Figure 9

Model of Sam68ΔC inhibition of HIV-1 protein expression. The distinct processing pathways of fully spliced versus incompletely spliced viral RNAs result in differences in the composition of the RNPs that appear in the cytoplasm. Upon export, the RNPs undergo compositional changes including the exchange of PABP2 for PABP1 to become translationally active. Sam68ΔC interacts with unique components of the Crm1 exported RNPs to block the exchange of PABP2 for PABP1 or removes PABP1 from the affected RNA, resulting in a block to translation.