Volume 6 Supplement 3

AIDS Vaccine 2009

Open Access

P04-35. Neutralisation activity in a geographically diverse East London cohort of HIV-1 infected patients

  • H Dreja1,
  • E O'Sullivan1,
  • C Pade1,
  • K Aubin1,
  • A Isaksen2,
  • C D'Souza2,
  • J Hand2,
  • C Orkin2,
  • W Leber3,
  • J Anderson3 and
  • Á McKnight1
Retrovirology20096(Suppl 3):P63


Published: 22 October 2009


East London has a diverse population profile, where many of the inhabitants come from abroad. Consequently, they harbour viruses from the farthest corners of the globe, which partly reflect the worldwide HIV-1 epidemic. We have looked at antibody responses in this cohort and tried to establish the relationship of neutralising antibodies to viruses from the same versus different clades.


To date, >330 patients have been recruited. Neutralisation activity in plasma extracted from the treatment-naive patients was determined on TzmBl cells with a panel of 11 viruses, representing 6 different clades.


Overall, the plasmas do not differ much between the groups in terms of virus neutralisation. However, we did find that clade C infected individuals neutralised the tested clade C viruses significantly better than the clade B patients. Moreover, following titrations clade C plasmas neutralised a CRF02_AG virus better than the AG samples.


Neutralisation activities appeared relatively sporadic and independent of genetic clades, although we suggest that clade C exposure may induce a neutralising humoral response to help control clade C and CRF02_AG challenge.

Authors’ Affiliations

Centre of Infectious Diseases, Barts and The London, Queen Mary's School of Medicine and Dentistry
Grahame Hayton Unit, The Royal London Hospital
Homerton University Hospital


© Dreja et al; licensee BioMed Central Ltd. 2009

This article is published under license to BioMed Central Ltd.