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Volume 6 Supplement 3

AIDS Vaccine 2009

P04-35. Neutralisation activity in a geographically diverse East London cohort of HIV-1 infected patients

Background

East London has a diverse population profile, where many of the inhabitants come from abroad. Consequently, they harbour viruses from the farthest corners of the globe, which partly reflect the worldwide HIV-1 epidemic. We have looked at antibody responses in this cohort and tried to establish the relationship of neutralising antibodies to viruses from the same versus different clades.

Methods

To date, >330 patients have been recruited. Neutralisation activity in plasma extracted from the treatment-naive patients was determined on TzmBl cells with a panel of 11 viruses, representing 6 different clades.

Results

Overall, the plasmas do not differ much between the groups in terms of virus neutralisation. However, we did find that clade C infected individuals neutralised the tested clade C viruses significantly better than the clade B patients. Moreover, following titrations clade C plasmas neutralised a CRF02_AG virus better than the AG samples.

Conclusion

Neutralisation activities appeared relatively sporadic and independent of genetic clades, although we suggest that clade C exposure may induce a neutralising humoral response to help control clade C and CRF02_AG challenge.

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Correspondence to H Dreja.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Dreja, H., O'Sullivan, E., Pade, C. et al. P04-35. Neutralisation activity in a geographically diverse East London cohort of HIV-1 infected patients. Retrovirology 6, P63 (2009). https://doi.org/10.1186/1742-4690-6-S3-P63

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Keywords

  • Infectious Disease
  • Cancer Research
  • Antibody Response
  • Infected Patient
  • Infected Individual