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Volume 6 Supplement 3

AIDS Vaccine 2009

P15-01. Willingness to participate in actual preventive HIV vaccine phase I/IIa trial in Bangkok, Thailand

Background

Willingness to participate (WTP) in prophylactic HIV vaccine trials have been investigated amongst individuals at high risk for HIV and not in the actual HIV vaccine trial itself. We assessed the willingness and barriers to participation in an actual preventive HIV vaccine trial.

Methods

General population in Bangkok inquired about the HIV vaccine trial. Several questionnaires on HIV vaccine trial knowledge were completed during the recruitment process of phase I/IIa trial of DNA/Fowlpox vaccine. Self administered questionnaires on sexual HIV risk behavior, reasons and concerns to participate were completed at the end of the trial by participants and non-participants.

Results

From 131 participants who inquired, the median age was 34 years (IQR: 27 – 46), 73% were male and 30% had at least a bachelor's degree and 11% were screened for the trial. Only 34% completed HIV vaccine knowledge questionnaires, the median score was not significantly different between those who came to screen and those who did not (median score was 7 (IQR 6 – 8) and 6 (IQR 5 – 8) respectively; p = 0.44). Baseline characteristics and method to recruit participants were not different between two groups. Of the 43% who completed self-administered questionnaires, those who were, male gender were more willing (p = 0.038; OR = 6.29, 95% CI = 0.75–52.68) by univariate analysis. Age and education were not associated with WTP. Knowing someone infected with HIV significantly decreased WTP (p = 0.04; OR = 0.23, 95% CI = 0.05–1.01). The most common reasons volunteers declined to participate were concerns that their family would not want them to join and being not sure about the safety of the vaccine.

Conclusion

The low rate of actual WTP is common to HIV vaccine trials. Community education on the importance and safety of the vaccine is needed.

Author information

Correspondence to A Hemachandra.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Hemachandra, A., Puls, R., Kerr, S. et al. P15-01. Willingness to participate in actual preventive HIV vaccine phase I/IIa trial in Bangkok, Thailand. Retrovirology 6, P202 (2009). https://doi.org/10.1186/1742-4690-6-S3-P202

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Keywords

  • Risk Behavior
  • Median Score
  • Knowledge Questionnaire
  • Vaccine Knowledge
  • Reason Volunteer