Volume 11 Supplement 1

16th International Conference on Human Retroviruses: HTLV and Related Viruses

Open Access

HTLV-1 infection modulates the immune response in HIV-HCV coinfected patients and may increase spontaneous HCV clearance

  • Fabianna Bahia1,
  • Marcos H Abrahão1,
  • Eduardo M Netto1,
  • Patricia Bozza2 and
  • Carlos Brites1
Retrovirology201411(Suppl 1):O8

https://doi.org/10.1186/1742-4690-11-S1-O8

Published: 7 January 2014

Background

HTLV-1 often infect HIV-HCV coinfected patients. The immunological consequences of triple infection are still unclear. Objective: to compare the plasma levels of 25 different cytokines in patients infected by HIV and HCV, according to their serological status to HTLV-1 infection.

Methods

We used the LUMINEX 100/200 analyzer to compare the plasma levels of 25 different cytokines for patients coinfected by HCV and HIV (N=15), or by HTLV-1, HCV and HIV(N=18, 3 of them spontaneously cleared HCV).

Results

We detected a significant increase in median plasma levels of 6 different cytokines (Table 1) for patients coinfected by HTLV-1.Only the 3 patients with HCV spontaneous clearance showed detectable levels of IL-15 (p=0.06). Levels of remaining 18 cytokines were similar for all groups.

Table 1

 

Median Plasma levels of cytokines, according to type of infection

 

Cytokines

HIV+ HTLV (spontaneous clearance of HCV)

HIV+ HTLV+HCV

HIV+HCV

P value

 

N = 3

N = 14

N = 15

 

IL-1b

88,7

16,6

1,1

0,01

IL-2

280,4

72,7

15,1

0,01

FGF

57,8

26,3

14,3

0,03

IFN-g

1580,7

571,4

224,7

0,04

IP-10

70896,1

46985,6

3753,9

0,03

MIP-1a

15862,6

103,0

20,5

0,00

MIP-1b

14301,3

4732,3

666,5

0,01

TNF-a

1144,8

155,7

33,7

0,01

Conclusions

Infection by HTLV-1, in HIV-HCV coinfected patients, seems to induce a greater release of pro-inflamatory cytokines. This can be associated with a higher rate of HCV spontaneous clearance.

Authors’ Affiliations

(1)
Laboratório de Pesquisa em Infectologia, Complexo Hospitalar Prof. Edgard Santos – Federal University of Bahia
(2)
FIOCRUZ

Copyright

© Bahia et al; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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