Background
Development of mucosal adjuvants to elicit immunity in the female genital tract may have important implications for the development of vaccines to counter sexually transmitted infections. We have recently documented the vaginal adjuvant effect of the TLR9 agonist CpG-ODN, and a non-TLR targeting molecule α galactosylceramide (α-GalCer), an invariant natural killer T cell ligand, for induction of protective immunity in the murine female genital tract.