Modulation of HIV-1-host interaction: role of the Vpu accessory protein

Retrovirology

Table 1 Anti-Tetherin mechanisms reported for the known Tetherin antagonists

Tetherin antagonists	Binding	Mechanisms	References
HIV-1 Vpu	Yes	Proteosomal degradation	[134, 138, 139]
		Lysosomal degradation	[128, 130]
		Sequestration in TGN and/or endosomes	[131, 145]
HIV-2 Env	Yes	Intracellular sequestration	[145, 148]
SIV Nef	?	Increased internalization from the cell-surface?	[150–152]
SIVtan Env	?	Intracellular sequestration	[149]
KSHV K5	?	Lysosomal degradation	[99, 144]
Ebola gp	Yes	?	[98, 147]

ISSN: 1742-4690