Background
In acute HIV-1 infection (AHI) there are infection-induced polyclonal shifts in blood and bone marrow B-cell subsets from naïve to memory cells and plasmablasts/plasma cells (PCs) coupled with decreased numbers of naive B cells. To study the initial antibody response to HIV, we have used recombinant technology to create a database of PC antibody sequences derived from 3 early stage AHI subjects.