- Poster presentation
- Open Access
HIV-1 natural viral suppressors: control of viral replication in the absence of therapy
- Mohammad Sajadi1
© Sajadi; licensee BioMed Central Ltd. 2006
- Published: 21 December 2006
- Viral Load
- Proviral Load
- Viral Load Measurement
- Immunoregulatory Mechanism
- Proviral Copy
HIV Natural Viral Suppressors (NVS) are individuals with HIV-1 that are able to suppress HIV viral replication to undetectable levels in the absence of antiretroviral therapy. By contrast, Long-Term Nonprogressors (LTNP), represent individuals who are HIV-1 infected but who maintain high CD4 counts over many years (no where in the definition of LTNPs is viral load considered, and in most series the HIV-1 viral loads range from 102 to 104 copies/ml) [1–3]. We present here a cohort of NVS, providing a case definition for identifying such individuals and the results of preliminary evaluations.
Confirmed HIV-1 by Western blot.
Positive HIV-1 Proviral DNA.
Viral loads <400 copies/ml at all time points for at least a 2 year period and 4 viral load measurements (One viral blip or viral load > 400 copies/ml during the above time period was permitted if the subsequent viral loads were <400).
No more than 2 weeks of antiretroviral (ART) use (unless administered for pregnancy prophylaxis)
Studies included High Input PCR for Proviral DNA copy number.
35 patients were identified as NVS, and 22 have been enrolled. Demographics are shown in Table 1.
Demographics of the NVS cohort
51 (range 38–60)
Male 64%, Female 36%
African American 100%
Median years with HIV
12 (range 2–19)
Median years viral suppression
5 (range 2–9)
Median of latest CD4 count (cells/ul)
887 (range 346–1564)
Average number of viral loads tested
13 (range 4–21)
Patients with HIV-1 infection who are able to naturally suppress HIV infection in the absence of therapy represent one particular extreme of HIV infected patients. Although it is too early to postulate on the factor or factors that makes this group unique, there are likely multiple mechanisms involved in effective in vivo regulation of HIV resulting in persistent non-therapeutic induced viral suppression. The study of NVS, which represent a more homologous group than LTNP in regards to HIV-1 suppression, should lead to better understanding of the immunoregulatory mechanisms involved. Studies are underway to determine and further characterize the in vivo mechanisms responsible for control of HIV-1 replication seen in Natural Viral Suppressors.
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This article is published under license to BioMed Central Ltd.