Volume 5 Supplement 1

Fourth Dominique International Conference. Maternal chronic viral infections transmitted to infants: from mechanisms to prevention and care

Open Access

High prevalence of cytomegalovirus (CMV) infection in infants born to HIV infected mothers–ANRS French Perinatal Cohort (EPF)

  • Gaelle Guibert1,
  • Marianne Leruez-Ville2, 3,
  • Christine Rouzioux2, 3,
  • Roland Tubiana4, 5,
  • Laurent Mandelbrot1, 6, 7,
  • Stéphane Blanche3, 8,
  • Jean-Paul Teglas1, 9,
  • Yassine BenMebarek1, 10,
  • Jérôme Le Chenadec1, 9,
  • Josiane Warszawski1, 9, 10, 11 and
  • ANRS French Perinatal Cohort (EPF)
Retrovirology20085(Suppl 1):O10

https://doi.org/10.1186/1742-4690-5-S1-O10

Published: 9 April 2008

Background

In developed countries, 0.3% to 0.5% of all newborns are congenitally infected by cytomegalovirus (CMV) with the risk of sensorineural hearing loss or mental retardation [1, 2]. Few results about congenital CMV infection in infants born to HIV-infected women have been reported [3]. Rate of disease progression and central nervous system disease was found to be higher in HIV-1-infected infants who acquire CMV infection in the first 18 months of life than those infected with HIV-1 alone [4]. We aimed to estimate the prevalence of neonatal CMV infection in children born to HIV-infected mothers between 1993 and 2004 enrolled in the ANRS French Perinatal Cohort (EPF).

Materials and methods

EPF is a national prospective multicenter cohort of mother-to-child HIV transmission. As part of the standardized follow-up of infants born alive between 1993 and 2004 in EPF sites, a urine sample was obtained within the ten first days of life. These samples were used to screen for congenital CMV infection, using rapid culture from 1993 to 2001 and real-time PCR since 2001.

Results

Between 1993 and 2004, 4995 of the 7878 newborns included in EPF were screened for CMV. The prevalence of CMV infection was 2.4% (119 positive tests; 95% confidence interval: 2.0–2.8). Thirteen of the 119 CMV infected newborns were also infected with HIV. The prevalence of CMV infection was higher in HIV-infected newborns (10.2%; 95% CI: 4.9-15.5) than in HIV-uninfected newborns (2.2%, 95% CI: 1.8-2.6, p<0.01).

Conclusions

The prevalence of congenital CMV infection was high in children born to HIV- infected mothers and was significantly higher in HIV-infected children than HIV-uninfected children.

Declarations

Acknowledgements

The study was supported by the ANRS. We thank all cohort investigators and V Benhammou, N Chernai, A Diop, K Hamrene, P Huynh, C Laurent, M Peres, ERamos, L Boufassa, T Wack, N Zeller.

Authors’ Affiliations

(1)
Inserm, U822, Le Kremlin-Bicêtre
(2)
AP-HP, Virology Department, Necker Hospital
(3)
EA 3620, Univ Paris Descartes 5
(4)
AP-HP, Department of infectious diseases, Hôpital Pitié Salpêtrière
(5)
INSERM, U543
(6)
Univ Paris 7
(7)
AP-HP, Gynecology and obstetrics department, Hôpital Louis Mourrier
(8)
AP-HP, Unité d'Immunologie Hématologie Pédiatrique, Necker Hospital
(9)
INED
(10)
AP-HP, Epidemiology department, Hopital Bicêtre
(11)
Univ Paris-Sud, Faculté de Médecine Paris-Sud

References

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Copyright

© Guibert et al.; licensee BioMed Central Ltd. 2008

This article is published under license to BioMed Central Ltd.

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