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Adult T-cell leukemia/lymphoma in a Caucasian patient after sexual transmission of HTLV-1

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Retrovirology201512 (Suppl 1) :P76

https://doi.org/10.1186/1742-4690-12-S1-P76

  • Published:

Keywords

  • Breast Milk
  • Sexual Intercourse
  • Intravenous Drug
  • Molecular Subtype
  • Caucasian Patient

Adult T-cell leukemia/lymphoma (ATLL) is an aggressive T-cell lymphoproliferation caused by human T-cell lymphotropic virus type-1 (HTLV-1). This oncogenic human retrovirus can be acquired by mother-to-child transmission through prolonged breast-feeding, sexual transmission, or from transfused infected blood cells or intravenous drug abuse. HTLV-1 infects approximately 5–10 million individuals worldwide and, among them, 1–5% will develop ATLL during their lifetime. Four major geographic molecular subtypes (genotypes) have been reported including the cosmopolitan a-subtype, the Central African b-subtype, the Central African/Pygmies d-subtype and the Australo-Melanesian c-subtype. The results of several studies showed that most cases of ATLL develop in individuals who have been infected with HTLV-1 as young children via their mothers’ breast milk. The very rare ATLL cases observed following transfusion or sexual transmission are still being debated. Here, we report on a Caucasian French patient, with HTLV-1–seronegative parents, who developed ATLL, characterized by a clonal T cell skin proliferation of CD4+ and CD25+ cells, 18 years after highly probable sexual transmission of HTLV-1 through repeated unprotected sexual intercourse with a Cameroonian woman. Indeed, genotyping of the patient's virus revealed infection with an HTLV-1 b-subtype strain, typically of Central African origin, especially Cameroon. This case definitively confirms the hypothesis that ATLL can develop, albeit rarely, after infection during adulthood, outside breast-feeding.

Authors’ Affiliations

(1)
Hématologie Adulte, Hôpital Universitaire Necker–Enfants Malades, Assistance Publique– Hôpitaux de Paris (APHP), Paris, France
(2)
INSERM U1163 and CNRS ERL 8254 Bases Cellulaires et Moléculaires des Désordres Hématologiques, France
(3)
Institut Imagine, Université Paris Descartes– Sorbonne Paris Cité, Paris, France
(4)
Institut Pasteur, Unité d'Epidémiologie et Physiopathologie des Virus Oncogènes, Département de Virologie, Paris, France
(5)
CNRS, UMR 3569, Rue du Docteur Roux, F-75015 Paris, France
(6)
Département de Pathologie, Hôpital Purpan, Toulouse, France
(7)
Laboratoire d'Hématologie, Hôpital Universitaire Necker–Enfants Malades, Assistance Publique–Hôpitaux de Paris (APHP), Paris, France
(8)
Hématologie, Institut Gustave-Roussy, Villejuif, France
(9)
Laboratoire de Virologie, Hôpital Purpan, Toulouse, France
(10)
Département de Dermatologie, Hôpital Ambroise-Paré, Boulogne-Billancourt, France
(11)
Laboratoire d'Oncovirologie et Biothérapies, CNRS UMR 5239, Centre Hospitalier Lyon Sud, Lyon, France
(12)
Department of Internal Medicine, American University of Beirut, Beirut, Lebanon

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