Background
Autologous neutralizing antibody responses against HIV-1 have been shown to emerge a number of months after primary infection. It is not known why neutralizing antibodies against HIV-1 are relatively slow to appear. We use the SIV/rhesus macaque model to characterize the kinetics of autologous neutralizing antibody responses and envelope sequence evolution in 4 rhesus monkeys infected intrarectally with SIVmac251.