HTLV-1 infection modulates the immune response in HIV-HCV coinfected patients and may increase spontaneous HCV clearance
© Bahia et al; licensee BioMed Central Ltd. 2014
Published: 7 January 2014
HTLV-1 often infect HIV-HCV coinfected patients. The immunological consequences of triple infection are still unclear. Objective: to compare the plasma levels of 25 different cytokines in patients infected by HIV and HCV, according to their serological status to HTLV-1 infection.
We used the LUMINEX 100/200 analyzer to compare the plasma levels of 25 different cytokines for patients coinfected by HCV and HIV (N=15), or by HTLV-1, HCV and HIV(N=18, 3 of them spontaneously cleared HCV).
Median Plasma levels of cytokines, according to type of infection
HIV+ HTLV (spontaneous clearance of HCV)
N = 3
N = 14
N = 15
Infection by HTLV-1, in HIV-HCV coinfected patients, seems to induce a greater release of pro-inflamatory cytokines. This can be associated with a higher rate of HCV spontaneous clearance.
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