Volume 12 Supplement 1

17th International Confernce on Human Retroviruses: HTLV and Related Viruses

Open Access

Absence of association of IFNL3/IL28B rs 12979860 and IFNL4 ss 469415590 polymorphisms with the neurological status of HTLV-1 Afro-Caribbean subjects in Martinique.

  • Severine Jeannin1,
  • Jean-Marc Costa4,
  • Jean-Dominique Poveda4,
  • Gilda Belrose2,
  • Agnes Lezin2,
  • Andre Cabie3,
  • Raymond Cesaire2 and
  • Stephane Olindo1
Retrovirology201512(Suppl 1):P61

https://doi.org/10.1186/1742-4690-12-S1-P61

Published: 28 August 2015

Background

The polymorphism of Interferon-lambda3/Interleukine28B (IFNL3/IL28B) rs 12979860 has been described as important in the development of HTLV-1-associated myelopathy/spastic paraparesis (HAM/TSP). Recently, the dinucleotide polymorphism, IFNL4 ss469415590 has been discovered and is in high linkage disequilibrium with rs12979860. In a transversal study, we aimed to examine the polymorphisms of these two nucleotides in our HTLV-1 Afro-Caribbean population.

Methods

The frequencies of the CC, CT and TT genotypes of the single nucleotide rs12979860 and the frequencies of ΔG/ΔG, ΔG/TT and TT/TT genotypes of the dinucleotide ss469415590 are reported in the entire HTLV-1 group and compared between asymptomatic individuals and HAM/TSP patients.

Results

In our 94 HTLV-1 subjects, frequencies of rs1299860 were CC, 13.3%; CT, 44.7%; TT, 42% and frequencies of ss469415590 genotypes were ΔG/ΔG, 45.7%; ΔG/TT, 42.6%; TT/TT, 11.7%. We found no significant difference in allele distribution in both studied nucleotide polymorphism between 53 asymptomatic carriers (60.7 years and 72% females) and 41 HAM/TSP patients (70 years and 80% females).

Conclusion

In our population, the polymorphisms of IFNL3/IL28B rs12979860 and IFNL4 ss469415590 are not associated with HTLV-1 neurological phenotype status. Different genotypes target should be considered.

Authors’ Affiliations

(1)
Service de Neurologie, Centre Hospitalier Universitaire de Martinique
(2)
Service de Viro-Immunologie, Centre Hospitalier Universitaire de Martinique
(3)
Service des maladies Infectieuses, Centre Hospitalier Universitaire de Martinique
(4)
Pasteur-CERBA, Cergy-Pontoise

Copyright

© Jeannin et al. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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