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  • Oral presentation
  • Open Access

HTLV-1 infection modulates the immune response in HIV-HCV coinfected patients and may increase spontaneous HCV clearance

  • 1,
  • 1,
  • 1,
  • 2 and
  • 1
Retrovirology201411 (Suppl 1) :O8

https://doi.org/10.1186/1742-4690-11-S1-O8

  • Published:

Keywords

  • Immune Response
  • Infectious Disease
  • Cancer Research
  • Plasma Level
  • Detectable Level

Background

HTLV-1 often infect HIV-HCV coinfected patients. The immunological consequences of triple infection are still unclear. Objective: to compare the plasma levels of 25 different cytokines in patients infected by HIV and HCV, according to their serological status to HTLV-1 infection.

Methods

We used the LUMINEX 100/200 analyzer to compare the plasma levels of 25 different cytokines for patients coinfected by HCV and HIV (N=15), or by HTLV-1, HCV and HIV(N=18, 3 of them spontaneously cleared HCV).

Results

We detected a significant increase in median plasma levels of 6 different cytokines (Table 1) for patients coinfected by HTLV-1.Only the 3 patients with HCV spontaneous clearance showed detectable levels of IL-15 (p=0.06). Levels of remaining 18 cytokines were similar for all groups.

Table 1

 

Median Plasma levels of cytokines, according to type of infection

 

Cytokines

HIV+ HTLV (spontaneous clearance of HCV)

HIV+ HTLV+HCV

HIV+HCV

P value

 

N = 3

N = 14

N = 15

 

IL-1b

88,7

16,6

1,1

0,01

IL-2

280,4

72,7

15,1

0,01

FGF

57,8

26,3

14,3

0,03

IFN-g

1580,7

571,4

224,7

0,04

IP-10

70896,1

46985,6

3753,9

0,03

MIP-1a

15862,6

103,0

20,5

0,00

MIP-1b

14301,3

4732,3

666,5

0,01

TNF-a

1144,8

155,7

33,7

0,01

Conclusions

Infection by HTLV-1, in HIV-HCV coinfected patients, seems to induce a greater release of pro-inflamatory cytokines. This can be associated with a higher rate of HCV spontaneous clearance.

Authors’ Affiliations

(1)
Laboratório de Pesquisa em Infectologia, Complexo Hospitalar Prof. Edgard Santos – Federal University of Bahia, Brazil
(2)
FIOCRUZ, Rio de Janeiro, Brazil

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