Background
ANRS HIV-LIPO-5 vaccine includes 5 long peptides, Gag17–35, 253–284, Pol325–355, Nef66–97 and 116–145, containing multiple CD8+ and CD4+ T-cell epitopes, coupled to a palmytoil tail. Phase 1 studies have shown that vaccine dosage at 500 μg/lipopeptide elicits cellular immune responses. Whether HIV-LIPO5 immunogenicity varies with the dosage is unknown.