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Volume 6 Supplement 3

AIDS Vaccine 2009

P15-09. The potential global market size and public health value of hypothetical HIV-1 preventive vaccines with different levels of efficacy

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Background

This study evaluated the potential global market size and value of a hypothetical preventive HIV-1 vaccine that takes into account clade specificity, partial prevention of infection, impact on transmission, delay to treatment, and healthcare system differences regarding HIV-1 screening and its impact on potential market size.

Methods

The potential market size and value of a hypothetical HIV-1 vaccine effective against HIV-1 clades A, B and C was assessed across five different potential product profiles using an Excel-based spreadsheet model. Vaccine efficacy (prevention of acquisition and/or decrease in virus load), disease burden, clade distribution, vaccine price, market segment, vaccine delivery infrastructure, and HIV screening capabilities were taken into account. It was assumed that high disease burden countries (HDBC) where HIV prevalence rates are >1% would routinely vaccinate adolescents, whereas low disease burden countries (LDBC) with HIV prevalence rates < 1% would routinely vaccinate high-risk groups only. Routine vaccination and one-time catch-up campaigns were assessed.

Results

Potential demand and market value was seen across all product profiles and increased with disease impact (e.g., decrease on HIV-1 transmission and delay in time to treatment) and increased efficacy (0% – 60%). The overall potential demand during the routine and catch-up campaign vaccination period was estimated to be 130–270 million peak annual doses in HDBC and 20–60 million peak annual doses in LDBC. The potential value was related to the product profile but was greater than $200 million annually, even for a vaccine expected to modestly decrease transmission and delay treatment by 1–2 years.

Conclusion

This study evaluated in detail the value of a multi-clade HIV-1 vaccine taking into account vaccine, disease, and healthcare complexities. The findings of this study provide donors and suppliers new data to consider in their continuing efforts to develop an HIV-1 vaccine that addresses clades relevant to worldwide disease burden.

Author information

Correspondence to CA Marzetta.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Marzetta, C., Wrobel, S., Singh, K. et al. P15-09. The potential global market size and public health value of hypothetical HIV-1 preventive vaccines with different levels of efficacy. Retrovirology 6, P210 (2009) doi:10.1186/1742-4690-6-S3-P210

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Keywords

  • Market Size
  • Product Profile
  • Campaign Vaccination
  • Potential Demand
  • Vaccination Period