- Poster presentation
- Open Access
NRTIs (ZDV and d4T) side effects in PLHAs attending the antiretroviral treatment centre of B. J. Medical College Aad Civil Hospital At Ahmedabad, Gujarat, India
© Nihalani et al; licensee BioMed Central Ltd. 2010
- Published: 11 May 2010
- Peripheral Neuropathy
- Common Side Effect
This study reviews common side effects experienced by PLHAs who were initiated with Zidovudine or Stavudine based FDC ART regimen as per Indian National ART Guidelines attending ART Centre of B. J. Medical College and Civil Hospital, Ahmedabad, Gujarat, India.
All the ICTC confirmed HIV Positive Patients were registered and initiated with FDC ART at ART Center of the Institute as per Indian National ART Guidelines; recommends the use of 2 NRTIs (ZDV/d4T + 3TC) + 1 NNRTI (EFV/NVP). Baseline parameters like CD4 count, necessary laboratory investigations, TB Workup and adherence counseling were carried out and on follow up. Depending on the level of hemoglobin NRTIs were chosen.
No. of Patients
n = 1538
n = 1817
Few patients 15 (0.83%) had multiple side effects, while in remaining 71 (3.91%) the exact reason for regimen change was not available.
The most observed side effects after initiating ART; Anemia (ZDV based) and Peripheral Neuropathy (d4T based) requires regular monitoring for early diagnosis. Substitution within same group must be done. While ART is becoming increasingly effective; side effects are low compared to studies in India and Cambodia by Sharma et. al., 2008 (Anemia 20.0%, Peripheral Neuropathy 22.2%) and Isaakidis et.al., 2008 (Anemia 21.92%). To optimize adherence and hence efficacy, clinicians must focus on preventing side effects whenever possible to yield the overall successfulness to the National Program.
This article is published under license to BioMed Central Ltd.