Volume 8 Supplement 1

15th International Conference on Human Retroviruses: HTLV and Related Viruses

Open Access

Proteins function for anti-senescence and monoclonal proliferation of ATL cells

  • Ratiorn Pornkuna1Email author,
  • Shigeki Takemoto1, 2,
  • Koji Uzawa3,
  • Kazuki Morita3 and
  • Fumio Kawano1, 2
Retrovirology20118(Suppl 1):A127

https://doi.org/10.1186/1742-4690-8-S1-A127

Published: 6 June 2011

Background

ATL is a highly aggressive leukemia/lymphoma which was first proposed as a new disease entity in 1977. The long clinical latency and low incidence of ATL indicate that some genetic changes are involved in malignant transformation and monoclonal expansion of HTLV-1-infected cells. Monoclonal proliferation of HTLV-1-infected cells is observed in a part of the virus carriers, who are considered to be the high risk group for development of ATL [1].

We reviewed the process of senescence and how proteins allow the monoclonal proliferation of ATL cells.

Results

Constitutive activation of STAT as well as functional impairment and stabilization of p53 protein found in the PBMCs of ATL patients are supposed to be one base for ATL development [2, 3]. In addition to deletion and/or methylation of the p16INK4A gene, they suggest the inhibition of senescence in ATL cells.

Furthermore, the soluble form of CD30 (sCD30) is elevated in serum of ATL patients and correlates with the aggressiveness of ATL [4] (Our observation) and it is useful marker which indicates the intervention of initiation therapy (Our observation) suggesting that sCD30 allows the proliferation and survival of ATL cells.

Conclusions

Not only the inhibition of senescence by impaired function or constitutive activation of proteins in ATL cells, but also immune regulation by soluble proteins in serum of HTLV-1-infected patients must be required for the progression of ATL.

Authors’ Affiliations

(1)
Institute for Clinical Research, National Hospital Organization Kumamoto Medical Center
(2)
Department of Hematology, National Hospital Organization Kumamoto Medical Center
(3)
Research Laboratories, KYOWA MEDEX CO., LTD.

References

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Copyright

© Pornkuna et al; licensee BioMed Central Ltd. 2011

This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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