- Open Access
APOBEC3G encapsidation into HIV-1 virions: which RNA is it?
© Strebel and Khan; licensee BioMed Central Ltd. 2008
- Received: 11 June 2008
- Accepted: 02 July 2008
- Published: 02 July 2008
APOBEC3G is a cytidine deaminase with potent antiviral activity. The protein deaminates single-stranded DNA but is known to bind cellular and viral RNAs. There is increasing evidence that RNA binding of APOBEC3G is important for packaging into viral particles. However, there is no consensus yet on the type of RNA involved.
- Antiviral Activity
- Cytidine Deaminase
- Viral Core
- Experimental Model System
- Packaging Process
KS is supported by a Grant from the NIH Intramural AIDS Targeted Antiviral Program and by the Intramural Research Program of the NIH, NIAID.
- Sheehy AM, Gaddis NC, Choi JD, Malim MH: Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein. Nature. 2002, 418: 646-650. 10.1038/nature00939.View ArticlePubMedGoogle Scholar
- Goila-Gaur R, Strebel K: HIV-1 Vif, APOBEC, and Intrinsic Immunity. Retrovirology. 2008, 5: 51-10.1186/1742-4690-5-51.PubMed CentralView ArticlePubMedGoogle Scholar
- Bach D, Peddi S, Mangeat B, Lakkaraju A, Strub K, Trono D: Characterization of APOBEC3G binding to 7SL RNA. Retrovirology. 2008, 5 (1): 54-10.1186/1742-4690-5-54.PubMed CentralView ArticlePubMedGoogle Scholar
- Wang T, Tian C, Zhang W, Luo K, Sarkis PT, Yu L, Liu B, Yu Y, Yu XF: 7SL RNA mediates virion packaging of the antiviral cytidine deaminase APOBEC3G. J Virol. 2007, 81: 13112-13124. 10.1128/JVI.00892-07.PubMed CentralView ArticlePubMedGoogle Scholar
- Onafuwa-Nuga AA, Telesnitsky A, King SR: 7SL RNA, but not the 54-kd signal recognition particle protein, is an abundant component of both infectious HIV-1 and minimal virus-like particles. RNA. 2006, 12: 542-546. 10.1261/rna.2306306.PubMed CentralView ArticlePubMedGoogle Scholar
- Khan MA, Goila-Gaur R, Opi S, Miyagi E, Takeuchi H, Kao S, Strebel K: Analysis of the contribution of cellular and viral RNA to the packaging of APOBEC3G into HIV-1 virions. Retrovirology. 2007, 4: 48-10.1186/1742-4690-4-48.PubMed CentralView ArticlePubMedGoogle Scholar
- Svarovskaia ES, Xu H, Mbisa JL, Barr R, Gorelick RJ, Ono A, Freed EO, Hu WS, Pathak VK: Human apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3G (APOBEC3G) is incorporated into HIV-1 virions through interactions with viral and nonviral RNAs. J Biol Chem. 2004, 279: 35822-35828. 10.1074/jbc.M405761200.View ArticlePubMedGoogle Scholar
- Goila-Gaur R, Khan MA, Miyagi E, Kao S, Strebel K: Targeting APOBEC3A to the viral nucleoprotein complex confers antiviral activity. Retrovirology. 2007, 4: 61-10.1186/1742-4690-4-61.PubMed CentralView ArticlePubMedGoogle Scholar
- Aguiar RS, Lovsin N, Tanuri A, Peterlin BM: Vpr.A3A Chimera Inhibits HIV Replication. J Biol Chem. 2008, 283: 2518-2525. 10.1074/jbc.M706436200.View ArticlePubMedGoogle Scholar
- Khan MA, Kao S, Miyagi E, Takeuchi H, Goila-Gaur R, Opi S, Gipson CL, Parslow TG, Ly H, Strebel K: Viral RNA is required for the association of APOBEC3G with human immunodeficiency virus type 1 nucleoprotein complexes. J Virol. 2005, 79: 5870-5874. 10.1128/JVI.79.9.5870-5874.2005.PubMed CentralView ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.