Enose-Akahata et al. 2008). In addition, infective dermatitis (ID) can trigger HAM/TSP in children and adolescents [3]. Therefore, we quantified ex vivo expression of IFN-gamma/STAT1-regulated genes CD64 and CD95 in monocytes and neutrophils by flow cytometry in 44 subjects from Brazil and Peru, ranging from normal donors (ND), asymptomatics (AS), infective dermatitis (ID) and HAM/TSP to HAM/TSP+ID co-morbidity. Ex vivo CD64 expression in neutrophils was significantly associated with disease progression, with ND.

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Authors and Affiliations

  1. Rega Institute, K.U. Leuven, Leuven, Belgium

    Ricardo Khouri, Anne-Mieke Vandamme & Johan Van Weyenbergh

  2. CPqGM-FIOCRUZ, Salvador-Bahia, Brazil

    George Soares, Gilvaneia Silva-Santos, Giselia Santana, Lourdes Farre, Bernardo Galvao-Castro & Johan Van Weyenbergh

  3. Fraunhofer Institute, Aachen, Germany

    Theo Thepen

  4. HUPES-UFBA, Salvador-Bahia, Brazil

    Achilea Bittencourt

  5. Tropical Medicine Research Center, UCH, Lima, Peru

    Giovanni Lopez, Michael Talledo & Eduardo Gotuzzo

Authors
  1. Ricardo Khouri
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  2. George Soares
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  3. Gilvaneia Silva-Santos
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  4. Giselia Santana
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  5. Theo Thepen
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  6. Lourdes Farre
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  7. Achilea Bittencourt
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  8. Giovanni Lopez
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  9. Michael Talledo
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  10. Eduardo Gotuzzo
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  11. Anne-Mieke Vandamme
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  12. Bernardo Galvao-Castro
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  13. Johan Van Weyenbergh
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Corresponding author

Correspondence to Ricardo Khouri.

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This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Khouri, R., Soares, G., Silva-Santos, G. et al. CD64 as a biomarker and therapeutic target in HAM/TSP and HTLV-1-associated Infective Dermatitis. Retrovirology 8 (Suppl 1), A95 (2011). https://doi.org/10.1186/1742-4690-8-S1-A95

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  • DOI: https://doi.org/10.1186/1742-4690-8-S1-A95

Keywords

Retrovirology

ISSN: 1742-4690

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