Effectiveness of a early initiation of protease inhibitor-sparing antiretroviral regimen in human immunodeficiency virus-1 vertically infected infants
© Van der Linden et al.; licensee BioMed Central Ltd. 2008
Published: 9 April 2008
Vertically HIV-1-infected infants are at high risk of severe manifestations of the disease in the first year of life . For this reason, we have elected, since 1996, to treat all infants born to HIV-1-infected mothers with a combination of 3 reverse transcriptase inhibitors as soon as the diagnosis of vertical transmission is established.
Material and methods
This is a cohort study of the effectiveness and tolerance of therapy in the 17 HIV-1-infected infants followed from birth in 3 belgian paediatric reference centres since 1996. All of them had been treated according to these guidelines.
Early initiation of treatment with 3 reverse transcriptase inhibitors appeared to be highly effective in this cohort of vertically HIV-1 infected infants. Parental adherence is crucial to the effectiveness of therapy.
The authors would like to thank the patients and their families for their collaboration. This study was funded by the Smiles Foundation, Belgium and Dr Van der Linden received a grant from the European AIDS Clinical Society.
This article is published under license to BioMed Central Ltd.